COBRE for Perinatal Biology

COBRE 围产期生物学

• 批准号: 9270050
• 负责人: SUNIL K SHAW
• 金额: $ 81.29万
• 依托单位: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-18 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9270050
• 关键词: 1-Phosphatidylinositol 3-Kinase; Adolescent; Adult; Aging; Alzheimer' s Disease; Antibodies; Antigens; Award; Biology; Cardiac; Cardiac Myocytes; Cardiopulmonary; Centers of Research Excellence; Child; Collaborations; Core Facility; Creativeness; Development; Diagnosis; Disease; Elements; Embryonic Development; Environment; Equipment; Erythrocytes; Extramural Activities; Faculty; Fostering; Goals; Grant; Heart; Hospitals; Human; Immune response; Infant; Interdisciplinary Study; Joints; Leadership; Life; Malaria; Malaria Vaccines; Malignant Neoplasms; Mentors; Newborn Infant; Parasites; Pathogenesis; Pathway interactions; Patients; Perinatal; Phase; Pre-Eclampsia; Prealbumin; Premature Birth; Proteins; Proteomics; Regulatory Pathway; Reproductive Biology; Research; Research Personnel; Resistance; Resources; Role; Science; Scientist; Signal Transduction; Stem cells; Technology; Vaccinated; Vaccines; Woman; Work; adult stem cell; base; career; cohort; fetal; in vitro Bioassay; injured; insight; instrumentation; interdisciplinary collaboration; malaria infection; mouse model; novel; novel therapeutics; operation; programs; public health relevance; repaired; restoration; success

 DESCRIPTION (provided by applicant): The scientific aims of our COBRE have been to increase our understanding of reproductive biology and cardiopulmonary development, to enhance our understanding of perinatal diseases, like preeclampsia and preterm birth, and to develop new opportunities for novel therapeutic strategies. Our research focus during Phase I and Phase II has been driven by recognition that the fundamental mechanisms that regulate embryonic development, cancer, and aging are overlapping. The success of our projects has been enhanced by the common view that looking through this "prism of development" provides unique experimental leverage and testable hypotheses for how regulatory pathways are governed later in life. The programmatic aims of the COBRE have been to create a Center for Perinatal Biology providing scientific and career mentoring to junior faculty within an environment fostering creativity and transdisciplinary collaboration. During Phase III of the COBRE for Perinatal Biology, our objectives will be: 1) continued support of COBRE-related activities; 2) transition the Center to sustainability; and 3) enhance perinatal and developmental research at Women & Infants Hospital. Resources for the Research Core programs will be used to upgrade existing instrumentation to enhance our research sophistication. The Pilot Grants Program associated with the Phase-III COBRE will be used to stimulate collaborative research efforts that will contribute to joint applications among the investigators and sustaining resources for the Core Facilities. The Specific Aims we have identified to accomplish these goals are: Specific Aim 1: Provide Overall Leadership supporting the Administrative Core's ability to manage the operations and to transition the COBRE for Perinatal Biology into a sustainable Center for Perinatal Biology toward long-term sustainability. Specific Aim 2: Develop a sustainable, state-of-the-art Research Core that maximizes the use and impact of contemporary approaches, equipment, and technology for Perinatal Research. Specific Aim 3: Utilize Pilot Grants Program resources to catalyze multi-disciplinary research leading to additional extramural awards in Perinatal Research.

 描述（由申请人提供）：我们的COBRE的科学目标是增加我们对生殖生物学和心肺发育的理解，增强我们对围产期疾病（如先兆子痫和早产）的理解，并为新的治疗策略开发新的机会。我们在第一阶段和第二阶段的研究重点是认识到调节胚胎发育，癌症和衰老的基本机制是重叠的。我们项目的成功得到了普遍的看法，即通过这个“发展棱镜”来观察，为以后的生活中如何管理调控途径提供了独特的实验杠杆和可检验的假设。COBRE的计划目标是建立一个围产期生物学中心，为年轻教师提供科学和职业指导，以培养创造力和跨学科合作。在围产期生物学COBRE的第三阶段，我们的目标将是：1）继续支持COBRE相关活动; 2）将中心过渡到可持续发展; 3）加强妇女和婴儿医院的围产期和发育研究。研究核心计划的资源将用于升级现有仪器，以提高我们的研究复杂性。与第三阶段COBRE相关的试点赠款计划将用于促进合作研究工作，这将有助于研究人员之间的联合申请和维持资源 核心设施。具体目标1：提供全面领导，支持行政核心管理运营的能力，并将围产期生物学COBRE转变为可持续的围产期生物学中心，以实现长期可持续性。具体目标二：开发一个可持续的，国家的最先进的研究核心，最大限度地利用和当代方法，设备和技术的影响围产期研究。具体目标3：利用试点赠款计划的资源，以促进多学科的研究，导致额外的围产期研究校外奖项。