Filling a Void of Research (FAVOR) Training for Transplant Surgeons

项目摘要/摘要 题为《填补移植外科医生研究培训空白》的Four T32将为外科手术做准备 在腹部和胸部移植手术方面从事转化性研究的住院医生。这一计划将 培训和激励一支独特的外科医生-科学家干部队伍，将床边敏锐的观察转化为 手术室，并在临床上转化为新的假说，可以通过免疫学重点询问 翻译研究。该计划的重点是独特的，满足不断增长的需求，以培训下一代 移植外科医生-可以为新兴的翻译和个性化领域做出贡献的科学家 医药。有利的结构是为了扭转这一令人沮丧的趋势，导致只有1.8%的AST接受过外科培训 成功竞争NIH-K系列奖的研究员，尽管76%的人被激励花更多的时间在 研究(Engesbe等人，AJT 2010：10,191-193；Kirk&Fung，AJT 2011，11；191-193)。培训内容包括 临床研究设计、统计计算和数据库管理的核心课程 临床研究的研究、科学写作和生物统计学方法。恩惠T32还包括 专门的培训选修课，将根据长期目标和兴趣为每个学员量身定做。一个 来自加州大学旧金山分校的外科实习生小规模干部，所有培训赠款符合条件且高度多样化(约40%URM， 50%女性)，将被选中以备受青睐。我们亦会邀请其他学术机构的学员参加 竞争性申请培训名额，学员将投入两个全日制年限，没有显著差异 临床责任，面向研究、教育和培训。一个实习生时段/年也将有资格 注册一个1-2年的临床/转化医学学位课程。实习生将准备应用他们的 培训以加深对免疫系统的了解，以及开发新的、基于免疫的 与外科手术相关的诊断学、预后学、治疗学和临床方法 结果。在该计划中，他们还将学习如何开发和利用临床数据库 将手术结果与病理学和免疫学数据相结合。Bour的NIH资助的教职员工， 在免疫学和翻译研究方面的杰出记录被特别挑选出来，以激励 并指导学员进行翻译指导研究，从以下每个项目中挑选2名导师/学员 临床和科学导师人才库。培训后的职业建议和指导将有助于就业 为受训人员提供享有盛名的奖学金和学术教师职位。这一优惠对全国的影响 计划将通过科学成熟的实习生群体实现，具有全面的临床 专业知识和杰出的翻译科学，有能力应用翻译免疫学来受益 器官移植接受者。

PROJECT SUMMARY/ABSTRACT The FAVOR T32 titled “Filling a Void of Research Training for Transplant Surgeons” will prepare surgical residents for translational research careers in abdominal and thoracic transplant surgery. This program will train and inspire a unique cadre of surgeon-scientists to translate astute observations at the bedside, in the operating room, and in the clinic into novel hypotheses that can be interrogated through immunology-focused translational research. This program is uniquely focused, serving a growing need to train the next generation of transplant surgeon-scientists that can contribute to the burgeoning field of translational and personalized medicine. FAVOR is structured to reverse the dismal trend resulting in only 1.8% of ASTS trained surgical fellows successfully competing for NIH-K series awards, despite 76% being motivated to spend more time in research (Englesbe et al., AJT 2010:10, 191-193; Kirk & Feng, AJT 2011, 11; 191-193). The training includes core courses in Designing Clinical Research, Statistical Computing and Database Management in Clinical Research, Scientific Writing, and Biostatistical Methods for Clinical Research. The FAVOR T32 also includes specialized training electives, which will be tailored to each trainee based on long-term goals and interests. A small cadre of surgical trainees from within UCSF, all training grant eligible and highly diverse (~40% URM, 50% female), will be selected for FAVOR. We will also invite trainees from other academic institutions by competitive application for training slots, where trainees will dedicate two full-time years, without significant clinical responsibilities, towards research education and training. One trainee slot/year will also be eligible to enroll in a 1-2 year degree course in Clinical/Translational Medicine. Trainees will be prepared to apply their training to deepen understanding of the immune system, as well as developing new, immune-based diagnostics, prognostics, therapeutics and clinical approaches that are relevant to surgical procedures and outcomes. While in the program they will also learn how to develop and draw upon clinical databases that integrate surgical outcomes with data from pathology and immunology. FAVOR's NIH-funded faculty, with distinguished track records in immunology and translational research, have been specially selected to inspire and guide trainees in translational mentored research, with selection of 2 mentors/trainee from each of the clinical and scientific mentor pools. Post-training career advice and guidance will facilitate placement into prestigious fellowships and academic faculty positions for FAVOR trainees. The national impact of the FAVOR program will be realized through the scientific maturation of a trainee group with comprehensive clinical expertise and outstanding translational science, with the ability to apply translational immunology to benefit organ transplant recipients.