Non-invasive biosensors to detect cardiovascular changes in heart failure

无创生物传感器检测心力衰竭时的心血管变化

• 批准号: 9270589
• 负责人: Omer Tolga Inan
• 金额: $ 56.76万
• 依托单位: GEORGIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-15 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9270589
• 关键词: Accelerometer; Activities of Daily Living; Address; Affect; Algorithms; Ambulatory Care; American; Ballistocardiography; Biomechanics; Biosensor; Blood Pressure; Blood Volume; Blood capillaries; Body Weight; Cardiac Catheterization Procedures; Cardiac Output; Cardiac Surgery procedures; Cardiac rehabilitation; Cardiopulmonary; Cardiovascular Physiology; Cardiovascular system; Caregivers; Caring; Clinical; Clothing; Continuity of Patient Care; Data; Devices; Diagnosis; Dobutamine; Elderly; Electrocardiogram; Electrodes; Energy Metabolism; Evaluation; Exercise; Feedback; Foundations; Goals; Health; Health Care Costs; Heart Rate; Heart failure; Home environment; Hospitalization; Hospitals; Incidence; Indirect Calorimetry; Infusion procedures; Life; Measurement; Measures; Medicare; Metabolic; Mining; Modality; Monitor; Morphologic artifacts; Motion; Myocardial Infarction; Nitroprusside; Outcome; Patient Monitoring; Patients; Photoplethysmography; Physiologic Monitoring; Physiologic pulse; Physiological; Physiology; Population; Predictive Analytics; Probability; Pulmonary artery structure; Quality of life; Research; Resolution; Rest; Risk; Signal Transduction; Societies; Solid; Stress Tests; Stroke Volume; Study Subject; Surface; Symptoms; System; Techniques; Technology; Temperature; Testing; Time; Treatment Failure; Walking; Wedge Pressures; barometric pressure; base; capillary; cardiovascular health; cost; design; experience; heart rate variability; hemodynamics; implantable device; improved; innovation; monitoring device; new technology; novel; patient population; prediction algorithm; pressure; prevent; programs; prototype; public health relevance; respiratory; response; sensor; stressor; usability; vibration; walking speed

 DESCRIPTION (provided by applicant): Heart failure (HF) is one of the most major challenges faced by society today, claiming hundreds of thousands of American lives each year and costing more than 30 billion Medicare dollars annually. The ultimate goal of this research is to create an unobtrusive wearable system for continuously monitoring HF patients in naturalistic settings, automatically assessing their risk of experiencing an exacerbation, and providing feedback to caregivers and the patients themselves. The central innovation that will support these efforts is the proposed measurement of hemodynamic responses to stressors experienced in normal activities of daily living (e.g., walking, climbing stairs). The measurement of such hemodynamic responses will be enabled by wearable ballistocardiography (BCG). The following four specific aims are proposed for the research: (1) to elucidate the underlying mechanisms involved in the genesis of wearable ballistocardiogram (BCG) signals; (2) to develop novel predictive analytics algorithms for BCG signals measured from HF patients at home; (3) to design and implement a wearable sensing system for estimating cardiac output (CO), blood pressure (BP), and indirect calorimetry from ambulant subjects; and (4) to evaluate the wearable sensing system with healthy and HF patients during cardiopulmonary stress testing, and to pilot the new system at home for a small population of patients. The first aim will build a strong foundation for better understanding the wearable BCG signal - a measurement of body vibrations in response to the heartbeat - and will inform the placement and modality of the sensor for optimizing the sensing. Furthermore, the evaluation of this wearable prototype will include usability testing to assess comfort and robustness to practical challenges (e.g., motion artifacts, the device rubbing on clothing), and based on the results the design will be refined and improved. While we anticipate that the wearable will provide the best solution, the project risk is mitigated through the more mature, existing scale- based system. Successful completion of this project could ultimately reduce HF related hospitalizations, and thus both improve quality of life for elderly Americans, and reduce overall healthcare costs.

 心力衰竭（HF）是当今社会面临的最主要挑战之一，每年夺去数十万美国人的生命，每年花费超过300亿医疗保险美元。这项研究的最终目标是创建一个不显眼的可穿戴系统，用于在自然环境中持续监测HF患者，自动评估他们经历急性加重的风险，并向护理人员和患者本身提供反馈。支持这些努力的核心创新是提出了对日常生活正常活动中经历的应激源的血流动力学反应的测量（例如，步行、爬楼梯）。可穿戴式心冲击描记术（BCG）将能够测量此类血液动力学反应。本研究提出了以下四个具体目标：（1）阐明可穿戴心冲击图（BCG）信号产生的潜在机制;（2）开发新的预测分析算法，用于在家中测量HF患者的BCG信号;（3）设计和实现一种可穿戴传感系统，用于估计非卧床受试者的心输出量（CO）、血压（BP）和间接热量测定;以及（4）在心肺压力测试期间对健康和HF患者评估可穿戴感测系统，并在家中对小部分患者试用新系统。第一个目标将为更好地理解可穿戴BCG信号奠定坚实的基础-测量响应心跳的身体振动-并将为传感器的放置和模态提供信息，以优化传感。此外，对这种可穿戴原型的评估将包括可用性测试，以评估舒适性和对实际挑战的鲁棒性（例如，运动伪影、设备在衣服上的摩擦），并且基于结果将细化和改进设计。虽然我们预计可穿戴设备将提供最佳解决方案，但通过更成熟的现有基于规模的系统减轻了项目风险。该项目的成功完成可能最终减少HF相关的住院治疗，从而提高美国老年人的生活质量，并降低整体医疗保健成本。