Linking genomics of Burkholderia pseudomallei to melioidosis: diversity of clinical manifestations, changing epidemiology and microevolution in chronic carriage.

将类鼻疽伯克霍尔德菌的基因组学与类鼻疽联系起来：临床表现的多样性、流行病学的变化和慢性携带的微进化。

• 批准号: nhmrc : 1046812
• 负责人: A/Pr Apichai Tuanyok
• 金额: $ 40.19万
• 依托单位: Menzies School of Health Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/linking-genomics-burkholderia-chronic-carriage/111876
• 关键词: Linking; genomics; Burkholderia; pseudomallei; melioidosis

The Darwin Prospective Melioidosis Study has documented 761 cases since 1989, with 102 fatalities. This study has led to improved therapy and public health initiatives. New technology to sequence whole bacterial genomes provides an opportunity to determine why urban melioidosis is increasing and to analyse this unique 22+ year set of bacteria and their linked patient data to find the important bacterial virulence factors, forming a foundation for future diagnostics, therapeutics, and vaccines.

自1989年以来，达尔文前瞻性类鼻疽研究记录了761例病例，其中102例死亡。这项研究改善了治疗和公共卫生举措。对整个细菌基因组进行测序的新技术提供了一个机会，可以确定为什么城市类鼻疽正在增加，并分析这一独特的22年以上的细菌及其相关的患者数据，以找到重要的细菌毒力因子，为未来的诊断，治疗和疫苗奠定基础。