Multidisciplinary Schizophrenia Research Training

 描述(由申请人提供)：这是马里兰州精神病学研究中心(MPRC)T32培训补助金的第二次竞争性续签，最初资助于2003年(MH067533)。该计划的目标是培养对基础或临床研究感兴趣的医学博士、博士和药学博士，以便从事精神分裂症相关障碍的翻译研究。MPRC是马里兰大学医学院的一个有组织的研究中心，也是精神病学系的一个部门，是一个专注于精神分裂症和相关疾病研究的中心，位于斯普林格罗夫医院中心的场地上，斯普林格罗夫医院中心是位于巴尔的摩郊外的马里兰州住院精神卫生机构。MPRC的教职员工有一个临床和神经科学研究的综合研究项目，涉及神经成像、神经生理学、生物化学、啮齿动物模型、病因、症状、内表型、神经认知、精神病理学领域以及与精神分裂症和相关疾病相关的特定病理的实验疗法。所有教员都成功地利用竞争性的研究资金和MPRC以及整合和协作框架为NIMH P50奖项提供了超过25年的支持，包括刚刚完成的CIDAR和刚刚资助的COTE中心。MPRC的特点是临床前和临床研究人员之间频繁的互动和合作。这一背景使MPRC的教员们在支持NIMH研讨会为RDoC倡议开发行为结构方面发挥了积极作用。通过与附近的马里兰大学巴尔的摩大学医学院和药学院的其他部门的广泛参与，丰富了科学机会和合作。根据这一T32奖学金提供的博士后培训主要集中在基础神经科学和精神分裂症及相关障碍的临床调查上。所有受训人员都接受了关于MPRC翻译观点的教育，并提供临床和神经科学方面的指导和教学培训。这项具有竞争力的五年续期申请的续期申请建议继续每年资助5个职位，每个职位一个研究金，为期2-3年。这个T32项目在招募和培训博士后研究员以从事科学事业方面是成功的，包括临床科学家。该项目的毕业生在富有成效的、成功的研究密集型职业生涯中处于领先地位。进度报告提供了毕业生和现任研究员的详细情况。

 DESCRIPTION (provided by applicant): This is the second competitive renewal of a T32 training grant at the Maryland Psychiatric Research Center (MPRC), originally funded in 2003 (MH067533). The goal of the proposed program is to prepare MDs, PhDs and PharmDs interested in basic or clinical research for a career in translational research in schizophrenia related disorders. The MPRC, an Organized Research Center of the University of Maryland School of Medicine and division of the Department of Psychiatry, is a focused center for research on schizophrenia and related disorders, located on the grounds of the Spring Grove Hospital Center, a State of Maryland inpatient mental health facility located just outside Baltimore. Faculty at the MPRC have an integrated research program of clinical and neuroscience research involving neuroimaging, neurophysiology, biochemistry, rodent models, etiologic factors, symptoms, endophenotypes, neurocognition, domains of psychopathology and experimental therapeutics for specific pathologies associated with schizophrenia and related disorders. All faculty are successful with competitive research funding and the MPRC and the integrated and collaborative framework has supported NIMH P50 awards for over 25 years including a just completed CIDAR and just funded Conte centers. The MPRC is characterized by frequent interaction and collaboration among preclinical and clinical investigators. This background prepared faculty at MPRC to take an active role in supporting NIMH workshops developing behavioral constructs for the RDoC initiative. Scientific opportunities and collaborations are enriched with extensive involvement with other components of the University of Maryland School of Medicine and School of Pharmacy at the nearby University of Maryland Baltimore. Postdoctoral training offered under this T32 fellowship has a primary focus on both basic neuroscience and clinical investigations of schizophrenia and related disorders. All trainees are educated on the translational perspective of the MPRC and provided mentors and didactic training in both clinical and neuroscience. This renewal for a competitive five- year renewal application proposes to continue funding 5 positions a year with each a fellowship lasting for 2-3 years. This T32 program is successful in terms of recruiting and training post-doctoral fellows for a scientific career including clinician scientists. Graduates of the program lead productive, successful research-intensive careers. Details on graduates and the present fellows are provided in the progress report.