Reward processing in frontotemporal dementia

额颞叶痴呆的奖励处理

• 批准号: 9271132
• 负责人: DAVID C PERRY
• 金额: $ 19.76万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-15 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9271132
• 关键词: Affect; Aging; Alzheimer' s Disease; Anatomy; Animal Disease Models; Animal Model; Anterior; Behavior; Behavioral; Behavioral Symptoms; Biological; Biological Markers; Biometry; Brain; Brain region; California; Clinical Research; Clinical Trials; Cognitive; Data Collection; Dementia; Desire for food; Development; Diagnosis; Disease; Disease model; Disinhibition; Dopamine; Eating Disorders; Elderly; Elements; Emotional; Family; Food; Frontotemporal Dementia; Functional Imaging; Future; Galvanic Skin Response; Globus Pallidus; Goals; Heart Rate; Hyperphagia; Impairment; Individual; Insula of Reil; Knowledge; Laboratories; Laboratory Finding; Lead; Learning; Life; Measures; Memory; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Modality; Modeling; Neurodegenerative Disorders; Neurologist; Neurosciences; Nucleus Accumbens; Opioid; Patients; Pharmacological Treatment; Physiological; Positive Valence; Prefrontal Cortex; Problem behavior; Process; Psychiatrist; Psychophysiology; Punishment; Regulation; Reporting; Research; Research Personnel; Rewards; San Francisco; Satiation; Serotonergic System; Severities; Sex Behavior; Social Behavior; Specialist; Stimulus; Structure; Substance abuse problem; Symptoms; System; Task Performances; Techniques; Testing; Training; Translating; Universities; Update; Ventral Striatum; Ventral Tegmental Area; Work; base; behavioral neurology; behavioral variant frontotemporal dementia; career; craving; daily functioning; disorder control; drug testing; effective therapy; emotional behavior; executive function; experience; improved; informant; neuroimaging; neuropsychiatric symptom; novel; olfactory stimulus; patient oriented; professor; public health relevance; response; reward processing; social; symptom management; symptom treatment; tool

DESCRIPTION (provided by applicant): This is an application for a K23 award for Dr. David Perry, a behavioral neurology fellow at the University of California, San Francisco Memory and Aging Center (MAC). Dr. Perry is establishing himself as a young investigator in patient-oriented clinical research of reward processing in neurodegenerative disease. This K23 award will provide Dr. Perry with the support necessary to accomplish the following goals: 1) to gain expertise in neurodegenerative disease and neuropsychiatric symptom management; 2) to develop proficiency in the use and analysis of structural and functional neuroimaging; 3) to gain experience in the use of psychophysiological measures; 4) to advance his knowledge of biostatistics [and clinical trials]; and 5) to develop an independent clinical research career. To achieve these goals, Dr. Perry has assembled a mentoring team comprised of two primary mentors: Dr. Howard Rosen (a neurologist with expertise in neurodegenerative disease, psychophysiology, and neuroimaging analysis) and Dr. Joel Kramer (a neuropsychologist with expertise in cognitive and behavioral systems); one co-mentor, Dr. Bruce Miller (neurologist with expertise in behavioral neurology, neurodegenerative disease, and clinical research); and five consultants: [Dr. Craig Nelson (a geriatric psychiatrist), Dr. Chiadi Onyike (a geriatric psychiatrist and specialist in behavioral variant frontotemporal dementia (bvFTD)), Dr. Adam Boxer (a neurologist with expertise in clinical trials in bvFTD),] Dr. John Neuhaus (a biostatistician) and Dr. Mark D'Esposito (a professor of neuroscience with expertise in functional neuroimaging and reward processing). The proposed research will examine reward processing in bvFTD. Reward processing involves a determination of what an individual will pursue or work for, such as food, money, or social approval. Dr. Perry will administer laboratory tasks of reward processing to patients with bvFTD, Alzheimer's disease, and healthy control subjects to determine the aspect of valuation of reward that is altered in bvFTD (Aim 1). Dr. Perry will correlate the findings from these laboratory tasks with structural and functional imaging to determine the anatomic correlates of these behaviors (Aim 2) and with real-life functional measures to determine the effect reward processing changes have in patients' lives (Aim 3). Data collection will take place at the MAC. The results of this research will improve understanding of the behavioral symptoms in bvFTD, will direct future studies into symptomatic treatment in the illness, will provide objective tests to distinguish neurodegenerative diseases, and will offer reward-based measures as an additional tool for use in animal models of bvFTD. This K23 training will enable Dr. Perry to apply concepts of reward processing to the understanding of other neurodegenerative diseases.

描述（由申请人提供）：这是加州大学旧金山记忆与衰老中心 (MAC) 行为神经学研究员 David Perry 博士的 K23 奖申请。佩里博士正在将自己定位为一名年轻的研究者，致力于以患者为导向的神经退行性疾病奖励处理临床研究。该 K23 奖项将为佩里博士提供实现以下目标所需的支持：1）获得神经退行性疾病和神经精神症状管理方面的专业知识； 2）培养结构和功能神经影像学的使用和分析能力； 3）获得使用心理生理学措施的经验； 4) 提高生物统计学[和临床试验]知识； 5）发展独立的临床研究事业。为了实现这些目标，Perry 博士组建了一个由两位主要导师组成的指导团队：Howard Rosen 博士（在神经退行性疾病、心理生理学和神经影像分析方面具有专业知识的神经学家）和 Joel Kramer 博士（在认知和行为系统方面具有专业知识的神经心理学家）；一位共同导师 Bruce Miller 博士（具有行为神经学、神经退行性疾病和临床研究专业知识的神经学家）；和五位顾问：[Dr. Craig Nelson（老年精神病学家）、Chiadi Onyike 博士（老年精神病学家和行为变异型额颞叶痴呆 (bvFTD) 专家）、Adam Boxer 博士（具有 bvFTD 临床试验专业知识的神经学家）、] John Neuhaus 博士（生物统计学家）和 Mark D'Esposito 博士（行为变异型额颞叶痴呆 (bvFTD) 教授） 神经科学，具有功能性神经影像和奖励处理方面的专业知识）。 拟议的研究将检查 bvFTD 中的奖励处理。奖励处理涉及确定个人将追求或工作的目标，例如食物、金钱或社会认可。 Perry 博士将对患有 bvFTD、阿尔茨海默氏病和健康对照受试者的奖励处理实验室任务进行管理，以确定 bvFTD 中奖励评估方面的改变（目标 1）。 Perry 博士将把这些实验室任务的结果与结构和功能成像联系起来，以确定这些行为的解剖学相关性（目标 2），并将其与现实生活中的功能测量联系起来，以确定奖励处理变化对患者生活的影响（目标 3）。数据收集将在 MAC 进行。这项研究的结果将增进对 bvFTD 行为症状的理解，指导未来对该疾病的对症治疗的研究，提供客观测试来区分神经退行性疾病，并将提供基于奖励的措施作为 bvFTD 动物模型中使用的附加工具。此次 K23 培训将使 Perry 博士能够将奖励处理的概念应用于理解其他神经退行性疾病。