Role of SOX2 O-GIcNAcylation in pluripotency

SOX2 O-GlcNAcNA 酰化在多能性中的作用

基本信息

项目摘要

 DESCRIPTION (provided by applicant): Transcription factors are central for establishing the cell type-specific gene expression patterns that characterize each of the hundreds of different cell types in developing and adult mammals. Transcription factors are often regulated by signaling pathways, which affect the activity of these factors and ensure appropriate transcriptional responses to developmental and environmental cues. Our preliminary studies indicate that a transcription factor central to embryonic stem cell self-renewal, SOX2, is modified by addition of an O-linked N-acetylglucosamine sugar to serine residue 248 and threonine residue 213. This modification is mediated by the enzyme OGT, which is a central player in the nutrient sensing pathway that detects levels of glucose and other nutrients. We propose to investigate the role of this post-translational modification of SOX2 in self-renewal, to better understand how metabolic pathways impact gene expression in pluripotent cells.


项目成果

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BARBARA PANNING其他文献

BARBARA PANNING的其他文献

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{{ truncateString('BARBARA PANNING', 18)}}的其他基金

Control of bacterial infections by a horizontally acquired host peptidoglycan amidase
通过水平获得的宿主肽聚糖酰胺酶控制细菌感染
  • 批准号:
    10306384
  • 财政年份:
    2019
  • 资助金额:
    $ 31.3万
  • 项目类别:
Role of SOX2 O-GIcNAcylation in pluripotency
SOX2 O-GlcNAcNA 酰化在多能性中的作用
  • 批准号:
    9060597
  • 财政年份:
    2016
  • 资助金额:
    $ 31.3万
  • 项目类别:
Investigation of X chromosome organization before the onset of X-inactivation
X 失活发生前 X 染色体组织的研究
  • 批准号:
    8650906
  • 财政年份:
    2012
  • 资助金额:
    $ 31.3万
  • 项目类别:
Investigation of X chromosome organization before the onset of X-inactivation
X 失活发生前 X 染色体组织的研究
  • 批准号:
    8387975
  • 财政年份:
    2012
  • 资助金额:
    $ 31.3万
  • 项目类别:
REGULATION OF 3-D CHROMATIN ARCHITECTURE OF EMBRYONIC STEM CELLS
胚胎干细胞 3-D 染色质结构的调控
  • 批准号:
    8362740
  • 财政年份:
    2011
  • 资助金额:
    $ 31.3万
  • 项目类别:
POSTTRANSLATIONAL MODIFICATIONS ON HISTONES AND HISTONE VARIANTS
组蛋白和组蛋白变异体的翻译后修饰
  • 批准号:
    8363763
  • 财政年份:
    2011
  • 资助金额:
    $ 31.3万
  • 项目类别:
Regulation of Xist RNA processing in embryonic stem cells
胚胎干细胞中 Xist RNA 加工的调控
  • 批准号:
    8303428
  • 财政年份:
    2010
  • 资助金额:
    $ 31.3万
  • 项目类别:
Regulation of Xist RNA processing in embryonic stem cells
胚胎干细胞中 Xist RNA 加工的调控
  • 批准号:
    8113864
  • 财政年份:
    2010
  • 资助金额:
    $ 31.3万
  • 项目类别:
POSTTRANSLATIONAL MODIFICATIONS ON HISTONES AND HISTONE VARIANTS
组蛋白和组蛋白变异体的翻译后修饰
  • 批准号:
    8169757
  • 财政年份:
    2010
  • 资助金额:
    $ 31.3万
  • 项目类别:
Regulation of Xist RNA processing in embryonic stem cells
胚胎干细胞中 Xist RNA 加工的调控
  • 批准号:
    8508949
  • 财政年份:
    2010
  • 资助金额:
    $ 31.3万
  • 项目类别:

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