Informatics Core

信息学核心

• 批准号: 9359457
• 负责人: SARAH ANNE COOLEY
• 金额: $ 6.72万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-17 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9359457
• 关键词: Adverse event; Alleles; Basic Science; Bioinformatics; Biological Sciences; Cancer Center; Clinical; Clinical Research; Clinical Trials; Cloning; Collection; Communities; Complex; Core Grant; Custom; Data; Data Analyses; Data Collection; Data Files; Data Quality; Data Security; Data Set; Databases; Development; Ensure; Equipment and supply inventories; Extensible Markup Language; Faculty; Frequencies; GEM gene; Generations; Genetic; Grant; Haplotypes; Health Insurance Portability and Accountability Act; Immunogenetics; Informatics; Laboratories; Laboratory Research; Maintenance; Management Information Systems; Medical Informatics; Medical Oncology; Methodology; Minnesota; Multicenter Trials; Natural Killer Cells; Persons; Phase; Process; Program Research Project Grants; Regulation; Reporting; Research; Research Infrastructure; Research Institute; Research Personnel; Resource Sharing; Safety; Sampling; Services; Site; Source; Teleconferences; Toxic effect; Translational Research; Transplantation; United Kingdom; United States National Institutes of Health; Universities; Update; Work; base; cancer therapy; cohort; dashboard; data access; data integration; data integrity; data management; data sharing; design; informatics infrastructure; member; novel; oncology; programs; prospective; receptor; research study; tool

The function of the Bioinformatics and Data Management Core is to provide the informatics infrastructure, analysis tools and specialized expertise required to support the complex data analysis, integration and storage needs of this Projects and Cores of this grant. Led by Dr. Sarah Cooley, Director of the Masonic Cancer Center Oncology Medical Informatics & Services (OMIS) shared resource, it is composed of two teams providing bioinformatics (UK Team; Anthony Nolan Research Institute) and clinical research data management support (MN team: OMIS). The two groups will meet in person annually and have teleconferences at least every 4 months to ensure the efficient and integrated management of the Core. The MN team is responsible for the development and maintenance of database applications to collect, integrate and report research data generated by the projects for subsequent analysis. In addition they will support and customize the clinical trials management applications to meet the research and regulatory data requirements for the complex (phase I, IND, multi-center) trials in Project 3. The sharing of research samples processed and analyzed by Core D will be coordinated through this Core with a customized sample inventory management tool. Lastly, this team will ensure data quality, data integrity, and data sharing, in compliance with HIPAA regulation and NIH principles. The UK Team will provide bioinformatics support by developing the IPD-KIR Database which will facilitate the work of both the global research community and the grant members. They will continue to collect and curate the KIR sequence data and provide regular updates of this data to allow further development of the typing and sequencing strategies for KIR determination. These developments will include custom bioinformatics tools and applications specifically designed to aid research by other grant members. An expanded suite of bespoke analysis tools will be imbedded to allow advanced analysis for non- Bioinformaticians. A key aim of the IPD project is to provide high quality data that can easily be retrieved and used by non-Bioinformaticians. This can be seen in the work of the IMGT/HLA Database where high level data files, XML, are available for Bioinformaticians, but also tools with easy to use interfaces are provided to allow data analysis possible for a wider range of researchers. They will fully characterize novel KIR sequences detected in Project 1 (SA3) and ensure these data are represented in the public database this will be achieved by conventional cloning methodologies and employing third generation sequencing strategies on the Pacific Biosciences RS II platform. The scientific expertise provided by this team will be invaluable to analyze and interpret immunogenetic data.

生物信息学和数据管理核心的功能是提供信息学 支持复杂数据分析所需的基础架构，分析工具和专业知识， 该项目的集成和存储需求。由莎拉·库利（Sarah Cooley）博士领导 共济会癌症中心肿瘤学医学信息学和服务（OMIS）共享资源，由它组成 提供生物信息学的两个团队（英国团队；安东尼·诺兰研究所）和临床研究数据 管理支持（MN团队：OMIS）。两组将每年亲自见面，并 至少每4个月每4个月进行电视会议，以确保核心的高效和集成管理。 MN团队负责开发和维护数据库应用程序以收集， 整合和报告项目生成的研究数据以进行后续分析。另外，他们将 支持并自定义临床试验管理应用程序，以满足研究和监管数据 项目3中复杂（I期，IND，多中心）试验的要求。研究样本的共享 通过核心D进行处理和分析，将通过此核心协调定制样本清单 管理工具。最后，该团队将确保按照合规性确保数据质量，数据完整性和数据共享 与HIPAA法规和NIH原则。 英国团队将通过开发IPD-KIR数据库来提供生物信息学支持 促进全球研究界和赠款成员的工作。他们将继续收集 并策划KIR序列数据并定期更新此数据，以便进一步开发 确定KIR的打字和测序策略。这些发展将包括自定义 生物信息学工具和应用程序专门旨在帮助其他赠款成员的研究。一个 扩展的定制分析工具套件将被嵌入，以允许对非 - 生物信息学家。 IPD项目的关键目的是提供可以轻松检索的高质量数据，并且 非生物信息学家使用。这可以在IMGT/HLA数据库的工作中看到高级数据 XML文件可用于生物信息学家，但还提供了易于使用界面的工具以允许 可以针对更广泛的研究人员进行数据分析。他们将完全表征新颖的KIR序列 在项目1（SA3）中检测到，并确保在公共数据库中表示这些数据 通过传统的克隆方法和对太平洋采用第三代测序策略 生物科学RS II平台。该团队提供的科学专业知识将是无价的分析和 解释免疫发生数据。