Filling a Void of Research (FAVOR) Training for Transplant Surgeons

填补移植外科医生研究（FAVOR）培训的空白

• 批准号: 10474504
• 负责人: PETER G STOCK
• 金额: $ 33.37万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10474504
• 关键词: Research Training; Transplant Surgeon

PROJECT SUMMARY/ABSTRACT The FAVOR T32 titled “Filling a Void of Research Training for Transplant Surgeons” will prepare surgical residents for translational research careers in abdominal and thoracic transplant surgery. This program will train and inspire a unique cadre of surgeon-scientists to translate astute observations at the bedside, in the operating room, and in the clinic into novel hypotheses that can be interrogated through immunology-focused translational research. This program is uniquely focused, serving a growing need to train the next generation of transplant surgeon-scientists that can contribute to the burgeoning field of translational and personalized medicine. FAVOR is structured to reverse the dismal trend resulting in only 1.8% of ASTS trained surgical fellows successfully competing for NIH-K series awards, despite 76% being motivated to spend more time in research (Englesbe et al., AJT 2010:10, 191-193; Kirk & Feng, AJT 2011, 11; 191-193). The training includes core courses in Designing Clinical Research, Statistical Computing and Database Management in Clinical Research, Scientific Writing, and Biostatistical Methods for Clinical Research. The FAVOR T32 also includes specialized training electives, which will be tailored to each trainee based on long-term goals and interests. A small cadre of surgical trainees from within UCSF, all training grant eligible and highly diverse (~40% URM, 50% female), will be selected for FAVOR. We will also invite trainees from other academic institutions by competitive application for training slots, where trainees will dedicate two full-time years, without significant clinical responsibilities, towards research education and training. One trainee slot/year will also be eligible to enroll in a 1-2 year degree course in Clinical/Translational Medicine. Trainees will be prepared to apply their training to deepen understanding of the immune system, as well as developing new, immune-based diagnostics, prognostics, therapeutics and clinical approaches that are relevant to surgical procedures and outcomes. While in the program they will also learn how to develop and draw upon clinical databases that integrate surgical outcomes with data from pathology and immunology. FAVOR's NIH-funded faculty, with distinguished track records in immunology and translational research, have been specially selected to inspire and guide trainees in translational mentored research, with selection of 2 mentors/trainee from each of the clinical and scientific mentor pools. Post-training career advice and guidance will facilitate placement into prestigious fellowships and academic faculty positions for FAVOR trainees. The national impact of the FAVOR program will be realized through the scientific maturation of a trainee group with comprehensive clinical expertise and outstanding translational science, with the ability to apply translational immunology to benefit organ transplant recipients.

项目概要/摘要 题为“填补移植外科医生研究培训的空白”的 FAVOR T32 将为手术做好准备 腹部和胸部移植手术转化研究职业的住院医师。该计划将 培训和激励一支独特的外科医生科学家队伍，将敏锐的观察结果转化为临床实践 在手术室和临床中提出新的假设，这些假设可以通过以免疫学为重点的方法进行质疑 转化研究。该计划的重点是独特的，满足培训下一代的日益增长的需求 移植外科医生科学家可以为新兴的转化和个性化领域做出贡献 药品。 FAVOR 旨在扭转这一令人沮丧的趋势，导致只有 1.8% 的 ASTS 受过外科手术培训 研究员成功角逐 NIH-K 系列奖项，尽管 76% 的研究员有动力花更多时间 研究（Englesbe 等人，AJT 2010:10, 191-193；Kirk & Feng，AJT 2011, 11；191-193）。培训内容包括 临床研究设计、临床统计计算和数据库管理核心课程 临床研究的研究、科学写作和生物统计方法。 FAVOR T32 还包括 专门的培训选修课，将根据长期目标和兴趣为每位学员量身定制。一个 来自 UCSF 内部的一小批外科学员骨干，所有培训补助金均合格且高度多样化（~40% URM， 50% 女性），将被选为“FAVOR”。我们还将邀请其他学术机构的学员 培训名额的竞争性申请，受训者将全职工作两年，无需花费大量时间 临床职责，研究教育和培训。每年一个实习生名额也将有资格获得 报名参加 1-2 年临床/转化医学学位课程。学员将准备好应用他们的 培训以加深对免疫系统的了解，以及开发新的、基于免疫的 与外科手术相关的诊断、预后、治疗和临床方法 结果。在该计划中，他们还将学习如何开发和利用临床数据库 将手术结果与病理学和免疫学数据相结合。 FAVOR 的 NIH 资助教师， 免疫学和转化研究领域的杰出记录被特别挑选来激励 并指导受训者进行转化指导研究，从每个项目中选择 2 名导师/受训者 临床和科学导师库。培训后的职业建议和指导将有助于安置 为 FAVOR 学员提供享有盛誉的奖学金和学术教职职位。 FAVOR 的全国影响 该计划将通过具有全面临床知识的受训者群体的科学成熟来实现 专业知识和杰出的转化科学，有能力应用转化免疫学来受益 器官移植受者。