Core C: Tissue and Imaging Core

组织和成像核心（核心C）旨在提高科学目标和成本- 通过以下方式提高项目的有效性： 1)通过在组织准备中提供帮助， 2)通过用标准和新方法定量动脉粥样硬化，包括主动脉窦，整个主动脉正面， 头臂动脉和纵向主动脉弓（“甘蔗”）分析 3)通过为研究者提供基于病理学的分析技术的专业知识， 染色、免疫组织化学和免疫荧光，以及 4)通过为研究人员提供更先进的，基于组织的分析技术，包括多种 相同组织切片的染色、数字去卷积显微术、激光捕获显微切割和 电镜集中和标准化计划，组织收集和分析方法， 一个单一的、集成的核心将增加获得可靠结果的可能性， 发展这些领域技术专门知识的项目。此外，在一个单一的， 集成的核心将允许以一种促进项目的方式将结果提供给每个项目 交互.

The Tissue and Imaging Core (Core C) is designed to enhance the scientific objectives and cost- effectiveness of the Program Project in the following ways: 1) by providing assistance in tissue preparation 2) by quantifying atherosclerosis by standard and novel methods, including aortic sinus, whole aorta en face, brachiocephalic artery and longitudinal aortic arch (“candy cane”) analyses 3) by providing investigators with expertise in pathology-based analytical techniques such as histological staining, immunohistochemistry and immunofluorescence, and 4) by providing investigators with more advanced, tissue-based analytical techniques, including multiple staining of the same tissue section, digital deconvolution microscopy, laser capture microdissection and electron microscopy. Centralizing and standardizing planning, tissue collection and methods of analyses in a single, integrated Core will increase the likelihood of obtaining reliable results and not compel individual Projects to develop technical expertise in these areas. Further, carrying out these studies in a single, integrated Core will allow the results to be made available to each project in a way that facilitates Project interactions.