Mid Southern Primary Care Networks Node

 产品说明：国家药物滥用治疗临床试验网络（CTN）寻求扩大其范围，包括基于初级保健实践的研究网络（PBRN），为有兴趣参与研究项目和使用电子健康记录（EHR）进行研究的患者人群和临床医生提供访问。我们建议建立一个中南初级保健网络节点。该跨学科团队由PI Dr. Wu（杜克初级保健3项CTN研究的PI）和Co-PI Dr. Dolor（杜克初级保健研究联盟主任，杜克PCRC）领导。杜克PCRC是一个初级保健临床医生网络，他们在临床研究中进行合作，包括北卡罗来纳州（NC）皮埃蒙特地区8个县的30多个实践，包括城市和农村地区。自1997年以来，杜克PCRC已从>100项试验中招募了>8000名受试者。杜克PCRC是医疗保健研究和质量机构（AHRQ）的初级保健PBRN注册网络。杜克PCRC是NC网络联盟（NCNC）的成员网络，NCNC是一个由8个基于实践的研究网络组成的元网络（369个实践，>2100个供应商）。我们的合作伙伴包括NCNC、梅克伦堡地区初级保健研究伙伴关系（MAPPR）、大型南卡罗来纳州医疗保健系统、北卡罗来纳州儿童健康研究网络（NC-CHRN）、北卡罗来纳州多地点青少年健康研究联盟（NC-MARCH）和PCOR支持的中南临床数据研究网络（田纳西州）。Dolor博士也是Bravewell中西医结合研究网络（BraveNet）协调中心的PI-一个由14个中西医结合中心组成的PBRN，通过初级保健研究评估综合方法。成瘾和初级保健之间的这种多学科合作关系确保了我们成功地吸引患者，提供者，诊所管理人员和基于实践的研究人员进行多站点项目并支持CTN任务。我们继续利用我们基于初级保健的纵向默多克登记和生物储存研究的丰富资源（包括健康信息学专家团队）作为我们正在进行的研究基础设施，以促进招募和合作。杜克转化医学研究所（DTMI）测量了解Cabarrus/坎纳波利斯（默多克）疾病的重新分类研究是一项大规模的研究计划，旨在通过生物标志物发现、环境因素的阐明和疾病的分子重新分类，促进向预测性、预防性和个性化医学的过渡。Dr. Robert Califf - DTMI主任;默多克研究、NIH协作实验室协调中心和杜克CTSA的PI;以及PCORNet协调中心的联合主任-担任实物Co-I和科学顾问。共有11家医疗机构参与了默多克研究，这些研究增加了我们接触不同患者和提供者人群的机会。我们使用多学科团队科学的方法，通过最大限度地利用完善的基础设施，建立一个中南部初级保健网络节点。

 DESCRIPTION: Mid Southern Primary Care Networks Node of the NIDA Clinical Trials Network The National Drug Abuse Treatment Clinical Trials Network (CTN) seeks to expand its scope to include primary care practice-based research networks (PBRNs) that offer access to patient populations and clinicians who are interested in engaging in research projects and using Electronic Health Records (EHRs) for research. We propose to establish a Mid Southern Primary Care Networks Node. This interdisciplinary team is led by PI Dr. Wu (Duke PI of 3 CTN studies in primary care) and Co-PI Dr. Dolor (Director of Duke Primary Care Research Consortium, Duke PCRC). Duke PCRC is a network of primary care clinicians who collaborate in clinical research studies, including >30 practices in 8 counties of the Piedmont area of North Carolina (NC), including urban and rural areas. Since 1997, Duke PCRC has enrolled >8000 subjects from >100 trials. Duke PCRC is a registered network in the Agency for Healthcare Research and Quality (AHRQ) for primary care PBRNs. Duke PCRC is a member network within NC Network Consortium (NCNC), a meta-network composed of 8 practice-based research networks in NC (369 practices, >2100 providers). Our partners include NCNC, Mecklenburg Area Partnership for Primary Care Research (MAPPR), large Carolinas HealthCare System, NC Child Health Research Network (NC-CHRN), NC Multi-Site Adolescent Research Consortium for Health (NC- MARCH), and a PCORI-supported Mid-South Clinical Data Research Network (Tennessee). Dr. Dolor also is PI of the Coordinating Center for the Bravewell Integrative Medicine Research Network (BraveNet) - a PBRN of 14 integrative medicine centers that evaluate integrative approaches through research in primary care. This multidisciplinary partnership between addiction and primary care ensures our successful engagement of patients, providers, clinic administrators, and practice-based researchers to conduct multisite projects and support CTN missions. We continue to leverage a wealth of resources (including a team of health informatics experts) from our primary care based longitudinal MURDOCK Registry and Biorepository Study as our ongoing research infrastructure to facilitate recruitment and collaboration. Duke Translational Medicine Institute (DTMI) Measurement to Understand the Reclassification of Disease of Cabarrus/Kannapolis (MURDOCK) study is a large-scale research initiative designed to foster the transition to predictive, preventive, personalized medicine through biomarker discovery, elucidation of environmental factors, and the molecular reclassification of diseases. Dr. Robert Califf - DTMI Director; PI of the MURDOCK study, the NIH Collaboratory Coordinating Center, and Duke CTSA; and co-Director of the PCORNet Coordinating Center - serve as an in-kind Co-I and Scientific Advisor. A total of 11 medical sites are affiliated with the MURDOCK study that enhance our access to diverse patient and provider populations. We use a multidisciplinary team-science approach to establish a Mid Southern Primary Care Networks Node by maximizing use of well-established infrastructures.