GENETIC LINKAGE STUDIES OF THE AFFECTIVE DISORDER

情感障碍的遗传连锁研究

基本信息

  • 批准号:
    2430940
  • 负责人:
  • 金额:
    $ 48.03万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1994
  • 资助国家:
    美国
  • 起止时间:
    1994-06-01 至 2000-05-31
  • 项目状态:
    已结题

项目摘要

This is a resubmission of a four year proposal from five clinical centers to conduct a genetic linkage study of the Affective Disorders. We will perform a third clinical assessment of relatives in 20 pedigrees systematically selected from 612 families of the NIMH Collaborative Depression Study. We will study 20 families with a least four interviewed members with primary major depression and none with mania or hypomania. These pedigrees will be extended to include 150 new relatives. Blood will be drawn for the establishment of lymphoblastoid cell lines and the preparation of high molecular weight DNA. Systematic mapping of the 20 pedigrees with a panel of highly polymorphic DNA markers spanning the entire human genome will be completed. Using both likelihood and non-parametric methods which allow for heterogeneity among pedigrees, genetic linkages between DNA markers and affective disorders will be identified using parameters obtained from segregation analysis. The proposed study has two unique aspects. First, it utilizes an existing collection of well characterized 'true breeding' pedigrees. Secondly, it utilizes repeated measures of family member diagnoses to modify segregation and linkage analyses. This provides increased precision in making final diagnoses and offers potential reduction of "false positives" particularly when considering the spectrum of depressive disorders. Simulation studies based on oligogenic transmission indicate we have sufficient power by increasing the heritability through reduction of the effects of measurement error. Moreover, by using families sampled in a systematic way, quantitative genetic methods may be applied to test for pedigree specific genetic and phenotypic heterogeneity. The discovery of linkage would help delineate the pathophysiology and developmental course of the affective disorders with the potential of successful early intervention. In this resubmission, we have removed the BP-II and mixed families, and focus only on the sample of 20 MDD pedigrees. We have identified an additional 35 MDD families that will serve as a "replacement" sample. Finally, we have dropped the PHDD and Medical History II Form and expanded our discussion of the reliability/validity of the other instruments and procedures.
这是来自五个临床中心的四年提案的重新提交

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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John P. Rice其他文献

A configuration-based approach to integrating dynamic capabilities and market transformation in small and medium-sized enterprises to achieve firm performance
基于配置的方法,整合中小企业的动态能力和市场转型,以实现企业绩效
  • DOI:
    10.1177/0266242613495035
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    0
  • 作者:
    John P. Rice;Tung;P. Galvin;Nigel J. Martin
  • 通讯作者:
    Nigel J. Martin
The Vicissitudes of Competitive Advantage: Empirical Evidence from Australian Manufacturing SMEs*
竞争优势的变迁:来自澳大利亚中小企业的经验证据*
OPENNESS IN PRODUCT AND PROCESS INNOVATION
产品和工艺创新的开放性
  • DOI:
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Fang;John P. Rice
  • 通讯作者:
    John P. Rice
Voltage-gated calcium channel activity and complex related genes and schizophrenia: A systematic investigation based on Han Chinese population
电压门控钙通道活性及复杂相关基因与精神分裂症:基于汉族人群的系统调查
  • DOI:
    10.1016/j.jpsychires.2018.09.020
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    4.8
  • 作者:
    Tianxiao Zhang;Li Zhu;Tong Ni;Dan Liu;Gang Chen;Zhilan Yan;Huali Lin;Fanglin Guan;John P. Rice
  • 通讯作者:
    John P. Rice
Exploring CBD Retail Performance, Recovery and Resilience of a Smart City Following COVID-19
探索 COVID-19 后智慧城市的 CBD 零售绩效、恢复和弹性
  • DOI:
    10.3390/su15108300
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    3.9
  • 作者:
    P. Fieger;G. Prayag;D. Dyason;John P. Rice;C. M. Hall
  • 通讯作者:
    C. M. Hall

John P. Rice的其他文献

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{{ truncateString('John P. Rice', 18)}}的其他基金

Training in the Genetics and Genomics of Mental Disorders
精神疾病遗传学和基因组学培训
  • 批准号:
    9386891
  • 财政年份:
    2016
  • 资助金额:
    $ 48.03万
  • 项目类别:
A Collaborative Genomic Study of Bipolar Disorder
双相情感障碍的合作基因组研究
  • 批准号:
    7183495
  • 财政年份:
    1998
  • 资助金额:
    $ 48.03万
  • 项目类别:
A Collaborative Genomic Study of Bipolar Disorder
双相情感障碍的合作基因组研究
  • 批准号:
    6873667
  • 财政年份:
    1998
  • 资助金额:
    $ 48.03万
  • 项目类别:
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER
双相情感障碍的合作基因组研究
  • 批准号:
    6392426
  • 财政年份:
    1998
  • 资助金额:
    $ 48.03万
  • 项目类别:
A Collaborative Genomic Study of Bipolar Disorder
双相情感障碍的合作基因组研究
  • 批准号:
    6989088
  • 财政年份:
    1998
  • 资助金额:
    $ 48.03万
  • 项目类别:
A Collaborative Genomic Study of Bipolar Disorder
双相情感障碍的合作基因组研究
  • 批准号:
    6720903
  • 财政年份:
    1998
  • 资助金额:
    $ 48.03万
  • 项目类别:
GENETIC LINKAGE STUDIES OF THE AFFECTIVE DISORDER
情感障碍的遗传连锁研究
  • 批准号:
    2248934
  • 财政年份:
    1994
  • 资助金额:
    $ 48.03万
  • 项目类别:
GENETIC LINKAGE STUDIES OF THE AFFECTIVE DISORDER
情感障碍的遗传连锁研究
  • 批准号:
    2248932
  • 财政年份:
    1994
  • 资助金额:
    $ 48.03万
  • 项目类别:
GENETIC LINKAGE STUDIES OF THE AFFECTIVE DISORDER
情感障碍的遗传连锁研究
  • 批准号:
    2248933
  • 财政年份:
    1994
  • 资助金额:
    $ 48.03万
  • 项目类别:
Data Management Core
数据管理核心
  • 批准号:
    10238798
  • 财政年份:
    1989
  • 资助金额:
    $ 48.03万
  • 项目类别:
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