Genetic and Epidemiological Approaches to Breast Density and Breast Cancer Risk

乳腺密度和乳腺癌风险的遗传学和流行病学方法

• 批准号: 9115081
• 负责人: Elad Ziv
• 金额: $ 17.82万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-09 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9115081
• 关键词: Affect; Age; Biological; Breast; Breast Cancer Risk Factor; Case-Control Studies; Complex; Data Set; Environmental Risk Factor; Epidemiology; Faculty; Family; Family history of; Family member; Genes; Genetic; Genetic Predisposition to Disease; Genetic study; Genome; Latina; Malignant Neoplasms; Mammographic Density; Medicine; Mentors; Participant; Pathway interactions; Play; Postdoctoral Fellow; Predisposition; Recording of previous events; Research Personnel; Role; Sampling; Students; Training; Twin Studies; Variant; Woman; Work; base; breast density; cancer genome; cancer risk; density; exome sequencing; genetic variant; genome wide association study; high risk; malignant breast neoplasm; member; mid-career faculty; next generation; next generation sequencing; patient oriented research; programs; rare variant; research study; skills; trait

DESCRIPTION (provided by applicant): The applicant, Dr. Elad Ziv, is an associate professor of medicine at UCSF and leads a patient oriented research program that investigates genetic susceptibility to common cancers and hematological traits. A major focus of Dr. Ziv's program is the study of genetic factors underlying breast cancer susceptibility. As part of this proposal, Dr. Ziv will search for genetic factors underlying the association between mammographic breast density and breast cancer risk. Mammographic breast density is known to be a strong risk factor for breast cancer and is also a highly heritable trait. Dr. Ziv will analyze a large genome wide association study (GWAS) that his group is generating, comparing 500 women from the top quintile of age and BMI-adjusted breast density to 500 women from the bottom quintile. He will perform a replication analysis of the top 1500 variants in a replication dataset of another 500 women from the top and 500 women from the bottom quintile of age and BMI adjusted density. In addition, his group will search for genetic variants that are associated with both breast densit and breast cancer risk. They will perform a combined analysis of breast density and breast cancer GWAS datasets, using GWAS datasets of breast cancer susceptibility that his group has generated and a publicly available breast cancer GWAS datasets. Dr. Ziv and colleagues will also use next generation sequencing to search for rare variants that may explain the overlap between these traits. In particular, women with a strong family history of breast cancer who are also in the top quintile of age and BMI-adjusted breast density will be selected for whole exome sequencing. As part of this proposal, Dr. Ziv will expand his capacity to mentor junior investigators and develop additional skills to maximize his potential as a mentor. Dr. Ziv has mentored over 15 junior faculty members, fellows, residents and students. He is affiliated with 3 T32 programs for mentoring fellows. As part of this proposal, Dr. Ziv will take on additional mentees at the post-doctoral level and continue to mentor the junior faculty, fellows currently working with him. He will also pursue additional training that will enhance his mentoring and scientific skills.

描述（由申请人提供）：申请人Elad Ziv博士是加州大学旧金山分校的医学副教授，领导一个以患者为导向的研究项目，研究常见癌症和血液学特征的遗传易感性。Ziv博士项目的一个主要重点是研究乳腺癌易感性的遗传因素。作为这项提议的一部分。