CENTER FOR SKELETAL RESEARCH

描述（由申请人提供）：该中心的总体目标是促进跨学科和协作的工作，导致骨骼生物学的更深入的了解，在某种程度上，可以导致诊断和治疗骨骼疾病的新方法。该中心将建立并扩大马萨诸塞州总医院内分泌科和其他科室、哈佛牙科医学院以及其他哈佛相关部门和机构的骨骼科学家社区。这个小组已经通过合作网络和每月由MGH内分泌单位和哈佛牙科医学院联合主办的系列研讨会来定义自己，其中包括来自多个哈佛机构的骨骼科学家。这些科学家是多样化的，包括临床研究人员和实验室研究人员，他们使用来自多个学科的广泛方法。该中心将用于实现其目标的机制包括核心设施，试点和可行性资助计划，以及一系列研讨会。核心将包括一个Skeleton表型核心和一个骨细胞和信号核心。这些核心将强调开发新技术，以推动中心调查人员的科学发展，以及提供专业和高效的服务。试点和可行性资助计划的目标是让年轻的研究人员开发足够的数据， 他们自己的赠款;在这种情况下，一个有力的指导方案将补充资金。该系列研讨会将促进中心科学家之间的合作和交流。年轻的研究人员将在一些会议上介绍当前的数据，而其他人将从波士顿以外的著名骨骼科学家，以丰富环境。该系列还将包括核心主任的演讲，解释核心中使用的技术，并将为中心调查人员提供一个反馈论坛，其中包括对新核心服务的建议。一个行政核心将通过核心主任的定期会议确保这些活动的有效运作，每年四次，还将包括与咨询委员会的会议，该委员会由中心内的高级调查员以及来自其他地方的具有领导类似项目相关经验的调查员组成。该中心将致力于与全国更广泛的骨骼科学家社区分享其创新成果。

DESCRIPTION (provided by applicant): The overall goal of the Center for Skeletal Research is to foster Interdisciplinary and collaborative work that leads to a deeper understanding of skeletal biology, in a way that can lead to new ways of diagnosing and treating skeletal diseases. The Center will build upon and expand a community of bone scientists in the Endocrine Unit and other Units at the Massachusetts General Hospital, the Harvard School of Dental Medicine, and other Harvard-associated departments and institutions. This group has already defined itself through a network of collaborations and a monthly seminar series sponsored jointly by the MGH Endocrine Unit and the Harvard School of Dental Medicine, and includes bone scientists from multiple Harvard institutions. These scientists are diverse, including clinical investigators and laboratory investigators using a broad array of approaches from multiple disciplines. The mechanisms that the Center will use to accomplish its goal include Core Facilities, a Pilot and Feasibility Grant Program, and a seminar series. The Cores will include a Skeletal Phenotyping Core and a Bone Cells and Signaling Core. These Cores will emphasize the development of new techniques that can drive the science of Center investigators, as well as the provision of expert and efficient service. The goal of the Pilot and Feasibility Grant Program will be to allow young investigators to develop sufficient data to obtain their own grants; in that context, a vigorous mentoring program will complement the funding. The seminar series will foster collaboration and communication among Center scientists. Young investigators will present current data in some sessions, while others will bring in distinguished bone scientists from outside of Boston to enrich the environment. This series will also include presentations by Core Directors that explain the techniques used in the Cores and will provide a forum for feedback by Center investigators that will include suggestions for novel Core services. An Administrative Core will assure effective functioning of these activities through regular meetings of Core Directors that, four times a year, will also involve meeting with an Advisory Committee made up of senior investigators within the Center, as well as investigators from elsewhere with relevant experience leading similar programs. The Center will be committed to sharing its innovations with the broader community of bone scientists across the country.