ESSENCE (Enabling translation of Science to Service to ENhance Depression CarE)

项目摘要（总体组件） ESSENCE的总体目标（使科学转化为服务，以增强抑郁症的治疗） 弥合科学与服务之间的差距，加强现有的机构合作网络， 南亚由NIMH支持的SHARE Hub（南亚倡导中心， 心理健康研究和教育）， 关于扩大循证干预措施的成本效益高的实施方法的知识 精神障碍，并在一系列关键利益攸关方进行能力建设，以加强 实施研究，传播其研究结果，并在政策和 方案，最终缩小精神障碍治疗差距。规模放大 这一部分将主要有助于知识的生成。Scale-up组件的研究 包括两个互补的，连续的随机对照试验，在五年内进行。 第一个试验（“培训试验”）将测试两种在线培训干预方法， 通过传统的面对面培训，为非专业卫生工作者提供健康活动 计划，一个基于证据的简短的心理治疗抑郁症的初级保健出席者。这 随后将进行一项三组、分组随机对照试验（“实施试验”）， 将评价逐步增加的资源密集型执行支助的影响 整合协作护理以提供基于证据的抑郁症临床治疗的策略 初级保健对病人的结果，服务使用的结果和实施的保真度。的能力 建设部分旨在加强四个南亚国家开展 开展精神卫生研究，传播研究结果，促进知识交流， 促进对研究成果的吸收，以促进基于证据的精神卫生政策制定， 项目规划。行政核心将从现有的行政基础设施发展而来， 共享并负责整体行政、协调、管理和 监测所有组成部分，确保达到里程碑， 各组成部分之间的协调，与各区域的其他倡议联网， 对方案产出和成果的研究吸收。我们设想这三个机构之间将产生强大的协同作用 例如，确保在扩展组件中生成的调查结果 将由专业人士传播，他们将获得指导奖学金， 与扩大规模有关的决策者和方案管理人员的能力建设 这一组成部分将旨在加强知识吸收。这将得到行政当局的有力支持。 核心是为长期的南亚心理健康实施科学中心奠定基础。

PROJECT ABSTRACT (OVERALL COMPONENT) The overall goal of ESSENCE (Enabling translation of Science to Service to ENhance Depression CarE) is to bridge the science to service gap and strengthen an existing collaborative network of institutions in South Asia bound together by the NIMH supported SHARE Hub (the South Asian Hub for Advocacy, Research and Education on mental health) for International Mental Health Research, by generating knowledge on cost-effective implementation approaches for scaling up of evidence based interventions for mental disorders, and building capacity in a range of key stakeholders to enhance the conduct of implementation research, the dissemination of its findings, and the uptake of this evidence in policy and programs, ultimately resulting in reduction of treatment gap for mental disorders. The Scale Up component will primarily contribute to knowledge generation. The research in the Scale up component consists of two complementary, sequential randomized controlled trials, conducted over the five years. The first trial (the “Training trial”) will test two approaches for online training interventions compared with traditional face to face training for Non-Specialists Health Workers to deliver the Healthy Activity Program, an evidence based brief psychological treatment for depression in primary care attenders. This will be followed by a three-arm, cluster randomized controlled trial (the “Implementation trial”) which will evaluate the impact of progressively incremental resource-intensive implementation support strategies to integrate collaborative care to deliver evidence based clinical treatments for depression in primary care on patient outcomes, service use outcomes and implementation fidelity. The Capacity Building component aims to strengthen the capacity in the four South Asian countries to conduct implementation research in mental health, disseminate the findings to facilitate knowledge exchange, and promote the uptake of research findings to facilitate evidence-based mental health policy making and program planning. The Administrative Core will evolve from the existing administrative infrastructure of SHARE and will take responsibility for the overall administration, coordination, management and monitoring of all components, ensuring that the milestones are being met, that there is effective coordination between the components, networking with other initiatives in the regions, and appropriate research uptake of program outputs and outcomes. We envisage strong synergies between all the three components in a variety of ways, for example ensuring that the findings generated in Scale Up component will be disseminated by professionals who are offered mentored fellowships leading to knowledge exchange while Capacity Building of policy makers and program managers concerned with the Scale Up component will aim to enhance knowledge uptake. This will be ably supported by the Administrative Core laying the foundation of a long-term South Asian Mental Health Implementation Science Hub.