Admin Core - Autophagy Modulators as Novel Broad-Spectrum Anti-Infective Agents

管理核心 - 自噬调节剂作为新型广谱抗感染剂

• 批准号: 10364722
• 负责人: HERBERT W VIRGIN
• 金额: $ 63.72万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-15 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10364722
• 关键词: Achievement; Address; Administrative Coordination; Advisory Committees; Animals; Anti-Infective Agents; Autophagocytosis; Award; Biology; Cell Line; Chemicals; Collaborations; Communication; Communication Programs; Complement; Contracts; Data; Data Analyses; Databases; Ensure; Evaluation; Fostering; Funding; Generations; Genes; Goals; Human Resources; Individual; Infrastructure; Institution; Laboratories; Leadership; Mediation; Methodology; National Institute of Allergy and Infectious Disease; Participant; Pathway interactions; Preparation; Process; Progress Reports; Quality Control; Reagent; Report (document); Reporting; Research; Research Activity; Research Project Grants; Resources; Series; Site; Stream; Teleconferences; Therapeutic; Time; Travel; United States National Institutes of Health; base; cohesion; collaborative environment; cost; data exchange; data sharing; experimental study; high throughput screening; meetings; member; novel; organizational structure; priority pathogen; programs; therapeutic development; therapeutic target

Project Summary – Administrative Core The Administrative Core will provide the requisite infrastructure to achieve the overall research objectives of the CETR. Effective scientific management and coordination by the Administrative Core will provide direction, oversight, and quality control for the research activities of each Project, and will maximize collaboration and exchange from all participating groups. Clear scientific leadership and direct communication by the Administrative Core will ensure optimal and transparent utilization of resources that promotes productive long- term relationships. The Administrative Core will promote data sharing, integration of projects, and communication, which will leverage the expertise of each member of the CETR to expedite discovery and achievement of the research goals. The Administrative Core will achieve several of these goals by providing a coherent stream of communication, which will begin by establishing monthly meetings between Program participants under the guidance of the Program Director. These meetings will be held through video teleconference and will promote data exchange, evaluation of progress and planning as it relates to the goals of the program and aims of individual projects. Each meeting will include discussion and analysis of results, goals and progress, as well as a forum for negotiation of key strategic decisions. The Administrative Core also will foster communication and organizational structure through preparation of financial reports and documents (e.g., progress reports) for the NIH. The Administrative Core will have specific financial responsibilities and obligations particularly as it relates to shared activities among CETR members. This will include costs associated with Scientific Advisory Committee travel and clerical/communication programs directly related to the CETR. Through these activities, the Administrative Core will ensure an interactive and collaborative environment, exchange of reagents and data, and foster a cohesive relationship among PIs of the CETR, which will enhance our direct goal of further developing novel autophagy-directed anti-infectives against NIAID priority pathogens.

项目摘要-行政核心 行政核心将提供必要的基础设施，以实现本组织的总体研究目标。 CETR。行政核心的有效科学管理和协调将提供方向， 监督和质量控制每个项目的研究活动，并将最大限度地合作， 所有参与团体的交流。明确的科学领导和直接沟通 行政核心将确保以最佳和透明的方式利用资源，促进长期的生产力， 长期关系。行政核心将促进数据共享、项目整合， 通信，这将利用CETR每个成员的专业知识，以加快发现和 实现研究目标。行政核心将通过提供一个 连贯的沟通流，开始时，将在各计划之间建立每月会议 参与者在项目经理的指导下。这些会议将通过视频进行 将促进数据交流、进展评价和规划，因为这与实现 个别项目的计划和目标。每次会议都将讨论和分析结果、目标 以及一个就关键战略决策进行谈判的论坛。行政核心还将 通过编制财务报告和文件促进沟通和组织结构（例如， 进度报告）。行政核心将承担具体的财务责任和义务 特别是因为它涉及到CETR成员之间的共同活动。这将包括与以下方面有关的费用： 科学咨询委员会旅行和文书/通信计划直接相关的CETR。通过 这些活动，行政核心将确保互动和协作的环境，交流， 试剂和数据，并促进CETR的PI之间的凝聚力关系，这将提高我们的直接 目标是进一步开发针对NIAID优先病原体的新型自噬导向的抗感染药物。