Biology

肥胖、高血压、血脂异常、糖尿病和吸烟在年轻成年人中的估计流行率表明，在一个通常以无慢性疾病负担为特征的年龄组中，心血管疾病（CVD）的风险高于预期。尽管有这样的建议，在生命的第四个十年中CVD风险的变化和表现还没有在一个大的，当代的，或全国代表性的研究中进行过检查。因此，计划项目研究人员建议将生物数据和标本的收集纳入国家青少年健康纵向研究（Add Health）的第五波。生物学数据对于确定多种慢性疾病的变化和发病将是重要的。拟议工作的重点是收集人体测量、心血管、代谢、炎症、肾脏和药物流行病学指标。这些衡量标准是根据对40岁以下慢性病发病率和死亡率的主要原因、特定生物过程在其因果关系中的作用以及既定衡量标准描述这些过程的能力的科学知识选择的。生物学核心将监督Add Health队列生物标本的采集、测定和存档要求。核心工作人员将清理、记录和解释检测结果，并将与传播核心合作，使这些数据可用于计划项目子项目和更大的研究社区。该中心有多个目标：（1）确定、评价和建议创新、适当和可行的生物措施;（2）制定生物标本采集规程，并指导采访人员进行标本采集培训;（3）通过与实地承包商和实验室的互动，监测采集标本的质量;（4）监测从实验室收到的数据的质量，并监督生物数据的记录;（5）在项目研究者将生物数据纳入其子项目分析时，向项目研究者提供咨询和建议;（6）就AddHealth生物数据的解释和使用向外部研究人员咨询;和（7）提供科学领导和监督Add Health研究议程，将生物学纳入研究设计，目标，通过促进研究思路的发展和参与使用生物标本和数据的拟议研究的审查过程来进行分析。生物学核心由两名研究人员领导，他们在大型队列研究中收集生物标本方面拥有丰富的经验。该核心将与其他核心广泛合作，并将为子项目提供数据、协作和咨询。核心的拟议活动将有助于检查美国实现多种预防工作的积极目标的能力，包括到2020年所有美国人的心血管健康改善20%，心血管疾病死亡相应减少20%。这种审查将为各级利益攸关方及时提供可采取行动的知识。

The estimated prevalence of obesity, hypertension, dyslipidemia, diabetes and smoking in young adulthood suggests a higher than anticipated risk of cardiovascular disease (CVD) in an age group often characterized as unburdened by chronic illness. Despite that suggestion, changes in and manifestations of CVD risk through the fourth decade of life have not been examined in a large, contemporary, or nationally representative study of young U.S. adults at the forefront of the obesity epidemic. Therefore, Program Project investigators propose to include collection of biological data and specimens in Wave V of the National Longitudinal Study of Adolescent Health (Add Health). The biological data will be important in identifying change in and onset of multiple chronic diseases. The focus of the proposed effort is collection of anthropometric, cardiovascular, metabolic, inflammatory, renal and pharmacoepidemiologic measures. These measures were selected based on scientific knowledge of the leading causes of chronic disease morbidity and mortality through age 40, the role of specific biological processes in their causation and consequences, as well as the ability of established measures to characterize these processes. The Biology Core will oversee the collection, assay, and archival requirements of biological specimens from the Add Health cohort. Core staff will clean, document, and interpret assay results and will work with the Dissemination Core to make these data available to the Program Project subprojects and to the larger research community. The Core has multiple objectives: (1) to identify, evaluate, and recommend innovative, appropriate and feasible biological measures; (2) to develop protocols for the collection of biological specimens and guide interviewer training in specimen collection; (3) to monitor the quality of specimens collected through interaction with field contractors and laboratories; (4) to monitor quality of data received from laboratories and oversee documentation of biological data; (5) to provide consultation and advice to Program Investigators as they integrate biological data in their subproject analyses; (6) to consult with external researchers on interpretation and use of Add Health biological data; and (7) to provide scientific leadership and oversight of Add Health research agendas incorporating biology in study design, objectives, and analysis by contributing to the development of research ideas and participating in a review process of proposed research using biological specimens and data. The Biology Core is led by two researchers who have extensive experience collecting biological specimens in large cohort studies. This Core will collaborate extensively with other cores and will provide data, collaboration, and consultation to the subprojects. Proposed activities of the Core will be useful in examining the ability of the U.S. to meet the aggressive goals of multiple prevention efforts, including a 20% improvement in the cardiovascular health of all Americans and a corresponding 20% reduction in CVD deaths by 2020. Such examination will generate actionable, timely knowledge for stakeholders at many levels.