Amyloid Beta-Protein: Wild Type and Familial Mutant Assembly and Inhibition

β-淀粉样蛋白：野生型和家族突变体的组装和抑制

• 批准号: 9110110
• 负责人: Michael Thomas Bowers
• 金额: $ 44.23万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA BARBARA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9110110
• 关键词: Alzheimer' s Disease; Amyloid beta-Protein; Amyloidosis; Data; Detection; Effectiveness; Etiology; Family; Heart; Length; Light; Mass Spectrum Analysis; Measures; Methods; Modeling; Molecular; Molecular Models; Peptides; Process; Property; Reagent; Reporting; Research; Structure; System; Techniques; Therapeutic Agents; Work; abstracting; base; beta pleated sheet; inhibitor/antagonist; ion mobility; molecular modeling; monomer; mutant; protein aggregation; small molecule; tau Proteins; tau function; therapeutic target

No abstract provided

未提供摘要

项目成果

Tau assembly: the dominant role of PHF6 (VQIVYK) in microtubule binding region repeat R3.

Tau组装：PHF6（VQIVYK）在微管结合区域重复R3中的主要作用。

• DOI: 10.1021/acs.jpcb.5b00175
• 发表时间: 2015-04-02
• 期刊: JOURNAL OF PHYSICAL CHEMISTRY B
• 影响因子: 3.3
• 作者: Ganguly, Pritam;Do, Thanh D.;Larini, Luca;LaPointe, Nichole E.;Sercel, Alexander J.;Shade, Madeleine F.;Feinstein, Stuart C.;Bowers, Michael T.;Shea, Joan-Emma
• 通讯作者: Shea, Joan-Emma

Amyloid β-protein assembly: The effect of molecular tweezers CLR01 and CLR03.

β-淀粉样蛋白组装：分子镊子 CLR01 和 CLR03 的作用。

• DOI: 10.1021/acs.jpcb.5b00692
• 发表时间: 2015-04-09
• 期刊: JOURNAL OF PHYSICAL CHEMISTRY B
• 影响因子: 3.3
• 作者: Zheng, Xueyun;Liu, Deyu;Klaerner, Frank-Gerrit;Schrader, Thomas;Bitan, Gal;Bowers, Michael T.
• 通讯作者: Bowers, Michael T.

Elucidation of the Aggregation Pathways of Helix-Turn-Helix Peptides: Stabilization at the Turn Region Is Critical for Fibril Formation.

• DOI: 10.1021/acs.biochem.5b00414
• 发表时间: 2015-07-07
• 期刊: Biochemistry
• 影响因子: 2.9
• 作者: Do TD;Chamas A;Zheng X;Barnes A;Chang D;Veldstra T;Takhar H;Dressler N;Trapp B;Miller K;McMahon A;Meredith SC;Shea JE;Lazar Cantrell K;Bowers MT
• 通讯作者: Bowers MT

Amyloid β-Protein Assembly and Alzheimer's Disease: Dodecamers of Aβ42, but Not of Aβ40, Seed Fibril Formation.

• DOI: 10.1021/jacs.5b11913
• 发表时间: 2016-02-17
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Economou NJ;Giammona MJ;Do TD;Zheng X;Teplow DB;Buratto SK;Bowers MT
• 通讯作者: Bowers MT

Ion mobility spectrometry: A personal view of its development at UCSB.

• DOI: 10.1016/j.ijms.2014.06.016
• 发表时间: 2014-09-15
• 期刊: International journal of mass spectrometry
• 影响因子: 1.8
• 作者: Bowers MT