The role of African Green Monkeys in the epidemiology of Dengue and Chikungunya on St Kitts, West Indies

非洲绿猴在西印度群岛圣基茨登革热和基孔肯雅热流行病学中的作用

基本信息

  • 批准号:
    9226818
  • 负责人:
  • 金额:
    $ 16.59万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-12-19 至 2018-11-30
  • 项目状态:
    已结题

项目摘要

Chikungunya and dengue are important viral diseases that affect over 50 million people each year in the tropical and subtropical areas of the world. The chikungunya and dengue viruses evolved in non-human primates in the forests of Africa and Asia where forest mosquitoes maintained the viruses in a monkey-to-monkey (sylvatic) transmission cycle. It is only in the last few hundred years that the viruses began to infect people and their domestic and peri-domestic mosquitoes and be maintained in a human-to-human (urban) transmission cycle. A lot is known about the human mosquitoes that carry dengue and chikungunya and control programs have been developed to try and prevent and control infections. Unfortunately, there is little data on the roles wild non-human primates and their mosquitoes play in transmission cycles as they are mainly found in relatively remote areas which lack local infrastructure and facilities for research. On the small Caribbean island of St Kitts, however, there is a large population of wild African green monkeys which are ubiquitous and relatively easy to study. Also, the island is easily accessible and has very good infrastructure and research facilities for the study of dengue and chikungunya which both occur on St Kitts. To investigate the role African green monkeys on St Kitts may play in sylvatic and urban transmission cycles of chikungunya and dengue viruses we intend to trap mosquitoes from each of the five well demarcated ecosystems on the island over two years to determine the mosquitoes present and their temporal and spatial distribution patterns. Pools of the mosquitoes will be tested for the presence of dengue and chikungunya viruses to determine which species are infected and hence likely vectors, and also where on the island infections are most common. Blood meals from fed mosquitoes will be analyzed by PCR to determine the animal hosts on which the different mosquito species feed, in particular monkeys and people. African green monkeys from the five ecosystems on the island will be tested for antibodies against dengue and chikungunya viruses to determine the pattern of exposure on the island. Together, this information will indicate if the African green monkeys on St Kitts might be involved in sylvatic and urban transmission cycles of dengue and chikungunya viruses and whether non-human primates might be important in the epidemiology of dengue and chikungunya in other parts of the world, notably Africa, Asia and South America, where people live in close proximity to wild populations of non-human primates.
基孔肯雅热和登革热是重要的病毒性疾病,分别影响5000多万人 在世界热带和亚热带地区的一年。基孔肯雅病毒和登革热病毒 在非洲和亚洲的森林里, 使病毒保持在猴-猴(森林)传播周期中。只是近 几百年来,病毒开始感染人类及其家庭和周边地区, 蚊子,并保持在人与人(城市)的传播周期。我们知道很多 关于携带登革热和基孔肯雅病的人类蚊子以及控制计划, 用来预防和控制感染不幸的是,关于这些角色的数据很少。 野生非人类灵长类动物和它们的蚊子在传播周期中玩耍,因为它们主要是 在缺乏当地基础设施和研究设施的相对偏远地区发现。上 然而,在加勒比海的一个小岛圣基茨岛上,却生活着大量的野生非洲绿色 猴子是普遍存在的,相对容易研究。此外,岛上很容易到达 并且有很好的基础设施和研究设施来研究登革热和基孔肯雅热 都发生在圣基茨岛 为了调查圣基茨岛上非洲绿色猴在森林和城市中的作用, 基孔肯雅病毒和登革热病毒的传播周期,我们打算从每个地方诱捕蚊子。 在岛上五个界限分明的生态系统中, 及其时空分布规律。10%的蚊子将接受测试 登革热和基孔肯雅病毒的存在,以确定哪些物种受到感染, 因此可能是病媒,而且在岛上感染最常见的地方。血粉 将通过PCR分析来自喂食的蚊子的病毒,以确定病毒在其上的动物宿主。 不同种类的蚊子捕食,特别是猴子和人。非洲绿色猴从 岛上的五个生态系统将进行登革热和基孔肯雅病抗体测试, 病毒来确定岛上的暴露模式总之,这些信息将 表明圣基茨岛上的非洲绿色猴子是否可能参与森林和城市的 登革热和基孔肯雅病毒的传播周期以及非人类灵长类动物是否可能 在世界其他地区的登革热和基孔肯雅病流行病学中发挥重要作用, 非洲,亚洲和南美洲,那里的人们生活在靠近野生种群的地方, 非人类灵长类动物

