Biosynthesis via Synthetic Biology
Biosynthesis via Synthetic Biology
批准号:
9034600
负责人:
Huimin Zhao
金额:
$31.41万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
已结题
起止时间:
至 2018-03-31
关键词:
Acetyl Coenzyme AAcyltransferaseAnabolismAntibioticsAntimalarialsAreaBinding SitesCoenzyme ADNADNA MaintenanceDNA biosynthesisDevelopmentDirected Molecular EvolutionEngineeringEnzymesEquilibriumEscherichia coliEstersFosfomycinGene ExpressionGenesGoalsLibrariesMetabolicMethodsMethyltransferaseNatural ProductsParasitesPathway interactionsPhosphoenolpyruvatePhosphonic AcidsPlasmidsPlasmodium falciparumProductionPseudomonas syringaeResearchSaccharomyces cerevisiaeSeriesSourceStreptomycesStreptomyces lividansSubstrate SpecificityVariantanalogbasecombinatorialdesignexpression vectorgenetic elementgenome sequencingin vitro Assaymetabolic engineeringmetagenomemicrobialmicroorganismmutantnovelphosphonatepromoterreconstitutionscaffoldsynthetic biologyxylulose-5-phosphate
中文摘要
微生物产生无数的生物医学活性的天然产物或次级代谢产物,
和生物技术的重要性。然而,这些化合物的发现和可持续生产是非常困难的。
通常受限于我们操纵天然或非天然生物中的生物合成基因或簇的能力,
异源宿主为了克服天然产物生物合成研究领域的这一关键限制,
拟议研究的总体目标是开发用于发现的合成生物学方法,
表征和微生物中膦酸天然产物的工程化。具体来说,我们将
专注于FR-900098和磷霉素生物合成途径在异源宿主中的工程改造,
开发新的合成生物学方法,用于发现新的膦酸天然产物
基因组测序
英文摘要
Microorganisms produce a myriad array of natural products or secondary metabolites that are of biomedical
and biotechnological importance. However, the discovery and sustainable production of these compounds are
often limited by our capability to manipulate the biosynthetic genes or clusters in either the native or the
heterologous host. To overcome this key limitation in the natural product biosynthesis research area, the
overall goal of the proposed research is to develop synthetic biology approaches for discovery,
characterization, and engineering of phosphonic acid natural products in microorganisms. Specifically, we will
focus on the engineering of the FR-900098 and fosfomycin biosynthetic pathways in heterologous hosts and
development of new synthetic biology approaches for discovery of novel phosphonic acid natural products from
sequenced genomes.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Directed Evolution of Homing Endonucleases for Human Gene Therapy
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批准号:7472038
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项目类别:
-
资助金额:$18.65万
-
财政年份:2008
-
负责人:Huimin Zhao
-
依托单位:
Directed Evolution of Homing Endonucleases for Human Gene Therapy
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批准号:7617120
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项目类别:
-
资助金额:$22.5万
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财政年份:2008
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负责人:Huimin Zhao
-
依托单位:
Biosynthesis via Synthetic Biology
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批准号:8329255
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项目类别:
-
资助金额:$31.41万
-
财政年份:2007
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负责人:Huimin Zhao
-
依托单位:
PROTEIN AND METABOLIC ENGINEERING FOR BIOSYNTHESIS OF PHOSPHONIC ACID ANTIBIOTICS
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批准号:7249593
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项目类别:
-
资助金额:$40.41万
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财政年份:2007
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负责人:Huimin Zhao
-
依托单位:
DIRECTED EVOLUTION OF A THERMOSTABLE PHOSPHITE DEHYDROGENASE
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批准号:7357988
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项目类别:
-
资助金额:$3.17万
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财政年份:2006
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负责人:Huimin Zhao
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依托单位:
DIRECTED EVOLUTION OF A THERMOSTABLE PHOSPHITE DEHYDROGENASE
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批准号:7181251
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项目类别:
-
资助金额:$0.3万
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财政年份:2005
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负责人:Huimin Zhao
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依托单位:
STUDY OF BINDING CONSTANTS FOR WILD-TYPE & MUTANT PHOSPHITE DEHYDROGENASE
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批准号:7181217
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项目类别:
-
资助金额:$0.58万
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财政年份:2005
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负责人:Huimin Zhao
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依托单位:
STUDY OF BINDING CONSTANTS FOR WILD-TYPE & MUTANT PHOSPHITE DEHYDROGENASE
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批准号:6977648
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项目类别:
-
资助金额:$1.93万
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财政年份:2004
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负责人:Huimin Zhao
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依托单位:
PROTEIN AND METABOLIC ENGINEERING FOR BIOSYNTHESIS OF PHOSPHONIC ACID ANTIBIOTICS
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批准号:7843652
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项目类别:
-
资助金额:$37.43万
-
财政年份:--
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负责人:Huimin Zhao
-
依托单位:
PROTEIN AND METABOLIC ENGINEERING FOR BIOSYNTHESIS OF PHOSPHONIC ACID ANTIBIOTICS
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批准号:8053860
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项目类别:
-
资助金额:$37.96万
-
财政年份:--
-
负责人:Huimin Zhao
-
依托单位:
PROTEIN AND METABOLIC ENGINEERING FOR BIOSYNTHESIS OF PHOSPHONIC ACID ANTIBIOTICS
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批准号:7619570
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项目类别:
-
资助金额:$37.55万
-
财政年份:--
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负责人:Huimin Zhao
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依托单位:
Biosynthesis via Synthetic Biology
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批准号:8828226
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项目类别:
-
资助金额:$31.41万
-
财政年份:--
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负责人:Huimin Zhao
-
依托单位:
Biosynthesis via Synthetic Biology
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批准号:8457039
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项目类别:
-
资助金额:$30.31万
-
财政年份:--
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负责人:Huimin Zhao
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依托单位:
Biosynthesis via Synthetic Biology
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批准号:8634114
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项目类别:
-
资助金额:$31.41万
-
财政年份:--
-
负责人:Huimin Zhao
-
依托单位:
PROTEIN AND METABOLIC ENGINEERING FOR BIOSYNTHESIS OF PHOSPHONIC ACID ANTIBIOTICS
-
批准号:8259167
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项目类别:
-
资助金额:$37.34万
-
财政年份:--
-
负责人:Huimin Zhao
-
依托单位:
海外基金