Neonatal ABRs and Heritable Risk for ASD

新生儿 ABR 和 ASD 遗传风险

• 批准号: 9316041
• 负责人: Nicole Talge
• 金额: $ 23.25万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9316041
• 关键词: Acoustics; Address; Age; Age-Months; Attentional deficit; Auditory Brainstem Responses; Auditory Perception; Base of the Brain; Behavior; Behavioral; Biological Markers; Brain; Brain Stem; CNS processing; Cell Nucleus; Cephalic; Child; Cochlea; Data; Diagnosis; Diagnostic; Disease; Early Intervention; Early identification; Electrophysiology (science); Eligibility Determination; Equipment; Esthesia; Etiology; Event-Related Potentials; Exhibits; Feasibility Studies; First Degree Relative; Gestational Age; Goals; Heritability; Hospitals; Impairment; Individual; Infant; Intervention; Investigation; Lead; Literature; Longitudinal Studies; Measurable; Measures; Medical; Neonatal; Neurodevelopmental Disorder; Neurons; Participant; Pilot Projects; Predictive Value; Prevalence; Process; Prognostic Marker; Property; Protocols documentation; Public Health; Recommendation; Recruitment Activity; Research; Response Latencies; Risk; Risk Assessment; Siblings; Sparrows; Stimulus; Structure; Symptoms; Time; Ultrasonography; United States; Visit; auditory pathway; auditory processing; auditory stimulus; autism onset; autism spectrum disorder; base; disorder risk; evidence base; hearing screening; high risk; infancy; intervention program; joint attention; middle ear; myelination; population based; postnatal; prenatal; prognostic; prognostic value; programs; restrictive repetitive behavior; service intervention; sex; social communication; stimulus processing; trend

Abstract The goal of this proposal is to evaluate the feasibility of measuring click-evoked auditory brainstem responses (ABRs) among infants who vary in heritable risk for autism spectrum disorder (ASD) and to calculate preliminary estimates of effect size. Click-evoked ABRs are event-related potentials that reflect the electrophysiological processing of broadband acoustic stimuli (i.e., clicks) from the cochlea through the rostral brainstem. ABRs consist of 5 distinct waves (I-V) from which latencies and amplitudes can be derived, values thought to reflect the degree of dendritic branching, myelination, and synchrony of neuronal firing between nuclei in the central auditory pathway. Studies suggest that click-evoked ABR parameters and ASD are associated and that these associations are medium to large in size, particularly in children. However, it is unclear whether ABR alterations precede ASD diagnosis. To address this conceptual and empirical gap in the literature, we will compare ABR parameters between two groups of infants who vary in heritable risk for ASD: 1) babies who have an older sibling diagnosed with ASD (higher risk; n=18), and 2) gestational age- and sex- matched babies who do not have any siblings diagnosed with ASD (lower risk; n=18). Participants will be recruited at Sparrow Hospital (Lansing, MI) and invited to participate in a lab visit at one month of age (+ 1 week). At this lab visit, a licensed audiologist will perform a comprehensive middle ear examination, an ABR threshold screen, and a diagnostic-level ABR. If the etiologic and/or predictive value of ABRs is supported in subsequent investigations, the research initiated with this project has the potential to transform ASD risk surveillance and access to early interventions.

摘要 本建议的目的是评估的可行性测量点击诱发听觉脑干反应 在自闭症谱系障碍（ASD）遗传风险不同的婴儿中， 效应量的初步估计。点击诱发的ABR是事件相关电位，其反映了 宽带声刺激的电生理学处理（即，从耳蜗到喙部 脑干ABR由5个不同的波（I-V）组成，从这些波可以导出潜伏期和振幅， 这被认为反映了树突分支的程度，髓鞘形成，以及神经元放电的同步性。 中枢听觉通路的神经核。研究表明，点击诱发的ABR参数和ASD是 这些协会是中等至大规模的，特别是在儿童中。但据 不清楚ABR改变是否先于ASD诊断。为了解决这一概念和经验上的差距， 在文献中，我们将比较ASD遗传风险不同的两组婴儿之间的ABR参数： 1)有一个年长的兄弟姐妹被诊断为ASD的婴儿（风险较高; n=18），以及2）胎龄和性别- 没有任何兄弟姐妹被诊断为ASD的匹配婴儿（风险较低; n=18）。参与者将被 在Sparrow医院（兰辛，密歇根州）招募，并在1月龄（+1）时被邀请参加实验室访问 周）。在这次实验室访视中，有执照的听力学家将进行全面的中耳检查， 阈值筛选和诊断级别的ABR。如果ABR的病因学和/或预测价值在以下研究中得到支持， 随后的调查，该项目启动的研究有可能改变ASD风险 监测和获得早期干预。