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Diet and fecal incontinence in older women

老年女性的饮食和大便失禁

基本信息

批准号：
9326116
负责人：
Uduak Umoh Andy
金额：
$ 12.08万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-15 至 2021-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9326116
关键词：
Adult Affect Age Aging Animals Bile Acids Butyrates Caregivers Clinical Clinical Research Clinical Trials Clinical effectiveness Cognitive Communities Complex Constipation Consumption Deoxycholic Acid Diarrhea Diet Diet Modification Diet Records Dietary Component Dietary Factors Dietary Fiber Dietary Intervention Effectiveness Elderly Evaluation Exercise Fatigue Fatty acid glycerol esters Fecal Impaction Fecal Incontinence Feces Fiber Focus Groups Future Goals Human Institutionalization Intervention Interview Intestines Knowledge Lithocholic Acid Loperamide Measurement Measures Mentors Metabolism Methodology Methods Modification Patient Self-Report Patients Pelvic Floor Disorders Pelvic floor structure Pharmaceutical Preparations Pilot Projects Plants Quality of life Questionnaires Randomized Recommendation Research Research Methodology Review Literature Role Safety Sampling Severities Symptoms Testing Volatile Fatty Acids Woman Work base career cell motility design epidemiology study experience improved incontinence symptom innovation older women programs reduce symptoms

项目摘要

PROJECT SUMMARY/ABSTRACT Fecal Incontinence (FI) is a debilitating condition that affects up to 17% of community-dwelling adults age 65 and older and is a leading cause of worse quality of life, caregiver fatigue and institutionalization in older women. There is a lack of safe and effective conservative treatments for fecal incontinence in older women. Epidemiological studies show that fecal incontinence in older adults is closely associated with diarrhea and fecal urgency, Recent studies show that the composition of the diet influences the level of bile acids and short-chain fatty acids in the stool, key metabolites that modulate gut motility and consistency of stool. These findings suggest that dietary modifications could significantly improve fecal incontinence in older women. While empirical dietary modifications are often recommended for women with FI there is a key gap in knowledge of specific interventions targeted to older women with FI. In this project, using a mixed methodology approach, we plan to: 1) develop a diet modification program for treating older women with fecal incontinence; 2) estimate the clinical effectiveness of the diet modification program in older women with FI. In addition, we plan to explore mechanisms through which a diet modification program improves FI by examining stool samples for specific metabolites—bile acids and short chain fatty acids. The proposed project is innovative because we plan to develop a diet modification program specifically tailored to older women and will do so using patient input. Measurement of stool metabolites will expand our understanding of mechanisms by which diet affects FI. The proposed project fills a tremendous gap in FI research and will provide older women with a safe and effective option to manage a debilitating condition. The project is feasible as it builds upon the PIs current research expertise and will be guided by a team of mentors with expertise in aging and mixed methodology research. Successful completion of the project will also launch the PIs career in aging related research in pelvic floor disorders.

项目总结/摘要粪便失禁（FI）是一种使人衰弱的疾病，影响高达17%的65岁社区居民是老年人生活质量下降、照顾者疲劳和机构化的主要原因。妇女老年人大便失禁缺乏安全有效的保守治疗方法妇女流行病学研究表明，老年人大便失禁与腹泻和粪便紧迫，最近的研究表明，饮食的组成影响胆汁水平酸和短链脂肪酸，调节肠道运动和一致性的关键代谢产物，凳子这些发现表明，饮食调整可以显着改善大便失禁，年纪大的女人虽然经验性的饮食调整往往是建议妇女与FI有一个关键对针对患有FI的老年妇女的具体干预措施的了解存在差距。在这个项目中，使用混合方法论的方法，我们计划：1）制定一个饮食调整计划，治疗老年妇女大便失禁; 2）评估老年人饮食调整计划的临床有效性女性FI此外，我们计划探索饮食调整计划的机制，通过检查粪便样本中的特定代谢物-胆汁酸和短链脂肪酸来改善FI。建议的项目是创新的，因为我们计划制定一个饮食修改计划，专门为老年妇女，并将这样做，利用病人的意见。粪便代谢物的测量将扩大我们的了解饮食影响FI的机制。拟议的项目填补了FI的巨大空白研究，并将为老年妇女提供一个安全和有效的选择，以管理一个衰弱的条件。的项目是可行的，因为它建立在PI当前的研究专业知识，并将由一个导师团队指导在老龄化和混合方法学研究方面具有专长。该项目的成功完成还将启动从事骨盆底疾病的衰老相关研究。