Admin Core - Autophagy Modulators as Novel Broad-Spectrum Anti-Infective Agents

项目摘要 – 行政核心 行政核心将提供必要的基础设施，以实现该中心的总体研究目标 CETR。行政核心的有效科学管理和协调将提供方向， 对每个项目的研究活动进行监督和质量控制，并将最大限度地合作和 各参赛团体进行交流。明确的科学领导和直接沟通 行政核心将确保资源的最佳和透明利用，促进生产性长期 术语关系。行政核心将促进数据共享、项目集成和 沟通，这将利用 CETR 每个成员的专业知识来加快发现和 研究目标的实现。行政核心将通过提供 连贯的沟通流程，首先是在计划之间建立每月一次的会议 参与者在项目总监的指导下。这些会议将通过视频举行 电话会议，并将促进与目标相关的数据交换、进展评估和规划 各个项目的计划和目标。每次会议将包括对结果、目标的讨论和分析 和进展，以及关键战略决策谈判的论坛。行政核心还将 通过准备财务报告和文件（例如， NIH 的进展报告）。行政核心将承担具体的财务责任和义务 特别是因为它涉及 CETR 成员之间的共同活动。这将包括与以下相关的成本 科学咨询委员会与 CETR 直接相关的旅行和文书/通讯计划。通过 在这些活动中，行政核心将确保一个互动和协作的环境，交流 试剂和数据，并在 CETR 的 PI 之间建立有凝聚力的关系，这将增强我们的直接 进一步开发针对 NIAID 优先病原体的新型自噬导向抗感染药物的目标。

Project Summary – Administrative Core The Administrative Core will provide the requisite infrastructure to achieve the overall research objectives of the CETR. Effective scientific management and coordination by the Administrative Core will provide direction, oversight, and quality control for the research activities of each Project, and will maximize collaboration and exchange from all participating groups. Clear scientific leadership and direct communication by the Administrative Core will ensure optimal and transparent utilization of resources that promotes productive long- term relationships. The Administrative Core will promote data sharing, integration of projects, and communication, which will leverage the expertise of each member of the CETR to expedite discovery and achievement of the research goals. The Administrative Core will achieve several of these goals by providing a coherent stream of communication, which will begin by establishing monthly meetings between Program participants under the guidance of the Program Director. These meetings will be held through video teleconference and will promote data exchange, evaluation of progress and planning as it relates to the goals of the program and aims of individual projects. Each meeting will include discussion and analysis of results, goals and progress, as well as a forum for negotiation of key strategic decisions. The Administrative Core also will foster communication and organizational structure through preparation of financial reports and documents (e.g., progress reports) for the NIH. The Administrative Core will have specific financial responsibilities and obligations particularly as it relates to shared activities among CETR members. This will include costs associated with Scientific Advisory Committee travel and clerical/communication programs directly related to the CETR. Through these activities, the Administrative Core will ensure an interactive and collaborative environment, exchange of reagents and data, and foster a cohesive relationship among PIs of the CETR, which will enhance our direct goal of further developing novel autophagy-directed anti-infectives against NIAID priority pathogens.