Mentoring Multidisciplinary Patient-Oriented Research in Engagement in HIV Care

项目摘要 我寻求K24奖的支持，以建立一个以患者为导向的研究指导计划， 加强全球艾滋病毒治疗的参与。目前，我领导着强大的研究活动， 由多种机制支持（包括NIH R 01 & U 01、HRSA和盖茨基金会） 每年有超过150万美元的直接资助。我在美国领导工作， 四个非洲国家（乌干达、肯尼亚、津巴布韦和赞比亚），其中一些国家在既定的 科学网络（例如，评估艾滋病的国际流行病学数据库）。这 不断增长的研究组合为指导学员创造了大量机会，包括 由T32和D43机制支持的博士后研究员、博士前学生以及 国际伙伴组织（例如，坎帕拉的Makerere大学）。支持下 从K24奖，我会提供一个全面的，但适应性强的指导蓝图， 重点是指导调查人员跨越两个关键门槛：首先，研究人员要建立一个 通过获得K23职业发展奖，第二，维持 通过随后的R 01级资助的研究生涯。我的导师模式是基于 个人会议以及一个导师团队的集会， 专业和个人需要。此外，在加州大学旧金山分校，我计划整合拟议的 指导与现有资源的培训由UCSF CTSI和中心的支持， 艾滋病研究。在加州大学旧金山分校之外，我将把学生介绍到蓬勃发展的研究财团 我在其中活动（例如，以及公共卫生实施 组织（例如，赞比亚传染病研究中心）， 多站点数据和发展独立的科学项目和专业关系。到 为了改善我的指导，我将在加州大学旧金山分校成立一个高级教师咨询委员会， 使用基于证据的成功指标对我的指导进行反馈和评估。目前， 我每年都会收到八到十个导师的请求，但我只能接受两个 因为我的努力完全由项目具体的研究角色，临床职责和 行政义务。来自K24的支持将允许我接受多达8名学员 一年这将包括担任1名博士后研究员的主要导师， 指导2-3名研究员和其他博士前居民和学生。K24将 请允许我把更多的时间投入到与博士后的最密集的导师关系中， 竞争K23职业发展奖的研究员以及那些寻求从 K23至R 01级资金和完全的科学独立性。

Project Summary I seek support from a K24 Award to build a mentoring program in patient oriented research to enhance engagement in HIV treatment globally. At present, I lead robust research activities supported by diverse mechanisms (including NIH R01 & U01, HRSA, and Gates Foundation) with over 1.5 million dollars a year of direct funding. I am leading work in the US as well as four African countries (Uganda, Kenya, Zimbabwe and Zambia), some within established scientific networks (e.g., International Epidemiologic Databases to Evaluate AIDS). This growing research portfolio has created abundant opportunities to mentor trainees, including post-doctoral fellows supported by T32 and D43 mechanisms, pre-doctoral students, and those from international partner organizations (e.g., Makerere University in Kampala). With support from a K24 Award, I would offer a comprehensive but adaptable blueprint for mentorship, with a focus on guiding investigators across two critical thresholds: first, for fellows establishing a research career through obtaining a K23 Career Development Award, and second, sustaining a research career through subsequent R01 level funding. My mentorship model is based both on individual meetings as well as assembly of a team of mentors who can meet diverse technical, professional and personal needs. In addition, within UCSF, I plan to integrate the proposed mentoring with existing resources for training supported by the UCSF CTSI and the Center for AIDS Research. Outside of UCSF, I will introduce mentees into flourishing research consortia in which I am active (e.g., IeDEA and CNICS) as well as into public health implementing organizations (e.g., Center for Infectious Disease Research in Zambia) where they can access multi-site data and develop independent scientific projects and professional relationships. To improve my mentoring, I will form an advisory committee of senior faculty at UCSF who will offer feedback and evaluation on my mentoring using evidence-based metrics of success. At present, I receive eight to ten requests for mentorship each year and have only been able to accept two to three because my effort is fully taken by project specific research roles, clinical duties and administrative obligations. Support from a K24 will allow me to accept up to eight total mentees a year. This would include serving as primary mentor to 1 post-doctoral fellow and secondary mentor to 2-3 fellows and other pre-doctoral residents and students. In particular, a K24 will allow me to dedicate more time to the most intensive mentorship relationships with post doctoral fellows competing for K23 Career Development Awards as well those seeking transition from K23 to R01 level funding and full scientific independence.