Effects of physical activity on cardiometabolic impairments associated with insufficient sleep

项目摘要/摘要 背景资料：在过去的30年里，美国的肥胖率翻了一番， 在美国，患有2型糖尿病(T2 DM)的人，这两种情况都很快 在全球范围内不断增加。尽管饮食和能量消耗的变化起到了重要作用，但睡眠 缺乏和昼夜节律失调是肥胖、胰岛素抵抗和 T2 DM。人类一生中有三分之一的时间在睡觉，然而睡眠的功能仍然是一个 激烈的辩论。虽然有证据支持睡眠在学习、记忆和其他中枢神经系统中的作用 功能，良好控制的实验室研究表明，睡眠限制对 新陈代谢，包括全身和分子水平。然而，到目前为止，很少有研究检查 睡眠不足和相关的昼夜节律失调的对策。 研究：拟议中的研究将评估体育活动在减轻生理损伤中的作用 与睡眠不足相关的，以及提供追求未来所需的免费培训 在新陈代谢和睡眠/昼夜生物学的交叉点上的独立科学生涯。

PROJECT SUMMARY/ABSTRACT Background: Rates of obesity in the United States have doubled over the last 30 years, as has the percentage of persons in the U.S. with diagnosed Type 2 diabetes mellitus (T2DM), and both conditions are rapidly increasing worldwide. Although changes in diet and energy expenditure have played an important role, sleep deficiency and circadian misalignment are risk factors for the development of obesity, insulin resistance and T2DM. Humans spend up to one third of their lives asleep and yet the function of sleep remains a topic of intense debate. While evidence supports a role for sleep in learning, memory and other central nervous system functions, well-controlled laboratory studies have demonstrated that sleep restriction has adverse effects on metabolism, both at the whole body, as well as molecular level. However, few studies to date have examined countermeasures to sleep loss and associated circadian misalignment. Research: The proposed study will assess the role of physical activity in mitigating physiological impairments associated with insufficient sleep, as well as provide complimentary training necessary to pursue a future independent scientific career at the intersection of metabolism and sleep/circadian biology.