Emphysema and Inflammatory Biomarkers and Risk of Osteoporosis in Men with COPD

肺气肿和炎症生物标志物以及男性慢性阻塞性肺病患者骨质疏松症的风险

基本信息

  • 批准号:
    9337253
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-07-01 至 2019-06-30
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Low bone mineral density (BMD) is associated with chronic obstructive lung disease (COPD) independent of traditional osteoporosis risk factors, including physical inactivity, steroid use, ad cachexia. However, osteoporosis in men with COPD is often underdiagnosed due to lack of consensus on osteoporosis screening guidelines in this group of patients. Systemic inflammation plays a key role in the pathogenesis of both COPD and osteoporosis; but few studies have shown a relationship between specific systemic inflammatory biomarkers and either low BMD or accelerated loss of BMD over time. Immunologic alterations likewise contribute to the pathogenesis of both COPD and osteoporosis but the role of autoimmunity in COPD-related osteoporosis has not been studied. An independent association between low BMD and emphysema has been supported by the literature, but the mechanism for this association is unknown. This project's overall goal is to identify specific systemic inflammatory and autoimmune processes associated with both concurrent and progressive BMD loss and emphysema in men with COPD. This goal will be accomplished by establishing a two-year longitudinal c o h o r t o f m e n w i t h C O P D and attaining baseline and two-year assessments of BMD, radiographic emphysema, a n d pulmonary function. Inflammatory biomarker levels will be measured at six month intervals and during episodes of acute exacerbation of COPD (AECOPD). Systemic inflammatory and autoimmune biomarkers associated with BMD loss, measured by dual x-ray absorptiometry, emphysema progression, measured by quantitative CT scan, and incident hip or vertebral fractures over the two-year time interval will be identified. Changes in systemic inflammatory and autoimmune biomarker levels with AECOPD and the relationship to bone turnover and cumulative BMD loss will also be assessed. The findings from this project will identify criteria for male COPD patients at risk of accelerated BMD loss in whom early and serial BMD assessments may be beneficial, provide insight into pathogenic mechanisms linking COPD and osteoporosis, and provide novel targets for osteoporosis prevention and treatment strategies in men with COPD. This project will also address an unmet public health need given that most data on skeletal health are in women.
 描述(由申请人提供): 低骨矿物质密度(BMD)与慢性阻塞性肺疾病(COPD)相关,与传统的骨质疏松症风险因素无关,包括缺乏运动、类固醇使用、恶病质。然而,由于对COPD男性患者的骨质疏松症筛查指南缺乏共识,这类患者的骨质疏松症往往诊断不足。全身性炎症在COPD和骨质疏松症的发病机制中起着关键作用;但很少有研究表明特定的全身性炎症生物标志物与低BMD或BMD随时间加速丢失之间的关系。免疫学改变同样有助于COPD和骨质疏松症的发病机制,但自身免疫在COPD相关骨质疏松症中的作用尚未研究。低BMD和肺气肿之间的独立关联已得到文献的支持,但这种关联的机制尚不清楚。该项目的总体目标是确定与COPD男性患者并发和进行性BMD丢失和肺气肿相关的特定全身炎症和自身免疫过程。这一目标将通过建立一个为期两年的纵向C O P D模型,并获得基线和两年的BMD、放射学肺气肿和肺功能评估来实现。将在COPD急性加重(AECOPD)发作期间每6个月测量一次炎症生物标志物水平。将确定与BMD损失相关的全身炎症和自身免疫生物标志物,通过双X线吸收测定法测量,通过定量CT扫描测量肺气肿进展,以及在两年时间间隔内发生的髋关节或椎骨骨折。还将评估AECOPD患者全身炎症和自身免疫生物标志物水平的变化以及与骨转换和累积BMD丢失的关系。该项目的研究结果将确定有加速BMD丢失风险的男性COPD患者的标准,早期和连续的BMD评估可能是有益的,为COPD和骨质疏松症的致病机制提供深入了解,并为COPD男性骨质疏松症的预防和治疗策略提供新的靶点。鉴于大多数骨骼健康数据都是关于妇女的,该项目还将解决尚未满足的公共卫生需求。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

JESSICA BON其他文献

JESSICA BON的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('JESSICA BON', 18)}}的其他基金

Fungal Translocation in Chronic Obstructive Pulmonary Disease
慢性阻塞性肺疾病中的真菌移位
  • 批准号:
    10610446
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
Fungal Translocation in Chronic Obstructive Pulmonary Disease
慢性阻塞性肺疾病中的真菌移位
  • 批准号:
    10434243
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
Pittsburgh Innovation in Collaborative Training of Residents Alliance
匹兹堡居民联盟协作培训创新
  • 批准号:
    10608088
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Pittsburgh Innovation in Collaborative Training of Residents Alliance
匹兹堡居民联盟协作培训创新
  • 批准号:
    10350563
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
The impact of a home-based pulmonary telerehabilitation program on muscle function and quality of life following acute exacerbations of chronic obstructive pulmonary disease
家庭肺远程康复计划对慢性阻塞性肺疾病急性加重后肌肉功能和生活质量的影响
  • 批准号:
    10201778
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Autoimmunity and emphysema and risk of osteoporosis in smokers
吸烟者的自身免疫和肺气肿以及骨质疏松症的风险
  • 批准号:
    9916794
  • 财政年份:
    2016
  • 资助金额:
    --
  • 项目类别:
Emphysema and Inflammatory Biomarkers and Risk of Osteoporosis in Men with COPD
肺气肿和炎症生物标志物以及男性慢性阻塞性肺病患者骨质疏松症的风险
  • 批准号:
    9551566
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
Emphysema and Inflammatory Biomarkers and Risk of Osteoporosis in Men with COPD
肺气肿和炎症生物标志物以及男性慢性阻塞性肺病患者骨质疏松症的风险
  • 批准号:
    9932924
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
The Relationship Between Osteoporosis and Phenotypic Heterogeneity in COPD
骨质疏松症与慢性阻塞性肺病表型异质性的关系
  • 批准号:
    7903213
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:
The Relationship Between Osteoporosis and Phenotypic Heterogeneity in COPD
骨质疏松症与慢性阻塞性肺病表型异质性的关系
  • 批准号:
    8309992
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了