Comp C-National SB Urologic Protocol at Vanderbilt Children's Hospital

Comp C-范德比尔特儿童医院国家 SB 泌尿科方案

• 批准号: 9334554
• 负责人: Stacy T Tanaka
• 金额: $ 2.05万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9334554
• 关键词: Comp; National; SB; Urologic; Protocol

DESCRIPTION (provided by applicant): Advances in medical care have increased longevity for babies born with spina bifida, the most common permanently disabling birth defect in the United States. The main goals of the urologist participating in the care or patients with spina bifida are: 1) to preserve normal renal function and 2) to ensure adequate bladder continence for enhancing self-esteem and independence. Despite these common goals, practice patterns vary, and best practices are not well defined. The CDC has demonstrated the feasibility of a National Spina Bifida Patient Registry (NSBPR). A Urologic Management to Preserve Renal Function Protocol (UPPF) has also been designed to evaluate outcomes on a standardized urologic protocol from the neonatal period to 5 years of age. The Spina Bifida Program at Monroe Carell Jr. Children's Hospital at Vanderbilt (MCJCHV) evaluates approximately 20 newborns with spina bifida each year. In partnership with the neonatal intensive care unit, all the pediatric urologists at MCJCHV have set the following goals for this study: 1) to approach each eligible patient in our program for enrollment, 2) to contribute longitudinal data on diagnostic studies and interventions as specified by the protocol, and 3) to evaluate data from the NSBPR and UPPF to answer hypothesis-driven questions specifically about clinical predictors for hostile videourodynamics and decreased renal function. The PI along with the clinical research coordinator will ensure quality control of data submitted to the CDC. The PI and senior/key personnel have a demonstrated record of productive research with other national databases and federally funded grants. Published results from this study will help to inform best practice clinical guidelines for urologic management in the child with spina bifida

描述（由申请人提供）：医疗保健的进步增加了脊柱裂婴儿的寿命，脊柱裂是美国最常见的永久性残疾出生缺陷。泌尿科医生参与脊柱裂患者护理的主要目标是：1）保持正常的肾功能和2）确保足够的膀胱扩张，以增强自尊和独立性。尽管有这些共同的目标，但实践模式各不相同，最佳实践也没有很好的定义。CDC已经证明了国家脊柱裂患者登记处（NSBPR）的可行性。还设计了一个泌尿外科管理以保护肾功能方案（UPPF），以评价从新生儿期到5岁的标准化泌尿外科方案的结局。小门罗卡雷尔的脊柱裂项目。范德比尔特儿童医院（MCJCHV）每年评估大约20名患有脊柱裂的新生儿。与新生儿重症监护室合作， MCJCHV的儿科泌尿科医生为这项研究设定了以下目标：1）接近我们计划中的每一位合格患者，2）根据方案规定提供诊断研究和干预措施的纵向数据，3）评估NSBPR和UPPF的数据，以回答假设驱动的问题，特别是关于敌对视频尿动力学和肾功能下降的临床预测因素。PI沿着临床研究协调员将确保对提交给CDC的数据进行质量控制。PI和高级/关键人员具有与其他国家数据库和联邦资助的赠款进行生产性研究的证明记录。本研究发表的结果将有助于为脊柱裂患儿的泌尿外科治疗提供最佳实践临床指南