Recombinant Silk Elastin-like Protein Polymers for the Embolization of Cerebral Aneurysms

叙事 STTR 第一阶段提案详细介绍了开发新型液体的基本原理和研究计划 由基因工程蛋白质聚合物 SELP（丝弹性蛋白）组成的栓塞剂 蛋白）-815K，栓塞脑动脉瘤。 SELP 栓塞将降低动脉瘤的风险 破裂，同时最大限度地降低治疗后再通的风险，并提供一个分娩平台 新开发的药物或细胞疗法直接作用于动脉瘤囊。这项工作将导致栓塞 可以潜在地改善动脉瘤愈合、局部治疗并降低与动脉瘤相关的风险 脑动脉栓塞。

NARRATIVE This STTR Phase I proposal details the rationale and the research plan for the development of a novel liquid embolizing agent composed of the genetically engineered protein polymer, SELP (silk-elastinlike protein)-815K, to embolize cerebral aneurysms. The SELP embolic would reduce the risk of aneurysm rupture while minimizing the risk of recanalization after treatment and providing a platform for delivering newly developed drugs or cell therapies directly to the aneurysmal sac. This work will result in an embolic that can potentially improve aneurysm healing, deliver therapeutics locally, and reduce the risks associated with the embolization of cerebral arteries.