Host-derived biomarker signatures to differentiate acute viral, bacterial, and fungal infection
Host-derived biomarker signatures to differentiate acute viral, bacterial, and fungal infection
批准号:
9373089
负责人:
Micah T. McClain
金额:
$19.88万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-07-18 至 2019-06-30
关键词:
AcuteAnti-Infective AgentsBacteremiaBacterial InfectionsBiological AssayBiological MarkersBlood specimenCandidaCandidiasisClinicClinicalCritical IllnessDataDevelopmentDiagnosisDiagnostic testsDiseaseEffector CellEnrollmentEtiologyFeverGene ExpressionGene Expression ProfileGene Expression ProfilingGenerationsGoalsHematologic NeoplasmsImmuneImmune responseImmunocompromised HostImmunosuppressionIndividualInfectionInfection ControlInfectious AgentMachine LearningMethodsMicrobiologyModalityMycosesOrgan TransplantationOrganismOutcomePathogen detectionPatient riskPatientsResistanceReverse Transcriptase Polymerase Chain ReactionRiskSamplingSocietiesSolidStatistical MethodsTestingTimeViralVirus DiseasesWorkaccurate diagnosisadjudicateantimicrobialbasecandidemiacohortevaluation/testinggenomic signaturehigh dimensionalityhigh risk populationhuman subjectimprovedimproved outcomeindividual patientlearning strategymigrationnovelnovel diagnosticspathogenperipheral bloodprototyperapid diagnosistherapy outcometranscriptome sequencing
中文摘要
工作说明
英文摘要
Statement of Work
There is an urgent need for improved diagnostic tests for the evaluation of the etiology of febrile
states, particularly in immunocompromised hosts. This project will develop host-based
biomarker signatures capable of identifying the presence and pathogen class of infections in
vulnerable immunocompromised human subjects, thus potentially allowing for earlier, more
directed (and thus more effective) therapy as well as reducing the need for potentially harmful
empiric anti-infective therapy. In this study we will a) perform high dimensional gene expression
analysis on existing samples of at-risk hosts with proven candidemia, viral infection, bacterial
infection, or noninfectious illness, b) develop peripheral blood-based gene expression
signatures of candidemia and c) generate a combined multinomial classifier capable of
differentiating four clinical states: viral infection, bacterial infection, fungal infection (candidemia)
and noninfectious illness. The enclosed work offers a true paradigm shift in the way febrile
illnesses in this high-risk population are diagnosed and managed.
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会议论文
Host-derived biomarker signatures for the diagnosis of acute rickettsial diseases
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批准号:10291785
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项目类别:
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资助金额:$0.0万
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财政年份:2019
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负责人:Micah T. McClain
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依托单位:
Host-derived biomarker signatures for the diagnosis of acute rickettsial diseases
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批准号:9860904
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项目类别:
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资助金额:$0.0万
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财政年份:2019
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负责人:Micah T. McClain
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依托单位:
Host-derived biomarker signatures for the diagnosis of acute rickettsial diseases
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批准号:10427237
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项目类别:
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资助金额:$0.0万
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财政年份:2019
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负责人:Micah T. McClain
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依托单位:
Genomic signatures for detection of upper respiratory viral infections
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批准号:8333080
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项目类别:
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资助金额:$0.0万
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财政年份:2012
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负责人:Micah T. McClain
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依托单位:
Genomic signatures for detection of upper respiratory viral infections
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批准号:8625188
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项目类别:
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资助金额:$0.0万
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财政年份:2012
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负责人:Micah T. McClain
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依托单位:
Venezuelan Equine Encephalitis Immunology and Vaccine Design
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批准号:7642741
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项目类别:
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资助金额:$8.46万
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财政年份:2009
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负责人:Micah T. McClain
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依托单位:
Venezuelan Equine Encephalitis Immunology and Vaccine Design
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批准号:7929480
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项目类别:
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资助金额:$12.56万
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财政年份:2009
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负责人:Micah T. McClain
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依托单位:
Venezuelan Equine Encephalitis Immunology and Vaccine Design
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批准号:8116627
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项目类别:
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资助金额:$12.56万
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财政年份:2009
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负责人:Micah T. McClain
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依托单位:
海外基金