Bacteriophage to prevent infection by antibiotic-resistant enterococci

噬菌体预防抗生素耐药肠球菌感染

基本信息

  • 批准号:
    9018963
  • 负责人:
  • 金额:
    $ 23.01万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-12-01 至 2017-11-30
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): New strategies and therapeutics to overcome the scourge of antibiotic-resistant bacterial infections are urgently needed. Enterococci are among the 3 most common causes of hospital-acquired infections, many of which are caused by enterococcal strains that are resistant to multiple antibiotics, including vancomycin. Systemic infections with antibiotic-resistant enterococci occur subsequent to colonization of the gastrointestinal tract, enabled by antibiotic therapy that leads to massive increases in abundance of drug-resistant enterococci. Thus, strategies to reduce or eliminate GI colonization by antibiotic-resistant enterococci before, during, or after antibiotic therapy represent innovativ approaches to reducing the incidence of antibiotic-resistant enterococcal infection and the spread of antibiotic-resistant isolates. We will use a new mouse model of GI colonization by enterococci with features that mimic the antibiotic-induced enterococcal expansion observed in humans to explore strategies to reduce enterococcal GI colonization. In particular, the research proposed here seeks to use lytic enterococcal bacteriophage to achieve reductions in enterococcal abundance in the mammalian GI tract before or during antibiotic therapy as a means of preventing infection by antibiotic-resistant enterococci.
 描述(由申请人提供):迫切需要新的策略和治疗方法来克服耐药性细菌感染的祸害。肠球菌是医院获得性感染的3种最常见原因之一,其中许多是由对多种抗生素(包括万古霉素)耐药的肠球菌菌株引起的。抗生素耐药肠球菌的全身感染发生在胃肠道定植之后,抗生素治疗导致耐药肠球菌丰度的大量增加。因此,在抗生素治疗之前、期间或之后减少或消除耐药肠球菌的GI定植的策略代表了减少耐药肠球菌感染的发生率和耐药分离株的传播的创新方法。我们将使用一种新的肠球菌GI定植小鼠模型,其特征模拟在人类中观察到的抗生素诱导的肠球菌扩增,以探索减少肠球菌GI定植的策略。特别是,本文提出的研究旨在使用裂解性肠球菌噬菌体来减少抗生素治疗前或治疗期间哺乳动物胃肠道中肠球菌的丰度,作为预防耐药性肠球菌感染的一种手段。

项目成果

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CHRISTOPHER J KRISTICH其他文献

CHRISTOPHER J KRISTICH的其他文献

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{{ truncateString('CHRISTOPHER J KRISTICH', 18)}}的其他基金

Host factors required for vancomycin resistance in enterococci
肠球菌万古霉素耐药所需的宿主因素
  • 批准号:
    10215113
  • 财政年份:
    2021
  • 资助金额:
    $ 23.01万
  • 项目类别:
Host factors required for vancomycin resistance in enterococci
肠球菌万古霉素耐药所需的宿主因素
  • 批准号:
    10339472
  • 财政年份:
    2021
  • 资助金额:
    $ 23.01万
  • 项目类别:
Role and regulation of peptidoglycan synthases in enterococcal antimicrobial resistance
肽聚糖合酶在肠球菌耐药性中的作用和调节
  • 批准号:
    10558661
  • 财政年份:
    2020
  • 资助金额:
    $ 23.01万
  • 项目类别:
Role and regulation of peptidoglycan synthases in enterococcal antimicrobial resistance
肽聚糖合酶在肠球菌耐药性中的作用和调节
  • 批准号:
    10348714
  • 财政年份:
    2020
  • 资助金额:
    $ 23.01万
  • 项目类别:
Conformation and functional dynamics of a bacterial PASTA kinase
细菌 PASTA 激酶的构象和功能动力学
  • 批准号:
    10526288
  • 财政年份:
    2020
  • 资助金额:
    $ 23.01万
  • 项目类别:
Conformation and functional dynamics of a bacterial PASTA kinase
细菌 PASTA 激酶的构象和功能动力学
  • 批准号:
    10302266
  • 财政年份:
    2020
  • 资助金额:
    $ 23.01万
  • 项目类别:
Analysis of PASTA kinase function in Enterococcus faecalis
粪肠球菌PASTA激酶功能分析
  • 批准号:
    9451474
  • 财政年份:
    2018
  • 资助金额:
    $ 23.01万
  • 项目类别:
Intrinsic cephalosporin resistance in enterococci
肠球菌的内在头孢菌素耐药性
  • 批准号:
    9419533
  • 财政年份:
    2018
  • 资助金额:
    $ 23.01万
  • 项目类别:
Role of a cell wall assembly factor in enterococcal antimicrobial resistance
细胞壁组装因子在肠球菌耐药性中的作用
  • 批准号:
    9225316
  • 财政年份:
    2017
  • 资助金额:
    $ 23.01万
  • 项目类别:
Genes of unknown function impacting antimicrobial resistance in enterococci
影响肠球菌耐药性的未知功能基因
  • 批准号:
    9370219
  • 财政年份:
    2017
  • 资助金额:
    $ 23.01万
  • 项目类别:

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