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Neuroplasticity in an Extended Amygdala Network as a Target Mechanism for Attention Bias Modification Outcome

扩展杏仁核网络中的神经可塑性作为注意偏差修改结果的目标机制

基本信息

批准号：
9377234
负责人：
Joshua Carlson
金额：
$ 35.82万
依托单位：
NORTHERN MICHIGAN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-15 至 2021-09-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9377234
关键词：
Academic Research Enhancement Awards Amygdaloid structure Anterior Anxiety Anxiety Disorders Attention Behavior Brain Brain region Data Dendritic Spines Depressed mood Development Disease Effectiveness Environment Family Functional Magnetic Resonance Imaging Funding Funding Agency Grant Human Individual Institution Learning Link Magnetic Resonance Imaging Measures Medial Mental disorders Michigan Modification National Institute of Mental Health Near-Infrared Spectroscopy Negative Valence Neuronal Plasticity Outcome Participant Prefrontal Cortex Privatization Regimen Research Research Project Grants Resources Rural Students Training United States National Institutes of Health Universities Visual Visual Cortex anxiety symptoms anxiety treatment attentional bias attentional control basal forebrain base cingulate cortex clinically relevant cognitive training college comparative efficacy computerized density experience gray matter hands on research morphometry neuroimaging therapy development trait undergraduate student

项目摘要

Abstract Northern Michigan University (NMU) is a rural primarily undergraduate university with approximately 8,000 students located in Michigan's sparsely populated and economically depressed Upper Peninsula. The proposed research will meet the objectives of the AREA grant by providing students with significant hands-on experience in clinically relevant human neuroimaging research and by strengthening the research environment of NMU. Anxiety disorders are one of the most common psychological disorders. Underlying anxiety is an increased attentional bias to threat, which has been identified as a causal contributor in the development of anxiety. Given this causal relationship, attention bias modification was introduced as a treatment option where anxiety is reduced by training individuals to direct their attention away from threat and thereby decreasing anxiety. Over a decade of research using this approach, called attention bias modification (ABM), suggests that overall the approach is effective in reducing anxiety. Although ABM appears to be a very promising treatment option for anxiety, there are several factors limiting the effectiveness of ABM. These include the recognition of individual-level needs and a known underlying mechanism of action by which ABM is effective. Neuroimaging evidence suggests that attentional bias to visual threat is associated with a network of brain regions including the amygdala, anterior cingulate cortex, and visual cortex. In human participants, experience- dependent neuroplasticity is visible in the voxel-based morphometry based measures of gray matter volume following training. Recently, voxel-based morphometry measures of gray matter volume have been linked to dendritic spine density—a known cellular mechanism for learning-related neuroplasticity. Thus, voxel-based morphometry measures are ideally suited to measure learning-related neuroplasticity following attention bias modification. In this proposal participants' level of attentional bias, anxiety, and gray matter volume will be measured before and after completing six weeks of attention bias modification training (N = 50) or attention control training (N= 50). The proposal aims to (1) establish that pre-treatment bias predicts variability in the gray matter volume in the extended amygdala and anterior cingulate cortex, (2) assess the extent to which reduced extended amygdala and anterior cingulate cortex gray matter volume following ABM underlies reductions in attentional bias and anxiety, and (3) Establish pre-treatment bias as a predictor of successful ABM as measured by reduced bias, reduced anxiety, and reduced gray matter volume in the extended amygdala and anterior cingulate cortex. Consistent with the objectives of the AREA grant and NIMH's focus on identifying and validating new targets for treatment development that underlie disease mechanisms, the current proposal plans to involve students at a rural primarily undergraduate university in a research project aimed at establishing neuroplasticity in the extended amygdala and anterior cingulate cortex as a target mechanism for ABM training outcome, which could be used to objectively track training-related outcomes in anxiety treatment.

摘要北方密歇根大学（NMU）是一所以农村为主的本科大学，密歇根州人口稀少，经济萧条的上半岛。的拟议的研究将通过为学生提供重要的动手实践来满足区域补助金的目标临床相关的人类神经影像学研究经验，并通过加强研究环境的NMU。焦虑症是最常见的心理障碍之一。潜在的焦虑是增加对威胁的注意偏向，这已被确定为发展的因果贡献者，焦虑鉴于这种因果关系，注意力偏差修正被引入作为一种治疗选择，通过训练个体将他们的注意力从威胁上转移开，从而减少焦虑，焦虑十多年来，使用这种称为注意力偏差修正（ABM）的方法进行的研究表明，总的来说，这种方法在减少焦虑方面是有效的。虽然反弹道导弹似乎是一个非常有前途的作为焦虑症的治疗选择，有几个因素限制了ABM的有效性。其中包括认识到个人层面的需要和反弹道导弹有效的已知基本作用机制。神经影像学证据表明，对视觉威胁的注意偏向与大脑网络有关，包括杏仁核、前扣带皮层和视觉皮层的区域。在人类参与者中，经验- 依赖性神经可塑性在基于体素的形态测量的灰质体积测量中可见经过培训。最近，灰质体积的基于体素的形态测量已经与树突棘密度-一种已知的学习相关神经可塑性的细胞机制。因此，基于体素形态测量法非常适合测量注意偏向后与学习相关的神经可塑性改性在这个提议中，参与者的注意力偏差，焦虑和灰质体积的水平将被在完成六周的注意力偏差修正训练（N = 50）或注意力对照训练（N= 50）。该提案旨在（1）确定治疗前偏倚预测了在扩展杏仁核和前扣带皮层灰质体积，（2）评估的程度， ABM后扩展杏仁核和前扣带皮质灰质体积减少减少注意力偏差和焦虑，（3）建立治疗前偏差作为成功的预测因子 ABM通过减少偏差、减少焦虑和减少灰质体积来测量，杏仁核和前扣带皮层。与地区赠款的目标和NIMH的重点一致，确定和验证作为疾病机制基础的治疗开发的新靶点，一项提案计划让一所农村大学的学生参与一个研究项目，在扩展杏仁核和前扣带皮层中建立神经可塑性作为 ABM训练结果，可用于客观跟踪焦虑治疗中的训练相关结果。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The questionable validity of attention bias variability: Evidence from two conceptually unrelated cognitive tasks.

DOI：
10.1016/j.jadr.2022.100411
发表时间：
2022-12-01
期刊：
Journal of affective disorders reports
影响因子：
0
作者：
Carlson, Joshua M;Fang, Lin;Kassel, Dahlia
通讯作者：
Kassel, Dahlia

The gray matter morphology associated with the electrophysiological response to errors in individuals with high trait anxiety.

灰质形态与高特质焦虑个体对错误的电生理反应相关。

DOI：
10.1016/j.ijpsycho.2022.12.007
发表时间：
2023
期刊：
International journal of psychophysiology : official journal of the International Organization of Psychophysiology
影响因子：
0
作者：
Fang,Lin;Andrzejewski,JeremyA;Carlson,JoshuaM
通讯作者：
Carlson,JoshuaM

Eye-size effects in the dot-probe task: Greater sclera exposure predicts delayed disengagement from fearful faces.

DOT探针任务中的眼睛尺寸效果：更大的巩膜暴露预测可怕面孔的脱离脱离。