The Genetic and Environmental Etiology of Non-Medical Use of Prescription Drugs
处方药非医疗用途的遗传和环境病因学
基本信息
- 批准号:9182625
- 负责人:
- 金额:$ 19.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-07-01 至 2018-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdolescentAgeAlcohol consumptionAlcohol or Other Drugs useAlcoholsAmericanAmphetaminesAnalgesicsAustraliaAutomobile DrivingBasic ScienceBehaviorBiologicalCannabisCaucasiansCessation of lifeClinicalCocaineComorbidityDataData AnalysesDeath RateDependenceDevelopmentDiagnosticDropsDrug PrescriptionsEmergency department visitEmploymentEnvironmental Risk FactorEpidemiologic MethodsEpidemiologyEthnic OriginEthnic groupEtiologyFeelingFemaleFrequenciesFundingGenesGeneticGenetic RiskHallucinogensHealthHeroinHigh PrevalenceIllicit DrugsIndividualInhalant dose formInterventionKnowledgeLinkMeasurementMeasuresMedicalMotivationNicotineNicotine DependenceOpioidOpioid AnalgesicsOutcomeOverdosePatternPharmaceutical PreparationsPrevalencePrevention programPublic HealthReportingRiskRisk FactorsRoleSafetySamplingScience of geneticsSex CharacteristicsStudentsSubstance Use DisorderSuicideTestingTimeTreatment outcomeTwin Multiple BirthVisitadolescent substance useage differenceage groupagedalcohol riskattributable mortalitycocaine usecollegecravingdriving under influenceecstasyethnic differenceexperiencegenetic epidemiologygenetic risk factorgenome wide association studyhigh risk sexual behaviorimprovedintervention programmarijuana use disordernon-drugpopulation basedpsychiatric symptompsychosocialsedativesexsexual victimizationsubstance use preventiontrenduniversity studentyoung adult
项目摘要
Project summary
Non-medical use of prescription substances (NMUPS) is the use of a medication without a prescription, in
ways other than prescribed, or for the experience or feelings elicited. The picture of NMUPS among young
adults is bleak. Each year an estimated 2.4 million North Americans, or ~6,600 initiates per day, use
prescription drugs non-medically for the first time, more than one-half are females. NMUPS is highest among
young adults aged 18 to 25, with 5.3% reporting current NMUPS. NMUPS is associated with college drop out,
worse employment outcomes, sexual victimization, health-jeopardizing behaviors such as driving under the
influence, and high-risk sexual behavior, and psychiatric symptoms including suicide. Among adolescents, U.S.
college students and young adults, it is also associated with poly-substance use including cocaine, ecstasy,
and amphetamine-like substances. More than half of all drug-related emergency room visits in the U.S. can
now be linked to NMUPS. NMUPS is a clear threat to public health. Deaths attributable to unintentional drug
overdose of opioids and analgesic exceed those for cocaine and heroin, and continue to increase. Moreover,
the death toll across all age groups from NMUPS exceeds those for all other illicit substances.
Factors driving NMUPS include, but are not limited to, misperceptions about safety, increasing drug
availability, along with individual risk factors and motivations. Despite the high prevalence of NMUPS,
concomitant death rates, and comorbidity, the basic genetic epidemiology of NMUPS in terms of genetic and
environmental risks remains unknown. Without a thorough, empirical understanding of these risk factors,
prevention and intervention programs will continue to remain limited. Knowledge of these risks factors and their
relation to other substances will also determine whether funding the development of NMUPS-specific
diagnostic assessments is also merited.
We propose secondary data analyses using two large population-based samples varying by sex, age and
ethnicity to address three aims. The first is to describe the patterns of NMUP analgesics and stimulants in two
population-based samples of young adults and college-aged students. We will then use basic genetic
epidemiological methods to estimate the contribution of genetic and environmental risks in NMUP analgesics
and stimulants. Next, advanced genetic epidemiological will be used to estimate the degree of genetic and
environmental overlap between NMUP analgesics and stimulants and other licit and illicit substance use.
