Prosthetic System for Large-Scale Recording and Manipulation of Neural Circuit Activity in Non-Human Primates

用于大规模记录和操纵非人类灵长类动物神经回路活动的假体系统

• 批准号: 9410278
• 负责人: Albert Baldwin Goodell
• 金额: $ 23.24万
• 依托单位: GRAYMATTER RESEARCH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9410278
• 关键词: Anatomy; Animal Model; Area; BRAIN initiative; Behavior; Brain; Brain region; Cephalic; Chronic; Cognition; Cognition Disorders; Cognitive; Complex; Craniotomy; Custom; Devices; Diagnosis; Electrophysiology (science); Excision; Failure; Finite Element Analysis; Future; Generations; Head; Human; Implant; Individual; Infection; Location; MRI Scans; Magnetic Resonance Imaging; Measures; Mediating; Mental disorders; Methods; Modeling; Monkeys; Neurons; Operative Surgical Procedures; Outcomes Research; Performance; Pharmacology; Phase; Plasticizers; Printing; Procedures; Prosthesis; Research; Research Personnel; Resolution; Silicon; Site; Stress Tests; Structure; Surface; System; Technology; Testing; base; biomaterial compatibility; bone; cognitive function; cognitive task; cost; cranium; design; flexibility; implantation; in vivo; microstimulation; neural circuit; neural prosthesis; neuromechanism; next generation; nonhuman primate; novel; optogenetics; performance tests; prototype; reconstruction; relating to nervous system; sample fixation; seal; virtual

The fundamental objective of the BRAIN Initiative is to understand how dynamic activity in distributed neural circuits mediates human cognitive behavior. The non-human primate (NHP) is a key animal model in this effort, due to the close similarities of its brain to that of humans and its ability to perform complex cognitive tasks. However, developing and testing novel hypotheses for how neural circuit activity in NHPs mediates cognitive function is severely constrained by several technical limitations. We propose to design, build, and test a “next generation” cranially-mounted prosthetic appliance that can be configured for individual monkeys and tailored to provide optimal recording coverage for virtually any experimental plan. The appliance will be designed using anatomical reconstructions of the brain and skull from high resolution MRI scans. Appliances will incorporate an integrated head holder system, mount accurately and easily onto the cranial surface, be MRI-compatible, and include hermetically sealed access ports that enable semi-chronic implantation (and easy removal) of multiple modular devices for large-scale electrophysiology and neural circuit manipulation. In specific aim 1, we will design, build, and bench test an MRI-compatible appliance that can be custom fit to the cranium of an individual monkey. In specific aim 2, we will conduct an in vivo test of the performance of the cranial appliance in two NHPs to evaluate its overall feasibility for future use. The outcome of this research has the potential to transform the way large-scale electrophysiological studies are conducted in NHPs. By alleviating the difficulties in measuring and manipulating large-scale neural circuits, this approach will enable more researchers to greatly expand their scope of inquiry, leading to rapid progress in understanding cognitive brain function.

BRAIN计划的基本目标是了解动态活动是如何分布的