Genetics of African American Type 2 Diabetes

非裔美国人2型糖尿病的遗传学研究 项目总结： 2型糖尿病(T2D)在美国非常流行，在少数族裔人群中的患病率更高(9- 13.2%)，而非西班牙裔白人(7.6%)。使用基因组的大型多血统联盟的努力- 广谱关联研究方法已经成功地识别了大量的遗传变异 与T2D相关联。然而，大多数疾病的遗传性仍然无法解释和识别 对各自因果位置的描述是有限的。对于非洲裔美国人来说尤其如此，重点是 在这一应用中，引领了对2型糖尿病遗传学的基因探索。建立在我们的 在非洲2型糖尿病的荟萃分析中建立非洲裔美国人中最大的GWAS 美国(媒体)财团和其他财团在T2D和相关特征方面的持续合作，这 该项目旨在将基因组学、代谢组学和转录组学的综合表型组学分析应用于油井- 表征样品以实现以下具体目标。目标1：基准线和基准线的综合分析 动态血糖稳态特性及功能变异和靶基因的基因组学鉴定 和新陈代谢组学。目标2：整合基因组学、代谢组学和转录组学以鉴定功能 T2D的变异和靶基因。目标3：整合功能注释、跨海峡关联和 基因-基因/基因环境互作精细定位T2D相关基因座并发现非洲新基因座 美国人和跨国血统的GWA。

Genetics of African American Type 2 Diabetes Project Summary: Type 2 diabetes (T2D) is highly prevalent in the US with higher prevalence in the minority populations (9- 13.2%) as compared to non-Hispanic whites (7.6%). Efforts from large multi-ancestry consortia using genome- wide association studies (GWAS) approaches have successfully identified a large number of genetic variants associated with T2D. However, the majority of disease heritability remains unexplained and identification and characterization of the respective causal loci is limited. This is especially true for African Americans, the focus of this application, in which have led genetic exploration of type 2 diabetes genetics. Building on our establishment of the largest GWAS in African Americans in the Meta-analysis of Type 2 Diabetes in African Americans (MEDIA) Consortium and ongoing collaborations with other consortia on T2D and related traits, this project aims to use integrative phenomics analyses of genomics, metabolomics and transcriptomics in well- characterized samples to achieve the following specific aims. Aim 1: GWAS meta-analysis of baseline and dynamic glucose homeostasis traits and identification of functional variants and target genes using genomics and metabolomics. Aim 2: Integration of genomics, metabolomics and transcriptomics to identify functional variants and target genes for T2D. Aim 3: Integration of functional annotations, cross-trait associations and gene-gene/gene environment interactions to fine map T2D related loci and discover novel loci in African American and trans-ancestry GWAS.