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Columbia/Cornell/Harlem Hospital Precision Medicine Initiative HPO

哥伦比亚/康奈尔/哈莱姆医院精准医学计划 HPO

基本信息

批准号：
9525197
负责人：
ALI G GHARAVI
金额：
$ 212.9万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-06 至 2018-03-23
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9525197
关键词：
Academic Medical Centers Address Adult Affect Area Blood Blood specimen Car Phone Caring Characteristics Childhood Cities Clinical Clinical Data Clinical Research Collaborations Collection Communities Data Data Collection Devices Disease Educational Materials Electronic Health Record Enrollment Ensure Environment Epidemiology Feedback Genetic Research Genomics Goals Grant Health Personnel Health care facility Health system Healthcare Hospitals Human Human Genetics Logistics Longevity Medical center Medicine Monitor Names Network Infrastructure New York New York City PMI cohort Participant Pathology Patients Phase Population Precision Medicine Initiative Presbyterian Church Process Public Health Quality Control Recording of previous events Recruitment Activity Research Research Infrastructure Research Personnel Role Saliva Sampling Standardization Structure Surveys System Tablets Time United States National Institutes of Health Urine Work base biobank clinical care clinical phenotype cohort data management digital epidemiological model ethnic diversity experience genomic data graphical user interface improved mHealth meetings member novel outreach phenotypic data precision medicine programs prospective racial and ethnic research study socioeconomics volunteer

项目摘要

Summary Our project brings together the large NewYork-Presbyterian (NYP) health system with its affiliated Medical Centers – Weill Cornell Medicine (WCM) and the Columbia University Medical Center (CUMC), as well as the CUMC partner, Harlem Hospital (HH), a community-based public health facility, to achieve the aims of the national Precision Medicine Initiative (PMI). We will leverage our pre-existing Hospital Network Infrastructure to enroll at least 150,000 patients over 5 years from our ethnically diverse New York City population into a cohort named the NYC Precision Medicine Initiative cohort (NYC-PMI). We will collect and pre-process appropriate biospecimens from all participants including blood sample, saliva sample, and a urine sample. We will extract all electronic health record data for our participants, and provide standardized physical exam, survey data and all other phenotypic data as required for the national cohort to ensure harmonization with PMI data standards. Our HPO will also perform real-time epidemiological modeling of the characteristics of the participants enrolled and adjust enrollment to meet the goals of the National Cohort. Finally, we will actively engage community members, leaders, and organizations throughout New York City to ensure that the aims of the National PMI are appreciated by the broader community and that participants understand the initiative, its benefits and the importance of remaining engaged through their lifespan. We will bring into the national study a demographically diverse cohort that will feature a broad range of rare and common clinical disorders for which we provide expert care at our HPO. Thus, we will not only enroll the requisite number of participants and contribute diversity to the national cohort, but we will provide the clinical and research expertise necessary to make effective use of genomic data. We have long-standing experience with community engagement in research, and have long-standing experience collaboratively in cooperative NIH grant activities to ensure that the overall scientific aims of the PMI are achieved.

摘要我们的项目将大型纽约长老会(NYP)医疗系统及其附属医疗系统结合在一起中心-威尔康奈尔医学中心(WCM)和哥伦比亚大学医学中心(CUMC)，以及社区公共卫生机构哈莱姆医院(HH)的CUMC合作伙伴，以实现国家精准医学倡议(PMI)。我们将利用我们现有的医院网络基础设施来在5年内从纽约市不同种族的人口中招募至少15万名患者加入队列被命名为纽约市精准医学倡议队列(NYC-PMI)。我们将收集和处理适当的来自所有参与者的生物样本，包括血液样本、唾液样本和尿样。我们将提取为参与者提供所有电子健康记录数据，并提供标准化的体检、调查数据和国家队列所需的所有其他表型数据，以确保与采购经理人指数数据标准相一致。我们的卫生组织还将对登记的参与者的特征进行实时流行病学建模并调整招生人数，以满足国家队列的目标。最后，我们将积极参与社区活动纽约市的成员、领导人和组织，以确保全国采购经理人指数的目标是受到更广泛的社区的赞赏，参与者了解该倡议、其好处和在他们的一生中保持投入的重要性。我们将把人口结构多样化的队列纳入国家研究，这些队列将具有广泛的稀有和常见的临床疾病，我们在我们的HPO提供专家护理。因此，我们不仅将招收所需的参与者数量，并为国家队列做出贡献，但我们将提供临床以及有效利用基因组数据所需的研究专业知识。我们有悠久的经验社区参与研究，并在合作方面有长期的合作经验 NIH赠款活动，以确保实现PMI的总体科学目标。