Filling a Void of Research (FAVOR) Training for Transplant Surgeons

填补移植外科医生研究（FAVOR）培训的空白

• 批准号: 9324129
• 负责人: PETER G STOCK
• 金额: $ 31.34万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9324129
• 关键词: Research Training; Transplant Surgeon

PROJECT SUMMARY/ABSTRACT The FAVOR T32 titled “Filling a Void of Research Training for Transplant Surgeons” will prepare surgical residents for translational research careers in abdominal and thoracic transplant surgery. This program will train and inspire a unique cadre of surgeon-scientists to translate astute observations at the bedside, in the operating room, and in the clinic into novel hypotheses that can be interrogated through immunology-focused translational research. This program is uniquely focused, serving a growing need to train the next generation of transplant surgeon-scientists that can contribute to the burgeoning field of translational and personalized medicine. FAVOR is structured to reverse the dismal trend resulting in only 1.8% of ASTS trained surgical fellows successfully competing for NIH-K series awards, despite 76% being motivated to spend more time in research (Englesbe et al., AJT 2010:10, 191-193; Kirk & Feng, AJT 2011, 11; 191-193). The training includes a base curriculum that includes a novel “T32 FAVOR Immersion Workshop,” as well as core courses in Designing Clinical Research, Statistical Computing and Database Management in Clinical Research, Scientific Writing, and Biostatistical Methods for Clinical Research. The FAVOR T32 also includes specialized training electives which will be tailored to each trainee based on long term goals and interests. A small cadre of surgical trainees from within UCSF, all training grant eligible and highly diverse (~40% URM, 50% female), will be selected for FAVOR. We will also invite trainees from other academic institutions by competitive application for a total of 3 training slots/ year, where trainees will dedicate two full-time years, without significant clinical responsibilities, towards research education and training. One trainee slot/year would also be eligible to enroll in a 1-2 year degree course in Clinical/Translational Medicine. Trainees will be prepared to apply their training to deepen understanding of the immune system, as well as developing new, immune-based diagnostics, prognostics, therapeutics and clinical approaches that are relevant to surgical procedures and outcomes. While in the program they will also learn how to develop and draw upon clinical databases that integrate surgical outcomes with data from pathology and immunology. FAVOR's NIH-funded faculty, with distinguished track records in immunology and translational research, have been specially selected to inspire and guide trainees in translational mentored research, with selection of 2 mentors/trainee from each of the clinical and scientific mentor pools. Post-training career advice and guidance will facilitate placement into prestigious fellowships and academic faculty positions for FAVOR trainees. The national impact of the FAVOR program will be realized through the scientific maturation of a trainee group with comprehensive clinical expertise and outstanding translational science, with the ability to apply translational immunology to benefit organ transplant recipients.

项目概要/摘要 题为“填补移植外科医生研究培训的空白”的 FAVOR T32 将为手术做好准备 腹部和胸部移植手术转化研究职业的住院医师。该计划将 培训和激励一支独特的外科医生科学家队伍，将敏锐的观察结果转化为临床实践 在手术室和临床中提出新的假设，这些假设可以通过以免疫学为重点的方法进行质疑 转化研究。该计划的重点是独特的，满足培训下一代的日益增长的需求 移植外科医生科学家可以为新兴的转化和个性化领域做出贡献 药品。 FAVOR 旨在扭转这一令人沮丧的趋势，导致只有 1.8% 的 ASTS 受过外科手术培训 研究员成功角逐 NIH-K 系列奖项，尽管 76% 的研究员有动力花更多时间 研究（Englesbe 等人，AJT 2010:10, 191-193；Kirk & Feng，AJT 2011, 11；191-193）。培训内容包括 基础课程，包括新颖的“T32 FAVOR 沉浸式研讨会”以及核心课程 设计临床研究、临床研究中的统计计算和数据库管理、科学 临床研究的写作和生物统计方法。 FAVOR T32 还包括专门培训 选修课将根据长期目标和兴趣为每位学员量身定制。一个小干部 来自 UCSF 内部的外科受训人员，所有符合培训补助金资格且高度多样化的人员（约 40% URM，50% 女性），将 被选为“FAVOR”。我们还将通过竞争性申请邀请其他学术机构的学员 每年总共 3 个培训名额，受训者将投入两年全职时间，无需进行重大临床培训 责任，进行研究教育和培训。每年一个实习生名额也有资格报名 攻读 1-2 年临床/转化医学学位课程。学员将准备好应用他们的培训 加深对免疫系统的了解，并开发新的基于免疫的诊断方法， 与手术程序和结果相关的预后、治疗和临床方法。尽管 在该计划中，他们还将学习如何开发和利用整合外科手术的临床数据库 病理学和免疫学数据的结果。 FAVOR 的师资队伍由 NIH 资助，成绩斐然 免疫学和转化研究方面的记录经过专门挑选，以激励和指导学员 转化指导研究，从临床和科学领域各选择 2 名导师/实习生 导师库。培训后的职业建议和指导将有助于进入享有盛誉的奖学金 以及 FAVOR 学员的学术教职职位。 FAVOR 计划的全国影响将是 通过具有全面临床专业知识的实习生团队的科学成熟来实现 杰出的转化科学，能够应用转化免疫学造福器官移植 收件人。