课题基金 / 基金详情

The Genetic and Environmental Etiology of Non-Medical Use of Prescription Drugs

The Genetic and Environmental Etiology of Non-Medical Use of Prescription Drugs
处方药非医疗用途的遗传和环境病因学
批准号:
9306041
负责人:
ERIC G BENOTSCH
金额:
$22.88万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-07-01 至 2019-06-30

项目摘要

项目成果

ERIC G BENOTSCH的其他基金

相似基金

相关文献

中文摘要
翻译
项目总结
英文摘要
Project summary Non-medical use of prescription substances (NMUPS) is the use of a medication without a prescription, in ways other than prescribed, or for the experience or feelings elicited. The picture of NMUPS among young adults is bleak. Each year an estimated 2.4 million North Americans, or ~6,600 initiates per day, use prescription drugs non-medically for the first time, more than one-half are females. NMUPS is highest among young adults aged 18 to 25, with 5.3% reporting current NMUPS. NMUPS is associated with college drop out, worse employment outcomes, sexual victimization, health-jeopardizing behaviors such as driving under the influence, and high-risk sexual behavior, and psychiatric symptoms including suicide. Among adolescents, U.S. college students and young adults, it is also associated with poly-substance use including cocaine, ecstasy, and amphetamine-like substances. More than half of all drug-related emergency room visits in the U.S. can now be linked to NMUPS. NMUPS is a clear threat to public health. Deaths attributable to unintentional drug overdose of opioids and analgesic exceed those for cocaine and heroin, and continue to increase. Moreover, the death toll across all age groups from NMUPS exceeds those for all other illicit substances. Factors driving NMUPS include, but are not limited to, misperceptions about safety, increasing drug availability, along with individual risk factors and motivations. Despite the high prevalence of NMUPS, concomitant death rates, and comorbidity, the basic genetic epidemiology of NMUPS in terms of genetic and environmental risks remains unknown. Without a thorough, empirical understanding of these risk factors, prevention and intervention programs will continue to remain limited. Knowledge of these risks factors and their relation to other substances will also determine whether funding the development of NMUPS-specific diagnostic assessments is also merited. We propose secondary data analyses using two large population-based samples varying by sex, age and ethnicity to address three aims. The first is to describe the patterns of NMUP analgesics and stimulants in two population-based samples of young adults and college-aged students. We will then use basic genetic epidemiological methods to estimate the contribution of genetic and environmental risks in NMUP analgesics and stimulants. Next, advanced genetic epidemiological will be used to estimate the degree of genetic and environmental overlap between NMUP analgesics and stimulants and other licit and illicit substance use. Finally, we determine whether polygenic risk for alcohol, nicotine, cannabis, cocaine, and heroin use and substance use predicts NMUP analgesics and stimulants while examining sex, age and ethnic differences. This knowledge will significantly improve our understanding of the genetic and environmental risks behind the emerging, dangerous trends in NMUPS.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1016/j.drugalcdep.2018.08.012
发表时间: 2018
期刊: Drug and alcohol dependence
影响因子: 4.2
作者: [Tam,CheukChi, Benotsch,EricG, Wang,Xiaolei, Lin,Danhua, Du,Hongfei, Chi,Peilian]
通讯作者: Chi,Peilian
Self-Esteem and Non-Medical Use of Prescription Drugs among College Students: Coping as a Mediator.
大学生的自尊和处方药的非医疗使用:作为调解者的应对。
DOI: 10.1080/10826084.2020.1735441
发表时间: 2020
期刊: Substance use & misuse
影响因子: 2
作者: [Tam,CheukChi, Benotsch,EricG, Li,Xiaoming]
通讯作者: Li,Xiaoming
Sexual enhancement expectancy, non-medical use of prescription drugs, and sexual risk behaviors in college students.
大学生的性增强预期、处方药的非医疗使用和性危险行为。
DOI: 10.1080/08897077.2020.1803177
发表时间: 2021
期刊: Substance abuse
影响因子: 3.5
作者: [Tam,CheukChi, Benotsch,EricG, Li,Xiaoming]
通讯作者: Li,Xiaoming
The Genetic and Environmental Etiology of Non-Medical Use of Prescription Drugs
  • 批准号:
    9182625
  • 项目类别:
  • 资助金额:
    $19.06万
  • 财政年份:
    2016
  • 负责人:
    ERIC G BENOTSCH
  • 依托单位:
HIV Risk Behavior in Men Engaged in Recreational Travel
HIV Risk Behavior in Men Engaged in Recreational Travel
Online Adaptation of HIV Risk-Reduction Interventions
海外基金