Mentoring Multidisciplinary Patient-Oriented Research in Engagement in HIV Care

项目摘要 我寻求K24奖的支持，以建立以患者为导向的研究指导计划，以 加强全球对艾滋病毒治疗的参与。目前，我领导着强有力的研究活动 得到不同机制的支持(包括NIH R01和U01、HRSA和盖茨基金会) 每年有超过150万美元的直接资金。我在美国领导工作，也在领导 四个非洲国家(乌干达、肯尼亚、津巴布韦和赞比亚)，其中一些在建立 科学网络(例如，评估艾滋病的国际流行病学数据库)。这 不断增长的研究组合创造了大量指导学员的机会，包括 由T32和D43机制支持的博士后研究员、博士后学生和 来自国际伙伴组织(如坎帕拉的Makerere大学)。有了支持 在K24奖项中，我将提供一份全面但可适应的导师蓝图，其中包括 重点引导调查人员跨过两个关键门槛：第一，对于研究员建立 通过获得K23职业发展奖来从事研究工作；第二，保持 通过随后的R01级资助进行研究。我的良师益友模式既基于 个别会议以及指导团队的集合，他们可以满足不同的技术、 职业和个人需求。此外，在加州大学旧金山分校，我计划将拟议的 利用加州大学旧金山分校CTSI和中心支持的现有培训资源进行指导 艾滋病研究。在加州大学旧金山分校之外，我将向学员介绍蓬勃发展的研究联盟。 我积极参与其中(例如，IeDEA和CNIC)以及公共卫生实施 他们可以访问的组织(例如赞比亚传染病研究中心) 多站点数据和发展独立的科学项目和专业关系。至 改善我的指导，我将成立一个由加州大学旧金山分校高级教员组成的顾问委员会，他们将提供 使用基于证据的成功标准对我的指导进行反馈和评估。目前， 我每年都会收到八到十份辅导申请，但我只接受了两份 到三个，因为我的努力完全被项目特定的研究角色、临床职责和 行政义务。来自K24的支持将允许我接受最多8名学员 一年。这将包括担任1名博士后研究员和中学博士后的主要导师 指导2-3名研究员和其他博士后住院医生和学生。特别是，一架K24将 请允许我把更多的时间花在与博士后最紧密的指导关系上 角逐K23职业发展奖的研究员以及寻求从 K23到R01级别的资助和完全的科学独立性。

Project Summary I seek support from a K24 Award to build a mentoring program in patient oriented research to enhance engagement in HIV treatment globally. At present, I lead robust research activities supported by diverse mechanisms (including NIH R01 & U01, HRSA, and Gates Foundation) with over 1.5 million dollars a year of direct funding. I am leading work in the US as well as four African countries (Uganda, Kenya, Zimbabwe and Zambia), some within established scientific networks (e.g., International Epidemiologic Databases to Evaluate AIDS). This growing research portfolio has created abundant opportunities to mentor trainees, including post-doctoral fellows supported by T32 and D43 mechanisms, pre-doctoral students, and those from international partner organizations (e.g., Makerere University in Kampala). With support from a K24 Award, I would offer a comprehensive but adaptable blueprint for mentorship, with a focus on guiding investigators across two critical thresholds: first, for fellows establishing a research career through obtaining a K23 Career Development Award, and second, sustaining a research career through subsequent R01 level funding. My mentorship model is based both on individual meetings as well as assembly of a team of mentors who can meet diverse technical, professional and personal needs. In addition, within UCSF, I plan to integrate the proposed mentoring with existing resources for training supported by the UCSF CTSI and the Center for AIDS Research. Outside of UCSF, I will introduce mentees into flourishing research consortia in which I am active (e.g., IeDEA and CNICS) as well as into public health implementing organizations (e.g., Center for Infectious Disease Research in Zambia) where they can access multi-site data and develop independent scientific projects and professional relationships. To improve my mentoring, I will form an advisory committee of senior faculty at UCSF who will offer feedback and evaluation on my mentoring using evidence-based metrics of success. At present, I receive eight to ten requests for mentorship each year and have only been able to accept two to three because my effort is fully taken by project specific research roles, clinical duties and administrative obligations. Support from a K24 will allow me to accept up to eight total mentees a year. This would include serving as primary mentor to 1 post-doctoral fellow and secondary mentor to 2-3 fellows and other pre-doctoral residents and students. In particular, a K24 will allow me to dedicate more time to the most intensive mentorship relationships with post doctoral fellows competing for K23 Career Development Awards as well those seeking transition from K23 to R01 level funding and full scientific independence.