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Pilot Study of Denosumab in BRCA1/2 Mutation Carriers Scheduled for Risk-Reducing Salpingo-Oopherectomy

Pilot Study of Denosumab in BRCA1/2 Mutation Carriers Scheduled for Risk-Reducing Salpingo-Oopherectomy
地诺单抗在 BRCA1/2 突变携带者中的初步研究计划用于降低风险的输卵管卵巢切除术
批准号：
9575770
负责人：
Powel Brown
金额：
$52.44万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
项目状态：
已结题
起止时间：
2017-09-21 至 2019-09-20
来源：
https://reporter.nih.gov/project-details/9575770
关键词：
BRCA1 geneContractorDoseEpithelial CellsMammalian OviductsMutationOperative Surgical ProceduresPilot ProjectsPremenopauseRiskSalpingo-OophorectomyScheduleWomanarmmutation carrier

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中文摘要
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英文摘要
The contractor will conduct a pre-surgical 2-arm pilot study to evaluate the effect of 3-4 monthly doses of denosumab on proliferation of fallopian tube epithelial cells in pre-menopausal women carrying a BRCA1/2 mutation.
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