Training in the Genetics and Genomics of Mental Disorders

精神疾病遗传学和基因组学培训

• 批准号: 9386891
• 负责人: John P. Rice
• 金额: $ 0.07万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9386891
• 关键词: Genetic; Genomics; Mental disorders; Training

 DESCRIPTION (provided by applicant): This application requests a further five years of support for an Institutional National Research Service Award to support multidisciplinary post-doctoral training in Genetic Epidemiology, Molecular Genetics and Neurobiology. We request support for four postdoctoral (1 M.D. and 3 Ph.D.) fellows for training in Genetic Methodology, Family Epidemiology and Behavior Genetics, Gene Mapping and Bioinformatics, Molecular Genetics, and Genomics. In addition to training in a primary area, fellows will be encouraged to obtain a broad understanding of the diverse skills in Psychiatric Genetics to facilitate their collaboration in (and leadership of) cross- disciplinary research teams. The fellowship will usually last three years, but one or two years may suffice for those with much pertinent experience. Fellows with a wide variety of backgrounds will be recruited including; Psychology, Psychiatry, Genetics, Statistics, Mathematics, Anthropology, Sociology, Biology, and Neuroscience. The training program uses an apprenticeship model, combining research under the mentorship of one or more experienced mentors with more formal training through seminars, didactic courses and individual reading. Major strengths of the program are; (i) the participation of a large multidisciplinary group of well-funded preceptors (n=23) with expertise in statistical and computational genetics, molecular genetics and neuroscience; (ii) the study of quantitative and qualitative traits and the development of methods for the analysis of multivariate phenotypes and (iii) the availability of major epidemiological and genetic data sets (phenotypes and genotypes). Fellows may participate in ongoing Genome-Wide Association Studies (GWAS) of Schizophrenia, Bipolar Disorder, Alzheimer's Disease, Autism, ADH, Electrophysiological measures of CNS activity, Personality traits and Nicotine Dependence. We anticipate analysis of sequence data to become a future emphasis. Preceptors in this program have many federally and non-federally funded grants providing many opportunities for training in all aspects of Psychiatric Genetics. The program is located in one of the nation's leading Medical Schools with a rich array of basic and applied genetic research studies and educational opportunities. Thus, we expect the long tradition of successful mentoring and research training of scientists and physician-scientists from diverse intellectual backgrounds to continue.

 描述（由申请人提供）：本申请要求再获得五年的机构国家研究服务奖支持，以支持遗传流行病学、分子遗传学和神经生物学方面的多学科博士后培训。我们请求支持四名博士后（1 名医学博士和 3 名博士）研究员进行遗传方法学、家庭流行病学和行为遗传学、基因图谱和生物信息学、分子遗传学和基因组学方面的培训。除了主要领域的培训外，还将鼓励研究员对精神遗传学的各种技能有广泛的了解，以促进他们在跨学科研究团队中的合作（和领导）。奖学金通常持续三年，但对于有很多相关经验的人来说，一两年就足够了。将招募具有各种背景的研究员，包括：心理学、精神病学、遗传学、统计学、数学、人类学、社会学、生物学和神经科学。该培训计划采用学徒模式，将一位或多位经验丰富的导师指导下的研究与通过研讨会、教学课程和个人阅读进行的更正式的培训相结合。该计划的主要优势是： (i) 一个大型多学科小组的参与，该小组由资金充足的导师组成（n=23），他们具有统计和计算遗传学、分子遗传学和神经科学方面的专业知识； (ii) 数量和质量特征的研究以及多变量表型分析方法的开发，以及 (iii) 主要流行病学和遗传数据集（表型和基因型）的可用性。研究员可以参加正在进行的精神分裂症、双相情感障碍、阿尔茨海默病、自闭症、ADH、中枢神经系统活动的电生理学测量、人格特质和尼古丁依赖的全基因组关联研究 (GWAS)。我们预计序列数据的分析将成为未来的重点。该计划的导师拥有许多联邦和非联邦资助的拨款，为精神病遗传学各个方面的培训提供了许多机会。该项目位于美国领先的医学院之一，拥有丰富的基础和应用遗传学研究和教育机会。因此，我们期望对来自不同知识背景的科学家和医师科学家进行成功指导和研究培训的悠久传统能够继续下去。