Finally, we determine whether polygenic risk for alcohol, nicotine, cannabis, cocaine, and heroin use and
substance use predicts NMUP analgesics and stimulants while examining sex, age and ethnic differences.
This knowledge will significantly improve our understanding of the genetic and environmental risks behind the
emerging, dangerous trends in NMUPS.
项目摘要
处方物质的非医疗使用(NMUPS)是指在没有处方的情况下使用药物,
除规定的方式外,或为引起的经验或感受。NMUPS在年轻人中的形象
成年人是暗淡的。每年估计有240万北美人,或每天约6,600名同修,
首次使用非医疗处方药的妇女超过一半。NMUPS是其中最高的
18至25岁的年轻人,5.3%的人报告目前的NMUPS。NMUPS与大学辍学有关,
更糟糕的就业结果,性受害,危害健康的行为,如驾驶下,
影响,和高风险的性行为,和精神症状,包括自杀。在青少年中,美国
大学生和年轻人,它也与多种物质的使用有关,包括可卡因,摇头丸,
和安非他明类物质在美国,超过一半的与毒品有关的急诊室就诊可以
现在已经连接到NMUPS。NMUPS对公众健康构成明显威胁。意外吸毒致死
阿片类药物和止痛药过量超过可卡因和海洛因,并继续增加。此外,委员会认为,
所有年龄组的NMUPS死亡人数超过了所有其他非法物质。
推动NMUPS的因素包括但不限于对安全性的误解,增加药物
可用性,沿着个人风险因素和动机。尽管NMUPS的患病率很高,
伴随死亡率和并发症,NMUPS在遗传和
环境风险仍然未知。如果没有对这些风险因素进行彻底的、经验性的了解,
预防和干预方案将继续受到限制。了解这些风险因素及其
与其他物质的关系也将决定是否资助开发特定的NMUPS
诊断评估也是值得的。
我们建议使用两个大的基于人群的样本进行二次数据分析,这些样本按性别、年龄和
以民族为中心,实现三个目标。第一个是描述两种NMUP镇痛药和兴奋剂的模式
以年轻人和大学生为基础的人口样本。然后我们将使用基本的基因
流行病学方法估计NMUP镇痛药中遗传和环境风险的贡献
和兴奋剂。下一步,先进的遗传流行病学将用于估计遗传和
NMUP镇痛剂和兴奋剂与其他合法和非法物质使用之间的环境重叠。
最后,我们确定酒精、尼古丁、大麻、可卡因和海洛因使用的多基因风险,
物质使用预测NMUP镇痛药和兴奋剂,同时检查性别,年龄和种族差异。
这些知识将大大提高我们对遗传和环境风险的理解,
新出现的危险趋势。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ERIC G BENOTSCH其他文献
ERIC G BENOTSCH的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ERIC G BENOTSCH', 18)}}的其他基金
The Genetic and Environmental Etiology of Non-Medical Use of Prescription Drugs
处方药非医疗用途的遗传和环境病因学
- 批准号:
9306041 - 财政年份:2016
- 资助金额:
$ 19.06万 - 项目类别:
HIV Risk Behavior in Men Engaged in Recreational Travel
从事休闲旅行的男性的艾滋病毒风险行为
- 批准号:
7167314 - 财政年份:2006
- 资助金额:
$ 19.06万 - 项目类别:
HIV Risk Behavior in Men Engaged in Recreational Travel
从事休闲旅行的男性的艾滋病毒风险行为
- 批准号:
7268027 - 财政年份:2006
- 资助金额:
$ 19.06万 - 项目类别:
Online Adaptation of HIV Risk-Reduction Interventions
艾滋病毒风险降低干预措施的在线调整
- 批准号:
7005851 - 财政年份:2005
- 资助金额:
$ 19.06万 - 项目类别:
Online Adaptation of HIV Risk-Reduction Interventions
艾滋病毒风险降低干预措施的在线调整
- 批准号:
7275318 - 财政年份:2005
- 资助金额:
$ 19.06万 - 项目类别:
Online Adaptation of HIV Risk-Reduction Interventions
艾滋病毒风险降低干预措施的在线调整
- 批准号:
7117677 - 财政年份:2005
- 资助金额:
$ 19.06万 - 项目类别:
相似海外基金
