Effects of physical activity on cardiometabolic impairments associated with insufficient sleep

体力活动对与睡眠不足相关的心脏代谢损伤的影响

基本信息

批准号：
9162426
负责人：
Josiane Broussard
金额：
$ 16.23万
依托单位：
UNIVERSITY OF COLORADO
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-29 至 2019-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9162426
关键词：
Adult Adverse effects American Anti-Inflammatory Agents Anti-inflammatory Antioxidants Behavior Behavioral Biology Cardiovascular Diseases Cardiovascular system Circadian Rhythms Clinical Research Data Data Analyses Development Diabetes Mellitus Diagnosis Diet Disease Energy Metabolism Event Exercise Physiology Funding Future General Population Genes Health Hour Human Impairment Individual Inflammation Inflammatory Insulin Insulin Resistance Intervention Laboratory Study Learning Mediating Memory Metabolic Metabolic Diseases Metabolism Military Personnel Molecular Nervous System Physiology Neuraxis Newborn Infant Non-Insulin-Dependent Diabetes Mellitus Nonesterified Fatty Acids Obesity Oxidative Stress Parents Persons Physical activity Physiological Physiology Play Prevention strategy Public Health Research Residencies Risk Factors Role Schedule Sleep Societies System Testing Time Tissues Training Travel Triglycerides United States Work aggressive therapy career cytokine disorder risk emergency service responder endothelial dysfunction fasting glucose glucose metabolism improved insulin sensitivity low density lipoprotein inhibitor novel obesity risk oral glucose tolerance oxidized low density lipoprotein prevent shift work treatment strategy

项目摘要

PROJECT SUMMARY/ABSTRACT Background: Rates of obesity in the United States have doubled over the last 30 years, as has the percentage of persons in the U.S. with diagnosed Type 2 diabetes mellitus (T2DM), and both conditions are rapidly increasing worldwide. Although changes in diet and energy expenditure have played an important role, sleep deficiency and circadian misalignment are risk factors for the development of obesity, insulin resistance and T2DM. Humans spend up to one third of their lives asleep and yet the function of sleep remains a topic of intense debate. While evidence supports a role for sleep in learning, memory and other central nervous system functions, well-controlled laboratory studies have demonstrated that sleep restriction has adverse effects on metabolism, both at the whole body, as well as molecular level. However, few studies to date have examined countermeasures to sleep loss and associated circadian misalignment. Research: The proposed study will assess the role of physical activity in mitigating physiological impairments associated with insufficient sleep, as well as provide complimentary training necessary to pursue a future independent scientific career at the intersection of metabolism and sleep/circadian biology.

项目摘要/摘要背景：在过去30年中，美国的肥胖率增加了一倍，美国患有诊断为2型糖尿病（T2DM）的人，这两种情况均迅速在全球范围内增加。尽管饮食和能量消耗的变化起着重要作用，但睡眠缺乏症和昼夜节律是肥胖，胰岛素抵抗和 T2DM。人类的一生中最多三分之一，但睡眠的功能仍然是一个话题激烈的辩论。虽然证据支持睡眠在学习，记忆和其他中枢神经系统中的作用功能，控制良好的实验室研究表明，睡眠限制对代谢，无论是在整个身体还是分子水平。但是，迄今为止很少有研究检查与睡眠损失和相关昼夜节律错位的对策。研究：拟议的研究将评估体育活动在减轻生理障碍中的作用与睡眠不足以及提供未来所需的免费培训有关在代谢与睡眠/昼夜节律生物学的交集中独立的科学职业。