Comprehensive Motion-Robust Pediatric MR Imaging Using Radial Acquisitions

使用径向采集的综合运动鲁棒性儿科 MR 成像

• 批准号: 9185973
• 负责人: Kai Tobias Block
• 金额: $ 38.85万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9185973
• 关键词: Abdomen; Adult; Anesthesia procedures; Awareness; Benchmarking; Blinded; Chest; Childhood; Clinical; Clinical Research; Complement; Complex; Data; Detection; Development; Diagnostic; Diagnostic Imaging; Elderly; FDA approved; Fatty acid glycerol esters; General Anesthesia; Image; Imaging Techniques; Impairment; Institution; Kidney; Lesion; Logistics; Magnetic Resonance Imaging; Medical; Methods; Modeling; Morphologic artifacts; Motion; Patients; Phase; Protocols documentation; Radial; Reader; Respiration; Risk; Safety; Sampling; Scanning; Scheme; Sedation procedure; T2 weighted imaging; Techniques; Testing; Time; Translating; Tuberous Sclerosis; Water; Work; base; clinical application; clinical imaging; clinical practice; contrast imaging; diagnostic accuracy; high resolution imaging; imaging approach; improved; novel; pediatric patients; prevent; public health relevance; radiation effect; reconstruction; saturated fat; tuberous sclerosis patients

DESCRIPTION (provided by applicant): There is growing awareness of the detrimental effect of radiation associated with diagnostic imaging in pediatric patients. Although in many cases abdominal MRI can serve as a viable alternative to CT, it is underutilized in clinical practice due to a) high sensitivity to motion artifacts, b) need to perform these exams under general anesthesia or deep sedation to obtain acceptable diagnostic image quality, and c) limitations in the diagnostic accuracy, as data cannot be acquired during suspended respiration in patients who are under sedation. In the proposed project, we will develop and evaluate novel motion-robust MRI techniques based on radial k-space acquisition and advanced non-linear reconstruction to overcome these limitations. The developments will complement our existing radial techniques for motion-robust MRI, which provide only fat- saturated T1-weighted contrast and, thus, cannot be utilized for comprehensive diagnostic exams so far. The technical developments include a new fat/water-separation technique for radial 3D multi-gradient-echo acquisitions, which can be used to assess the fat content of lesions and to resolve artifacts currently seen in T1-weighted radial acquisitions with spectral fat saturation. To obtain T2-weighted image contrast, a robust radial 3D TSE sequence will be developed and combined with a tailored compressed-sensing reconstruction to achieve clinically acceptable scan times. In addition, a novel time-efficient image-stabilization technique will be developed based on k-space consistency assessment and adaptive data rescanning. It will be integrated into all our radial sequences to prevent data inconsistencies from bulk patient motion. All developed techniques will be evaluated, first, in sedated pediatric patients with Tuberous Sclerosis and compared to the clinical-imaging standard. The improvement in image quality will be assessed in blinded-reader studies and by quantitatively estimating the lesion detection rate. The techniques will then be used to implement a full-radial diagnostic exam strategy for pediatric abdominal MRI, which will enable motion-robust examination of pediatric patients without the use of deep sedation or general anesthesia. The sedation-free imaging approach will be evaluated in patients with Tuberous Sclerosis and benchmarked in terms of image quality, detection accuracy, and exam time against the clinical standard for pediatric abdominal MRI performed under general anesthesia or with deep sedation. This new simplified exam strategy promises not only to change the way diagnostic body MRI is done in pediatric patients but it will also impact clinical imaging of elderly and sick patients who cannot adequately suspend respiration.

描述（由申请人提供）：越来越多的人意识到与儿科患者诊断成像相关的辐射的有害影响。虽然在许多情况下，腹部MRI可以作为CT的可行替代方案，但由于