ESSENCE (Enabling translation of Science to Service to ENhance Depression CarE)

项目摘要(整体组件) Essence的总体目标(使科学转化为服务以加强抑郁症治疗) 是弥合科学与服务之间的差距，并加强现有的机构合作网络 由NIMH支持的共享中心(The South Asian Hub for Advocacy， 心理健康研究和教育)，国际心理健康研究，通过生成 关于扩大循证干预措施的成本效益实施办法的知识 针对精神障碍，并在一系列关键利益攸关方中建设能力，以加强 执行研究、其结果的传播以及在政策和政策中吸收这一证据 方案，最终导致减少精神障碍的治疗差距。扩大规模 组件将主要有助于知识的生成。放大组件的研究 由两个相辅相成的顺序随机对照试验组成，在五年内进行。 第一个试验(“培训试验”)将测试两种比较的在线培训干预方法 与传统的非专科医务人员面对面培训，提供健康的活动 这是一项以证据为基础的针对初级保健照顾者抑郁的简短心理治疗。这 随后将进行一项三组随机对照试验(“实施试验”) 将评估逐步增加的资源密集型实施支持的影响 整合协作护理的策略，以提供基于证据的抑郁症临床治疗 初级保健对患者结果、服务使用结果和实施保真度的影响。容量 建设部分旨在加强在南亚四国开展 实施精神健康研究，传播研究结果以促进知识交流；以及 促进研究结果的采纳，以促进以证据为基础的精神卫生政策的制定和 节目策划。行政核心将从现有的行政基础设施演变而来 分享并将负责整个行政、协调、管理和 监控所有组件，确保达到里程碑，确保有效 各组成部分之间的协调，与区域内其他倡议的联网，以及适当的 对项目产出和结果进行研究。我们预见到这三个方面之间将产生强大的协同效应 以各种方式，例如，确保在纵向扩展组件中生成的调查结果 将由专业人员传播，这些专业人员将获得引导知识的导师奖学金 关注扩大规模的政策制定者和项目经理的边交流边能力建设 该构成部分的目的将是加强知识吸收。这将得到行政部门的有力支持 为长期的南亚精神卫生实施科学中心奠定基础。

PROJECT ABSTRACT (OVERALL COMPONENT) The overall goal of ESSENCE (Enabling translation of Science to Service to ENhance Depression CarE) is to bridge the science to service gap and strengthen an existing collaborative network of institutions in South Asia bound together by the NIMH supported SHARE Hub (the South Asian Hub for Advocacy, Research and Education on mental health) for International Mental Health Research, by generating knowledge on cost-effective implementation approaches for scaling up of evidence based interventions for mental disorders, and building capacity in a range of key stakeholders to enhance the conduct of implementation research, the dissemination of its findings, and the uptake of this evidence in policy and programs, ultimately resulting in reduction of treatment gap for mental disorders. The Scale Up component will primarily contribute to knowledge generation. The research in the Scale up component consists of two complementary, sequential randomized controlled trials, conducted over the five years. The first trial (the “Training trial”) will test two approaches for online training interventions compared with traditional face to face training for Non-Specialists Health Workers to deliver the Healthy Activity Program, an evidence based brief psychological treatment for depression in primary care attenders. This will be followed by a three-arm, cluster randomized controlled trial (the “Implementation trial”) which will evaluate the impact of progressively incremental resource-intensive implementation support strategies to integrate collaborative care to deliver evidence based clinical treatments for depression in primary care on patient outcomes, service use outcomes and implementation fidelity. The Capacity Building component aims to strengthen the capacity in the four South Asian countries to conduct implementation research in mental health, disseminate the findings to facilitate knowledge exchange, and promote the uptake of research findings to facilitate evidence-based mental health policy making and program planning. The Administrative Core will evolve from the existing administrative infrastructure of SHARE and will take responsibility for the overall administration, coordination, management and monitoring of all components, ensuring that the milestones are being met, that there is effective coordination between the components, networking with other initiatives in the regions, and appropriate research uptake of program outputs and outcomes. We envisage strong synergies between all the three components in a variety of ways, for example ensuring that the findings generated in Scale Up component will be disseminated by professionals who are offered mentored fellowships leading to knowledge exchange while Capacity Building of policy makers and program managers concerned with the Scale Up component will aim to enhance knowledge uptake. This will be ably supported by the Administrative Core laying the foundation of a long-term South Asian Mental Health Implementation Science Hub.