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Patrick Kelly其他文献

Patrick Kelly的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Patrick Kelly', 18)}}的其他基金

Transmission of Rickettsia africae by Amblyomma americanum and Amblyomma maculatum
美洲钝眼虫和斑钝眼虫传播非洲立克次体
  • 批准号:
    9894993
  • 财政年份:
    2020
  • 资助金额:
    $ 16.59万
  • 项目类别:
Phase II: Feasibility assessment of a novel tool for mosquito vector control: Auto-Dissemination Augmented by Males (ADAM)
第二阶段:蚊媒控制新工具的可行性评估:雄性自动传播(ADAM)
  • 批准号:
    9255783
  • 财政年份:
    2014
  • 资助金额:
    $ 16.59万
  • 项目类别:

相似海外基金

Multi-component interventions to reducing unhealthy diets and physical inactivity among adolescents and youth in sub-Saharan Africa (Generation H)
采取多方干预措施减少撒哈拉以南非洲青少年的不健康饮食和缺乏身体活动(H 代)
  • 批准号:
    10106976
  • 财政年份:
    2024
  • 资助金额:
    $ 16.59万
  • 项目类别:
    EU-Funded
Exploring the mental health and wellbeing of adolescent parent families affected by HIV in South Africa
探讨南非受艾滋病毒影响的青少年父母家庭的心理健康和福祉
  • 批准号:
    ES/Y00860X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 16.59万
  • 项目类别:
    Fellowship
Decolonization, Appropriation and the Materials of Literature in Africa and its Diaspora
非洲及其侨民的非殖民化、挪用和文学材料
  • 批准号:
    EP/Y024516/1
  • 财政年份:
    2024
  • 资助金额:
    $ 16.59万
  • 项目类别:
    Research Grant
Exploring "Actionable Information" for Learning Improvement in Rural East Africa: A Positive Deviance Approach
探索东非农村地区学习改进的“可行信息”:积极偏差方法
  • 批准号:
    24K00390
  • 财政年份:
    2024
  • 资助金额:
    $ 16.59万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
ePowerCart - Affordable Mobile Clean Energy for Remote Communities in Rural Sub-Saharan Africa and India
ePowerCart - 为撒哈拉以南非洲和印度农村偏远社区提供经济实惠的移动清洁能源
  • 批准号:
    10076185
  • 财政年份:
    2024
  • 资助金额:
    $ 16.59万
  • 项目类别:
    Collaborative R&D
Protecting Women from Economic shocks to fight HIV in Africa (POWER)
保护非洲妇女免受经济冲击,抗击艾滋病毒 (POWER)
  • 批准号:
    MR/Y003837/1
  • 财政年份:
    2024
  • 资助金额:
    $ 16.59万
  • 项目类别:
    Fellowship
Tackling antimicrobial resistance across dentistry in Sub-Saharan Africa.
解决撒哈拉以南非洲牙科领域的抗菌素耐药性问题。
  • 批准号:
    MR/Y019695/1
  • 财政年份:
    2024
  • 资助金额:
    $ 16.59万
  • 项目类别:
    Research Grant
Water stressed cities: individual choice, access to water and pathways to resilience in sub-Saharan Africa
缺水城市:撒哈拉以南非洲地区的个人选择、水资源获取和恢复力途径
  • 批准号:
    MR/X022943/1
  • 财政年份:
    2024
  • 资助金额:
    $ 16.59万
  • 项目类别:
    Fellowship
The Open fracture National Evaluation (ONE) Study - South Africa: Improving outcomes in the care of open fractures in low resource settings
开放性骨折国家评估 (ONE) 研究 - 南非:改善资源匮乏地区开放性骨折的护理效果
  • 批准号:
    MR/Y00955X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 16.59万
  • 项目类别:
    Fellowship
Recognising & supporting informal mhealth in Africa through grassroots interventions (REIMAGINE)
认识
  • 批准号:
    MR/Y015614/1
  • 财政年份:
    2024
  • 资助金额:
    $ 16.59万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了