Core B: Repository Core

核心B：存储库核心 项目摘要/摘要 为了促进利用创新的分子、细胞和动物模型系统来检查 MHTT与TIRE网络之间的相互作用以及TICE试剂调节对 高清病理，我们将建立一个核心储存库。存储库是多个研究人员的关键资源 为NIH项目启动并建立了检查神经退行性疾病和 精神错乱。通常，存储库存储各种试剂、协议和其他关键数据并对其进行编目 总体意图旨在迅速促进资源共享，以开发新的疗法。 为所述建议书中的工作建立存储库核心是计划项目拨款的重要部分 以支持项目目标。资料库核心将通过以下方式支持整个项目的研究 标准化的优质多肽、载体、细胞和组织试剂的生产，试剂的存档和 协议和分发到项目站点。具体目标是：1)建立沉积的物理核心 TICE和HTT试剂和程序特定网络，2)核心的协调利用

CORE B: REPOSITORY CORE PROJECT SUMMARY/ABSTRACT In order to facilitate the goal of utilizing innovative molecular, cellular and animal model systems to examine the interactions between mHTT and the TRiC network and to examine TRiC reagent modulations impact on HD pathology, we will establish a repository core. Repositories are a critical resource for multi-researcher initiated studies and have been established for NIH programs examining neurodegenerative diseases and disorders. In general, repositories store and catalogue various reagents, protocols and other critical data with the overall intention aimed at rapidly facilitating sharing resources for the development of new therapies. Establishing a repository core for the work in the described proposal is a vital part of the Program Project Grant to support the project goals. The Repository Core will support research throughout the projects by facilitating production of standardized high quality peptide, vector, cell and tissue reagents, archiving of reagents and protocols and distribution to project sites. Specific aims are to; 1) Establish a physical core for deposition of TRiC and HTT reagents and a Program specific network, 2) Coordinate utilization of the Core