Pathology (PSR)

项目摘要/摘要：病理共享资源(PSR) 病理共享资源(PSR)是为了向诺里斯棉花癌症中心(NCCC)提供 来自不同背景的研究人员(例如，医生、基础科学家、诊断学家)访问CLIA- 经过CAP认证的设施，具有标准化的实验室方案，用于组织学、定量成像和 分子分析。PSR的最终目标是为NCCC调查人员提供最先进的 技术和专业支持，为临床和临床前研究提供高质量的结果。PSR有 通过将提供和支助的责任结合起来巩固机构专门知识和经验 临床和研究利用这些服务。PSR支持人体组织和细胞 采购/购置(即处理、储存、分配和生物库)；组织学和 免疫组织化学分析；分子病理学分析(即基因分型、下一代测序、 定量聚合酶链式反应、组织微阵列、细胞处理服务)和细胞遗传学分析。PSR是定向的 由格雷戈里·特松加里斯博士撰写，他管理着12名员工，其中包括两名研究助理，两名 组织技术学家，一名止血护士，以及另外七名技术专家。PSR的组织是为了 尽早确定研究人员在开发和支持其翻译研究方面的需求 项目，为他们提供技术支持和咨询。此外，许多病理学教员变得 参与单个研究项目的合作，通过审查提案，选择适当的组织， 设计IHC染色和分子测试算法，创建组织阵列，提出替代方案 生物标记物检测，并对IHC表达水平进行评分。PSR支持NCCC成员在每个 六个研究项目：癌症控制(2名成员)、癌症流行病学(6名成员)、癌症 机制(12名成员)、分子治疗学(27名成员)、肿瘤影像和放射生物学(7名 以及免疫学和癌症免疫疗法(12名成员)。

Project Summary/Abstract: Pathology Shared Resource (PSR) The Pathology Shared Resource (PSR) was created to provide Norris Cotton Cancer Center (NCCC) investigators from different backgrounds (e.g., physicians, basic scientists, diagnosticians) access to a CLIA- certified, CAP-accredited facility with standardized laboratory protocols for histologic, quantitative imaging and molecular analysis. The ultimate goal of the PSR is to provide NCCC investigators with state-of-the-art technical and professional support leading to quality results for clinical and pre-clinical studies. The PSR has consolidated institutional expertise and experience by combining responsibility for providing for and supporting both clinical and research utilization of these services. The PSR supports human tissue and cell procurement/acquisition (i.e., handling, storage, distribution and biobanking); histology and immunohistochemical analysis; molecular pathology analysis (i.e., genotyping, next-generation sequencing, quantitative PCR, tissue microarrays; cell processing services); and cytogenetics analysis. The PSR is directed by Dr. Gregory Tsongalis, who oversees a staff of 12 that includes two Research Associates, two Histotechnologists, an Apheresis Nurse, and seven additional technical specialists. The PSR is organized to identify as early as possible the needs of researchers in developing and supporting their translational research project, providing them with technical support and consultation. Further, many Pathology faculty become involved in collaborating on individual research projects by reviewing proposals, selecting appropriate tissues, designing IHC staining and molecular testing algorithms, creating tissue arrays, suggesting alternative biomarker testing, and scoring IHC expression levels. The PSR has supported NCCC Members in each of the six Research Programs: Cancer Control (2 members), Cancer Epidemiology (6 members), Cancer Mechanisms (12 members), Molecular Therapeutics (27 members), Cancer Imaging & Radiobiology (7 members), and Immunology & Cancer Immunotherapy (12 members).