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Periodontal bacteria and Alzheimer?s disease

Periodontal bacteria and Alzheimer?s disease
牙周细菌和阿尔茨海默病
批准号:
9372139
负责人:
Kesavalu Naidu Lakshmyya
金额:
$19.06万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-08-01 至 2019-07-31
关键词:
Acute-Phase ProteinsAlzheimer&aposs DiseaseAmyloidAmyloid beta-ProteinAmyloid depositionAntibodiesAtherosclerosisAutoimmune ProcessAutopsyBacteriaBacterial TranslocationBiologyBrainBrain DiseasesCardiovascular systemCell surfaceCellsCerebrumChronicClinicalClinical ResearchCognitiveComplementComplement 3 ConvertaseComplement ActivationComplexDataDementiaDepositionDevelopmentDiseaseElderlyEnvironmental Risk FactorEtiologyGenesGeneticGenomic DNAGingivaGoalsHumanImmuneImmune responseImmune signalingImmune systemImmunoglobulin GImmunologic ReceptorsImpaired cognitionImpairmentIn VitroInfectionInfectious AgentInflammationInflammation MediatorsInflammatory ResponseInjectableInjection of therapeutic agentInnate Immune ResponseInnate Immune SystemInterleukin-1 betaLabelLaboratoriesLinkLipopolysaccharidesMediatingMembraneMethodsMicrobeModelingMono-SMusNatural ImmunityNerve DegenerationNeurodegenerative DisordersNeurogliaNeuronal InjuryOralOral cavityPathogenesisPathologicPathologyPatientsPeriodontal DiseasesPeriodontitisPeripheralPlasmaPlayPorphyromonasPorphyromonas gingivalisPre-Clinical ModelPredispositionProcessProteinsReportingResearchRheumatoid ArthritisRiskRisk FactorsRoleSeedsSenile PlaquesSerumStreptococcus gordoniiSystemic diseaseTNF geneTestingTissuesTooth Lossabeta accumulationabeta depositionamyloid formationantimicrobial peptidebrain tissueclinical predictorscytokineexperimental studygenetic risk factorimmune activationin vivointerestmicrobialmicrobiomemouse modelmultidisciplinaryneuroinflammationneuropathologyneurotoxicnon-dementedoral bacteriaoral microbiomeoral pathogenoral spirochetespathogenpreclinical studyresponsetau Proteins

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英文摘要
ABSTRACT Alzheimer's disease (AD) is a complex disease of unknown etiologic origin with both environmental and genetic risk factors, contributing to its onset. Systemic and brains local inflammation precedes neurodegenerative processes and predicts clinical onset of AD. Studies suggested that high burden of host inflammation may be responsible for amyloidogenic processes in AD, at least in preclinical models. Fibrillary amyloid β (Aβ) is central to the disease neuropathology, is neurotoxic, and has the capacity to inappropriately activate the innate immune responses including release of cytokines. However, susceptibility to peripheral microbial infections appears to increase during advancing age with the innate immune system becoming inadvertently activated as a disease promoting factor. Periodontal diseases (PD) are among the most common chronic infections of humans, characterized by loss of tooth supporting tissues and caused my complex bacteria underneath the gingiva. Numerous studies link PD associated chronic inflammation with increased risk of dementia, including AD. Plasma levels of antibodies to periodontal bacteria are significantly higher in AD patients compared to non- demented controls. A second study directly demonstrated the presence of multiple different oral bacterial species, causative of periodontal disease, in autopsy brains from AD subjects. We have shown Porphyromonas gingivalis lipopolysaccharide present in 4 out of 10 AD brain tissues and subsequently the innate immune activation as a critical risk factor for developing AD. Following chronic infection of mouse periodontal cavity with P. gingivalis, we could also detect the bacterial genomic DNA and viable bacteria in brains of infected mice. In spite of these findings, the mechanism by which periodontitis may be considered a risk factor for specific pathological hallmark proteins found in AD remains obscure. Despite interesting links between AD and PD and growing evidence that oral bacteria can regulate pathological hallmarks of AD, there is no in vivo study targeting a role for oral bacterium in the initiation of AD. The mechanistic link between chronic inflammation induced by oral bacteria and AD pathology is a high priority for exploration. We hypothesize that chronic systemic inflammation caused by the oral bacterium infection will seed higher Aβ plaque load, and NFT pathology in the TgCRND8 mice and enhance neuroinflammation and neuronal injury. The specific aims are to explore the role of oral bacteria P. gingivalis in regulating A pathology in TgCRND8 AD mouse model. The major objective is to determine the possible causal link between oral bacteria with AD hallmark pathology in vivo. Our long-term goal is to determine how an oral microbe P. gingivalis that can induce systemic effects can influence the development of amyloid and tau pathologies. This is a multidisciplinary project between laboratories that has expertise in periodontal disease research (Dr. Lakshmyya Kesavalu) and neuroinflammatory mechanisms of neurodegenerative diseases (Drs. Todd Golde and Yona Levites).
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Periodontal Pathogens and Cardiovascular Disease
  • 批准号:
    8431682
  • 项目类别:
  • 资助金额:
    $35.16万
  • 财政年份:
    2011
  • 负责人:
    Kesavalu Naidu Lakshmyya
  • 依托单位:
Periodontal Pathogens and Cardiovascular Disease
  • 批准号:
    8230484
  • 项目类别:
  • 资助金额:
    $36.63万
  • 财政年份:
    2011
  • 负责人:
    Kesavalu Naidu Lakshmyya
  • 依托单位:
Periodontal Pathogens and Cardiovascular Disease
  • 批准号:
    8618890
  • 项目类别:
  • 资助金额:
    $36.63万
  • 财政年份:
    2011
  • 负责人:
    Kesavalu Naidu Lakshmyya
  • 依托单位:
Periodontal Pathogens and Cardiovascular Disease
  • 批准号:
    8038546
  • 项目类别:
  • 资助金额:
    $36.63万
  • 财政年份:
    2011
  • 负责人:
    Kesavalu Naidu Lakshmyya
  • 依托单位: