A 3T Scanner for Establishing UM MPRC Neuroimaging Research Facility

用于建立 UM MPRC 神经影像研究设施的 3T 扫描仪

• 批准号: 7842843
• 负责人: William T. Carpenter
• 金额: $ 283.05万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-20 至 2012-05-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7842843
• 关键词: American; Baltimore; Brain imaging; Chemicals; Clinical; Clinical Trials; Computer software; County; Environment; Funding; Future; Goals; Image; Inpatients; Institution; Location; Maintenance; Maryland; Measures; Mentally Ill Persons; Occupations; Outpatients; Recovery; Relative (related person); Request for Applications; Research; Research Personnel; Research Training; Resistance; Sales; Science; Scientific Advances and Accomplishments; Staging; Symptoms; System; Techniques; United States National Institutes of Health; Universities; behavior measurement; brain research; cognitive enhancement; college; experience; medical schools; neuroimaging; novel; operation; research facility; response; severe mental illness; translational neuroscience

DESCRIPTION (provided by applicant): Project summary: This application requests funds to purchase a 3T scanner system to establish a research-dedicated neuroimaging facility at the University of Maryland (UM) System. This is in response to the Recovery Act Limited Competition (S10) PAR-09-118. We propose to install the facility at the Maryland Psychiatric Research Center (MPRC). The MPRC is centrally located among the UM campuses. MPRC has both inpatient and outpatient psychiatric research units and is a location that offers unique clinical and collaborative research opportunities. It provides an opportunity to study novel pharmacological compounds for cognitive enhancement and symptom reduction in severe mental illnesses and conduct inpatient neuroimaging research for treatment-resistant mentally ill. It will enable imaging endpoint measures for our extensive novel compound clinical trials, most of which are currently limited to behavioral measures and clinical ratings due to the lack of an onsite scanner. This will also be the first dedicated brain research scanner available for the UM campuses. The facility will serve investigators at four campuses: UM Baltimore and UMB School of Medicine (UMB, UMSOM), UM Baltimore County (UMBC), UM College Park (UMCP), and MPRC. The MPRC is directly across the street from the UMBC campus and centrally located relative to the other campuses and is easily accessible. Current imaging-related research at the four UM campuses includes multiple departments. There is a substantial group of senior investigators with neuroimaging projects that are currently being conducted at outside imaging facilities. The highest concentration of brain imaging investigators across UM campuses is located at the MPRC. These researchers have extensive imaging experience that includes structural, functional, and chemical MR techniques, thus providing a supportive environment for users from all campuses. We also have a group of junior investigators in early and late stages of neuroimaging research training who would greatly benefit from a dedicated research facility. Overall, the unique arrangement will serve two important functions: 1) Enable neuroimaging research for inpatient and clinical trials in severe mental illnesses that would otherwise be impossible without an onsite scanner; and 2) Greatly enhance the already substantial clinical and translational neuroscience efforts across the UM campuses. This facility will significantly advance the scientific goals of ongoing and future NIH funded imaging studies. We have a detailed and ready-to-execute plan for installation and operation that includes sophisticated hardware and software expertise and support, and a full commitment from our institutions. This project, if funded, will provide a substantial number of American jobs in sales, construction, and maintenance sectors associated with the purchase. Once it is in place, the facility will substantially facilitate science related job creation and retention. 0

项目概述：本申请申请资金用于购买3T扫描仪系统，以在马里兰大学（UM）系统建立一个研究专用的神经成像设施。这是对恢复法案有限竞争（S10） PAR-09-118的回应。我们建议在马里兰精神病学研究中心（MPRC）安装该设备。MPRC位于UM校区的中心。MPRC有住院和门诊精神病学研究单位，是一个提供独特的临床和合作研究机会的地方。它提供了一个机会来研究新的药理化合物，以增强认知和减轻严重精神疾病的症状，并为治疗难治性精神疾病进行住院神经影像学研究。它将为我们广泛的新型化合物临床试验提供成像终点测量，由于缺乏现场扫描仪，大多数临床试验目前仅限于行为测量和临床评级。这也将是首台为澳大校园提供的专用大脑研究扫描仪。该设施将为四个校区的研究人员提供服务：UM巴尔的摩和UMB医学院（UMB， UMSOM）， UM巴尔的摩县（UMBC）， UM大学公园（UMCP）和MPRC。MPRC就在UMBC校园的街对面，相对于其他校园位于中心位置，交通方便。目前，澳大四个校区的影像相关研究包括多个院系。有一大批高级研究人员目前正在外部成像设施进行神经成像项目。MPRC是澳大各校区脑成像研究人员最集中的地方。这些研究人员拥有丰富的成像经验，包括结构、功能和化学磁共振技术，因此为所有校园的用户提供了一个支持性的环境。我们也有一组初级研究人员在神经影像学研究培训的早期和后期阶段，他们将极大地受益于一个专门的研究设施。总的来说，这种独特的安排将有两个重要的功能：1)使严重精神疾病的住院和临床试验的神经影像学研究成为可能，否则没有现场扫描仪是不可能的；2)大大加强在澳大校园内已经大量的临床和转化神经科学工作。该设施将显著推进正在进行和未来NIH资助的成像研究的科学目标。我们有一个详细的、随时可执行的安装和操作计划，包括复杂的硬件和软件专业知识和支持，以及我们机构的全面承诺。该项目如果获得资助，将在与采购相关的销售、建筑和维修部门为美国人提供大量就业机会。一旦到位，该设施将大大促进与科学相关的就业创造和保留。0