2016 Antibody Biology and Engineering Gordon Research Conference & Gordon Research Seminar

 描述(由申请人提供)：本申请寻求对2016年戈登抗体生物学和工程研究会议(GRC)以及将于2016年3月20-28日在德克萨斯州加尔维斯顿加尔韦斯酒店举行的戈登研究研讨会(GRS)的部分支持。这是关于这一主题的第四次GRC和第二次GRS，代表了社区中一次非常令人兴奋和有影响力的会议。本次会议的目的是在旨在最大限度地进行讨论和互动的非正式环境中，深入报道快速发展的抗体生物学和工程领域的重要最新发展。这一领域对广泛的生物学和临床重要课题有着广泛的影响。GRS将在GRC之前进行，并将专门为研究生和博士后科学家提供研讨会和海报会议，允许他们介绍和讨论他们的研究。一名GRS主旨演讲者将与GRC主席一起，通过辅导会议和在GRS会议期间与受训人员的持续互动提供支持和建议。GRC涵盖了从基础研究到临床应用的各种主题，拥有来自学术界和工业界的非常活跃的科学家组合，将主办约26至30场受邀演讲者的演讲。还将设想再进行10-14次较短的演讲，主要来自年轻科学家，将从提交的摘要中挑选出来。GRC还将包括4个海报会议。GRC计划安排两位主讲人，一位来自学术界，一位来自工业界，两人都是各自领域的国际公认专家。GRC计划的主题包括：A.抗体 与功能有关的结构和动力学；B.修改抗体多样性--它的产生和使用；C.抗体及其作用受体的功能；D.致病或保护性抗体的开发和机制；E.抗体生物工程中的独特治疗前景，特别是双特异性抗体的作用；F.选择抗体作为传递载体；以及G.应用抗体改变疾病的治疗挑战和机会。会议将报道在国际努力的前沿领域研究活动的最新未发表进展，该领域与临床治疗特别相关，因为许多进入临床或正在开发的新药都是基于免疫球蛋白或其衍生物的。在本系列前三次会议中创造性的学术界和产业界互动的悠久历史的基础上，这次GRC和GRS将为来自世界各地的学术和生物制药研究人员提供一个建立网络和打造新合作的理想机会。我们设想，这种想法的交叉授粉可能会产生新的治疗应用。此外，通过为年轻的研究人员提供机会介绍他们的研究，并与学术界和工业界更知名的科学家讨论他们的工作，这次会议将成为这一迅速崛起的领域未来科学领袖发展的重要跳板。

 DESCRIPTION (provided by the applicant): This application seeks partial support for the 2016 Gordon Research Conference (GRC) on Antibody Biology and Engineering, together with an accompanying Gordon Research Seminar (GRS) to be held on March 20 -28, 2016 at the Hotel Galvez in Galveston, Texas. This is the fourth GRC and the second GRS on this topic which is representative of a highly exciting and influential meeting in the community. The aim of this meeting is to provide in-depth coverage of important recent developments in the rapidly evolving field of antibody biology and engineering in an informal setting designed for maximal discussion and interaction. This field has broad implications for a wide variety of biologically an clinically important topics. The GRS will run immediately prior to the GRC and will provide seminar and poster sessions specifically for graduate students and post-doctoral scientists to allow them to present and discuss their research. A GRS keynote speaker, together with the GRC chairs, will offer support and advice through a mentorship session and continuous interactions with the trainees during the course of the GRS meeting. Spanning topics from basic research through to clinical applications and having a very dynamic mix of scientists from academia and industry, the GRC will host approximately 26-30 talks from invited speakers. A further 10-14 shorter talks that are primarily from young scientists that will be selected from submitted abstracts is also envisioned. The GRC will also incorporate 4 poster sessions. The GRC plans on two keynote speakers, 1 from academia and 1 from industry, both of whom are internationally recognized experts in their respective areas. The topics that are planned for the GRC include: A. Antibody structure and dynamics in relations to function; B. Modifying antibody diversity - it's generation and uses; C. The functionality of antibodies and the receptors through which they operate; D. Development and mechanisms of pathogenic or protective antibodies; E. Unique therapeutic vistas in antibody biology engineering and specifically the role of bispecific antibodies; F. Co-opting antibodies as a delivery vehicle, and; G. Therapeutic challenges and opportunities in the application of antibodies to modify disease. The conference will report the most recent unpublished advances in research activity at the leading edge of international efforts in a field that has particular relevance to clinical treatment in that many new drugs reaching the clinic or in development are based on immunoglobulins or their derivatives. Building on the long history of creative academia-industry interactions which have characterized the three previous meetings in this series, this GRC and GRS will provide an ideal opportunity for academic and bio-pharma researchers from around the world to network and forge new collaborations. We envision that novel therapeutic applications are likely to ensue from this cross pollination of ideas. Furthermore, by providing opportunities for younger researchers to present their studies and discuss their work with more established scientists in both academia and industry, this meeting will act as an important spring board for the development of future scientific leaders in this rapidly emerging field.