Training in the Genetics and Genomics of Mental Disorders

精神疾病遗传学和基因组学培训

• 批准号: 9386891
• 负责人: John P. Rice
• 金额: $ 0.07万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9386891
• 关键词: Genetic; Genomics; Mental disorders; Training

 DESCRIPTION (provided by applicant): This application requests a further five years of support for an Institutional National Research Service Award to support multidisciplinary post-doctoral training in Genetic Epidemiology, Molecular Genetics and Neurobiology. We request support for four postdoctoral (1 M.D. and 3 Ph.D.) fellows for training in Genetic Methodology, Family Epidemiology and Behavior Genetics, Gene Mapping and Bioinformatics, Molecular Genetics, and Genomics. In addition to training in a primary area, fellows will be encouraged to obtain a broad understanding of the diverse skills in Psychiatric Genetics to facilitate their collaboration in (and leadership of) cross- disciplinary research teams. The fellowship will usually last three years, but one or two years may suffice for those with much pertinent experience. Fellows with a wide variety of backgrounds will be recruited including; Psychology, Psychiatry, Genetics, Statistics, Mathematics, Anthropology, Sociology, Biology, and Neuroscience. The training program uses an apprenticeship model, combining research under the mentorship of one or more experienced mentors with more formal training through seminars, didactic courses and individual reading. Major strengths of the program are; (i) the participation of a large multidisciplinary group of well-funded preceptors (n=23) with expertise in statistical and computational genetics, molecular genetics and neuroscience; (ii) the study of quantitative and qualitative traits and the development of methods for the analysis of multivariate phenotypes and (iii) the availability of major epidemiological and genetic data sets (phenotypes and genotypes). Fellows may participate in ongoing Genome-Wide Association Studies (GWAS) of Schizophrenia, Bipolar Disorder, Alzheimer's Disease, Autism, ADH, Electrophysiological measures of CNS activity, Personality traits and Nicotine Dependence. We anticipate analysis of sequence data to become a future emphasis. Preceptors in this program have many federally and non-federally funded grants providing many opportunities for training in all aspects of Psychiatric Genetics. The program is located in one of the nation's leading Medical Schools with a rich array of basic and applied genetic research studies and educational opportunities. Thus, we expect the long tradition of successful mentoring and research training of scientists and physician-scientists from diverse intellectual backgrounds to continue.

 描述（由应用程序提供）：本申请要求另外五年支持机构国家研究服务奖，以支持遗传流行病学，分子遗传学和神经生物学的多学科博士后培训。我们要求支持四个博士后（1 M.D.和3 Ph.D.）研究员，以培训遗传学方法论，家庭流行病学和行为遗传学，基因图和生物信息学，分子遗传学和基因组学。除了在主要领域进行培训外，还将鼓励研究员对精神遗传学领域的潜水员技能有广泛的了解，以促进他们在跨学科研究团队（和领导）的合作。奖学金通常会持续三年，但是对于那些有很多相关经验的人来说，一两年可能就足够了。将招募具有各种背景的研究员；心理学，精神病学，遗传学，统计学，数学，人类学，社会学，生物学和神经科学。培训计划使用学徒模型，将一个或多种经验丰富的心态的研究与通过精神疗程，教学课程和个人阅读进行更正式的培训相结合。该计划的主要优势是； （i）在统计和计算遗传学，分子遗传学和神经科学方面具有专业知识的大型跨学科群体（n = 23）的参与； （ii）对定量和定性性状的研究以及分析多元表型的方法的发展以及（iii）主要流行病学和遗传数据集（表型和基因型）的可用性。研究员可能会参与精神分裂症，双相情感障碍，阿尔茨海默氏病，自闭症，ADH，中枢神经系统活性，人格特质和尼古丁依赖性的电生理测量的持续的全基因组关联研究（GWAS）。我们预计对序列数据的分析将成为未来的重点。该计划中的主持人有许多联邦和非养育资金的赠款，为精神遗传学各个方面提供了许多培训机会。该计划位于全国一所领先的医学院之一，拥有丰富的基础和应用遗传研究和教育机会。这就是我们期望从不同智力背景的科学家和身体科学家成功进行心理和研究培训的悠久传统。