CLINICAL DEVELOPMENT OF TWO REPLICATION-DEFECTIVE CHIMPANZEE ADENOVIRUS (ADC) VECTORS, TERMED ADC6 AND ADC7

这项活动的目的是为多功能团队提供支持，以先进的开发和生产HIV候选疫苗，这些候选疫苗已在非人灵长类动物（NHP）挑战研究、等效临床前动物模型或早期人类临床试验中取得成功，并已证明生产可行性。 所支持的活动将有助于进一步发展目前领先的艾滋病毒疫苗平台。感兴趣的平台包括重组HIV蛋白、POX病毒、DNA疫苗、复制检测腺病毒载体和腺相关病毒载体。

The intent of this activity is to provide support to multifunctional teams for advanced development and manufacture of HIV vaccine candidates that have demonstrated success in non-human primate (NHP) challenge studies, equivalent preclinical animal models or early human clinical trials, and have demonstrated manufacturing feasibility. The supported activities will allow the further development of the current leading HIV vaccine platforms. Platforms of interest include, recombinant HIV proteins, POX viruses, DNA vaccines, replication detective adenovirus vectors, and adeno-associated virus vectors.