Effects of physical activity on cardiometabolic impairments associated with insufficient sleep

项目总结/摘要 背景：在过去的30年里，美国的肥胖率翻了一番， 2型糖尿病（T2 DM）的患者，并且这两种病症都迅速地 在全球范围内增加。虽然饮食和能量消耗的变化发挥了重要作用，但睡眠 缺乏和昼夜节律失调是肥胖、胰岛素抵抗和 2型糖尿病。人类一生中有三分之一的时间是在睡眠中度过的，然而睡眠的功能仍然是一个 激烈的辩论。虽然有证据支持睡眠在学习，记忆和其他中枢神经系统中的作用， 严格控制的实验室研究表明，睡眠限制对睡眠功能有不利影响。 新陈代谢，无论是在整个身体，以及分子水平。然而，迄今为止，很少有研究检查 睡眠不足和相关的昼夜节律失调的对策。 研究：拟议的研究将评估体育活动在减轻生理损伤方面的作用 与睡眠不足有关，并提供必要的免费培训，以追求未来 在代谢和睡眠/昼夜节律生物学的交叉点独立的科学生涯。

PROJECT SUMMARY/ABSTRACT Background: Rates of obesity in the United States have doubled over the last 30 years, as has the percentage of persons in the U.S. with diagnosed Type 2 diabetes mellitus (T2DM), and both conditions are rapidly increasing worldwide. Although changes in diet and energy expenditure have played an important role, sleep deficiency and circadian misalignment are risk factors for the development of obesity, insulin resistance and T2DM. Humans spend up to one third of their lives asleep and yet the function of sleep remains a topic of intense debate. While evidence supports a role for sleep in learning, memory and other central nervous system functions, well-controlled laboratory studies have demonstrated that sleep restriction has adverse effects on metabolism, both at the whole body, as well as molecular level. However, few studies to date have examined countermeasures to sleep loss and associated circadian misalignment. Research: The proposed study will assess the role of physical activity in mitigating physiological impairments associated with insufficient sleep, as well as provide complimentary training necessary to pursue a future independent scientific career at the intersection of metabolism and sleep/circadian biology.