CENTER FOR SKELETAL RESEARCH

骨骼研究中心

• 批准号: 9285601
• 负责人: HENRY M. KRONENBERG
• 金额: $ 69.6万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9285601
• 关键词: Advisory Committees; Biology; Bone Diseases; Boston; Clinical Investigator; Collaborations; Communication; Communities; Complement; Core Facility; Country; Data; Dental Schools; Development; Diagnosis; Discipline; Endocrine; Feedback; Fostering; Funding; General Hospitals; Goals; Grant; Institution; Laboratories; Lead; Massachusetts; Medicine; Mentors; Osteoporosis; Phenotype; Research; Research Personnel; Science; Scientist; Series; Services; Signal Transduction; Suggestion; Techniques; Time; Work; bone; bone cell; design; environmental enrichment for laboratory animals; experience; innovation; meetings; novel; programs; public health relevance; skeletal; skeletal disorder

DESCRIPTION (provided by applicant): The overall goal of the Center for Skeletal Research is to foster Interdisciplinary and collaborative work that leads to a deeper understanding of skeletal biology, in a way that can lead to new ways of diagnosing and treating skeletal diseases. The Center will build upon and expand a community of bone scientists in the Endocrine Unit and other Units at the Massachusetts General Hospital, the Harvard School of Dental Medicine, and other Harvard-associated departments and institutions. This group has already defined itself through a network of collaborations and a monthly seminar series sponsored jointly by the MGH Endocrine Unit and the Harvard School of Dental Medicine, and includes bone scientists from multiple Harvard institutions. These scientists are diverse, including clinical investigators and laboratory investigators using a broad array of approaches from multiple disciplines. The mechanisms that the Center will use to accomplish its goal include Core Facilities, a Pilot and Feasibility Grant Program, and a seminar series. The Cores will include a Skeletal Phenotyping Core and a Bone Cells and Signaling Core. These Cores will emphasize the development of new techniques that can drive the science of Center investigators, as well as the provision of expert and efficient service. The goal of the Pilot and Feasibility Grant Program will be to allow young investigators to develop sufficient data to obtain their own grants; in that context, a vigorous mentoring program will complement the funding. The seminar series will foster collaboration and communication among Center scientists. Young investigators will present current data in some sessions, while others will bring in distinguished bone scientists from outside of Boston to enrich the environment. This series will also include presentations by Core Directors that explain the techniques used in the Cores and will provide a forum for feedback by Center investigators that will include suggestions for novel Core services. An Administrative Core will assure effective functioning of these activities through regular meetings of Core Directors that, four times a year, will also involve meeting with an Advisory Committee made up of senior investigators within the Center, as well as investigators from elsewhere with relevant experience leading similar programs. The Center will be committed to sharing its innovations with the broader community of bone scientists across the country.

描述（由申请人提供）：骨骼研究中心的总体目标是促进跨学科和协作工作，从而更深入地了解骨骼生物学，从而找到诊断和治疗骨骼疾病的新方法。该中心将在马萨诸塞州总医院、哈佛大学牙科医学院和其他哈佛大学相关部门和机构的内分泌部门和其他部门建立并扩大骨骼科学家社区。这个小组已经通过合作网络和由MGH内分泌部门和哈佛大学牙科医学院联合主办的每月系列研讨会来定义自己，其中包括来自多个哈佛大学机构的骨骼科学家。这些科学家是多种多样的，包括临床研究人员和实验室研究人员，他们使用来自多个学科的广泛方法。该中心为实现其目标将使用的机制包括核心设施、试点和可行性资助计划以及一系列研讨会。这些核心将包括一个骨骼表型核心和一个骨细胞和信号核心。这些核心将强调新技术的发展，可以推动中心研究人员的科学，以及提供专家和高效的服务。试点和可行性资助计划的目标将是允许年轻的研究人员开发足够的数据，以获得