Pathology (PSR)

病理学（PSR）

• 批准号: 9204742
• 负责人: Gregory James Tsongalis
• 金额: $ 12.03万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9204742
• 关键词: Accreditation; Algorithms; Biological Markers; Blood Component Removal; CLIA certified; Cancer Center Support Grant; Cancer Control Research Program; Cancer Immunology Science; Cells; Clinical; Clinical Research; Consultations; Cytogenetic Analysis; Data Analyses; Environment; Faculty; Genotype; Goals; Histologic; Histology; Image Analysis; Individual; Laboratories; Malignant Neoplasms; Molecular; Molecular Analysis; Norris Cotton Cancer Center; Nurses; Pathology; Physicians; Postdoctoral Fellow; Protocols documentation; Radiobiology; Research Personnel; Research Project Grants; Resource Sharing; Scientist; Services; Specialist; Specimen; Staining method; Stains; Standardization; Testing; Therapeutic; Tissue Microarray; Tissues; Translational Research; Work; biobank; cancer epidemiology; cancer imaging; cancer immunotherapy; design; experience; human tissue; member; molecular pathology; next generation sequencing; preclinical study; quantitative imaging; service utilization

Project Summary/Abstract: Pathology Shared Resource (PSR) The Pathology Shared Resource (PSR) was created to provide Norris Cotton Cancer Center (NCCC) investigators from different backgrounds (e.g., physicians, basic scientists, diagnosticians) access to a CLIA- certified, CAP-accredited facility with standardized laboratory protocols for histologic, quantitative imaging and molecular analysis. The ultimate goal of the PSR is to provide NCCC investigators with state-of-the-art technical and professional support leading to quality results for clinical and pre-clinical studies. The PSR has consolidated institutional expertise and experience by combining responsibility for providing for and supporting both clinical and research utilization of these services. The PSR supports human tissue and cell procurement/acquisition (i.e., handling, storage, distribution and biobanking); histology and immunohistochemical analysis; molecular pathology analysis (i.e., genotyping, next-generation sequencing, quantitative PCR, tissue microarrays; cell processing services); and cytogenetics analysis. The PSR is directed by Dr. Gregory Tsongalis, who oversees a staff of 12 that includes two Research Associates, two Histotechnologists, an Apheresis Nurse, and seven additional technical specialists. The PSR is organized to identify as early as possible the needs of researchers in developing and supporting their translational research project, providing them with technical support and consultation. Further, many Pathology faculty become involved in collaborating on individual research projects by reviewing proposals, selecting appropriate tissues, designing IHC staining and molecular testing algorithms, creating tissue arrays, suggesting alternative biomarker testing, and scoring IHC expression levels. The PSR has supported NCCC Members in each of the six Research Programs: Cancer Control (2 members), Cancer Epidemiology (6 members), Cancer Mechanisms (12 members), Molecular Therapeutics (27 members), Cancer Imaging & Radiobiology (7 members), and Immunology & Cancer Immunotherapy (12 members).

项目摘要/摘要：病理学共享资源（PSR） 病理学共享资源（PSR）的创建是为了提供诺里斯棉花癌症中心（NCCC） 来自不同背景的调查人员（例如，医生、基础科学家、诊断医生）获得CLIA- 经过认证的CAP认证机构，具有组织学、定量成像和 分子分析PSR的最终目标是为NCCC调查人员提供最先进的 技术和专业支持，为临床和临床前研究提供高质量的结果。PSR已 通过将提供和支持的责任相结合， 临床和研究使用这些服务。PSR支持人体组织和细胞 采购/获取（即，处理、储存、分配和生物库）;组织学和 免疫组织化学分析;分子病理学分析（即，基因分型、下一代测序、 定量PCR、组织微阵列;细胞处理服务）;和细胞遗传学分析。PSR是针对 格雷戈里·聪格斯博士，他负责监督12名员工，其中包括两名研究助理，两名 组织技术专家、一名单采护士和另外七名技术专家。PSR的组织目的是 尽早确定研究人员在发展和支持其翻译研究方面的需求 项目，为他们提供技术支持和咨询。此外，许多病理学教师成为 通过审查提案，选择适当的组织， 设计IHC染色和分子检测算法，创建组织阵列，提出替代方案 生物标志物测试和对IHC表达水平进行评分。PSR支持NCCC成员在每一个 六个研究项目：癌症控制（2名成员），癌症流行病学（6名成员），癌症 分子机制（12名成员），分子治疗学（27名成员），癌症成像与放射生物学（7名成员） 免疫学与癌症免疫疗法（Immunology & Cancer Immunotherapy，12名成员）。