Synaptopathy and Neural Gain Following Low-Level Noise Exposure

低水平噪声暴露后的突触病和神经增益

• 批准号: 9339318
• 负责人: Adam M Sheppard
• 金额: $ 2.17万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2018-02-11
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9339318
• 关键词: Acoustic Nerve; Action Potentials; Address; Affect; Anatomy; Animal Model; Animals; Audiometry; Auditory; Auditory area; Auditory system; C-Terminal Binding Protein 2; Cochlea; Communication; Complement; Complex; Data; Depressed mood; Environment; Exposure to; Fiber; Frequencies; Glutamate Receptor; Glutamates; Goals; Hair Cells; Human; Hyperacusis; Impairment; Inferior Colliculus; Inherited; Inner Hair Cells; Loudness; Masks; Monitor; Nerve Fibers; Neuronal Plasticity; Noise; Noise-Induced Hearing Loss; Ouabain; Outer Hair Cells; Output; Paper; Peripheral; Physiological; Population; Presynaptic Terminals; Proteins; Rattus; Reporting; Role; Structure; Swelling; Synapses; Synaptic Membranes; Synaptic Receptors; Synaptic plasticity; Temporary Threshold Shift; Time; Tinnitus; auditory pathway; excitotoxicity; hearing impairment; insight; neurophysiology; novel; otoacoustic emission; relating to nervous system; response; ribbon synapse; sound

Project Summary/Abstract Long-duration low-level (LDLL) noise exposures can enhance or depress sound-evoked activity in the auditory cortex (AC), but it’s unclear if these neuroplastic changes originate in the AC or are inherited from lower levels of the auditory pathway. To address this, recordings will be obtained from the cochlea, inferior colliculus (IC) and AC to determine the magnitude and direction of change. To determine if LDLL noise exposures disrupt the neural input to the central auditory pathway, we will evaluate the inner hair cell pre- synaptic ribbons and key proteins expressed on the post-synaptic type I afferent fibers. Our working hypothesis is LDLL noise exposure depresses the neural output of the cochlea, but the central auditory pathway compensates for this by enhancing neural gain at progressively higher levels of the auditory pathway.

项目总结/文摘