Developmental trajectories of brain rhythm dynamics in healthy adolescent rats: oscillatory network reconfigurations at the vulnerable age of schizophrenia prodrome
健康青少年大鼠脑节律动态的发育轨迹:精神分裂症前驱症状脆弱年龄的振荡网络重构
- 批准号:
10646175 - 财政年份:2022
- 资助金额:
$ 19.06万 - 项目类别:
Developmental trajectories of brain rhythm dynamics in healthy adolescent rats: oscillatory network reconfigurations at the vulnerable age of schizophrenia prodrome
健康青少年大鼠脑节律动态的发育轨迹:精神分裂症前驱症状脆弱年龄的振荡网络重构
- 批准号:
10373688 - 财政年份:2022
- 资助金额:
$ 19.06万 - 项目类别:
Quantifying Real-world Effectiveness of Mental Health Interventions for Suicide Prevention in At-risk Adolescent and Transitional Age Youth
量化高危青少年和过渡时期青年心理健康干预措施预防自杀的现实有效性
- 批准号:
10610840 - 财政年份:2021
- 资助金额:
$ 19.06万 - 项目类别:
Quantifying Real-world Effectiveness of Mental Health Interventions for Suicide Prevention in At-risk Adolescent and Transitional Age Youth
量化高危青少年和过渡时期青年心理健康干预措施预防自杀的现实有效性
- 批准号:
10205663 - 财政年份:2021
- 资助金额:
$ 19.06万 - 项目类别:
Quantifying Real-world Effectiveness of Mental Health Interventions for Suicide Prevention in At-risk Adolescent and Transitional Age Youth
量化高危青少年和过渡时期青年心理健康干预措施预防自杀的现实有效性
- 批准号:
10394352 - 财政年份:2021
- 资助金额:
$ 19.06万 - 项目类别:
A Centre of Research Excellence in Adolescent Health: Making health services work for adolescents in a digital age
青少年健康卓越研究中心:让健康服务为数字时代的青少年服务
- 批准号:
nhmrc : GNT1134894 - 财政年份:2017
- 资助金额:
$ 19.06万 - 项目类别:
Centres of Research Excellence
A Centre of Research Excellence in Adolescent Health: Making health services work for adolescents in a digital age
青少年健康卓越研究中心:让健康服务为数字时代的青少年服务
- 批准号:
nhmrc : 1134894 - 财政年份:2017
- 资助金额:
$ 19.06万 - 项目类别:
Centres of Research Excellence
Effects of delaying age of onset of binge drinking on adolescent brain development: A proposal to add neuroimaing measures to the CO-Venture Trial.
延迟酗酒的发病年龄对青少年大脑发育的影响:在 CO-Venture 试验中添加神经影像测量的建议。
- 批准号:
267251 - 财政年份:2012
- 资助金额:
$ 19.06万 - 项目类别:
Operating Grants
Partner Age Discordance and HIV Risk Behaviors in Adolescent Girls (Sexual RP)
青春期女孩的伴侣年龄不一致和艾滋病毒风险行为(性 RP)
- 批准号:
7556355 - 财政年份:2007
- 资助金额:
$ 19.06万 - 项目类别:
Partner Age Discordance and HIV Risk Behaviors in Adolescent Girls (Sexual RP)
青春期女孩的伴侣年龄不一致和艾滋病毒风险行为(性 RP)
- 批准号:
7714365 - 财政年份:2007
- 资助金额:
$ 19.06万 - 项目类别: