Genetics of African American Type 2 Diabetes

非裔美国人 2 型糖尿病的遗传学

• 批准号: 9447477
• 负责人: Maggie Ng
• 金额: $ 61.3万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9447477
• 关键词: African American; Applications Grants; Beta Cell; Biological; Body mass index; Candidate Disease Gene; Collaborations; Collection; Complement; DNA; Data; Data Set; Databases; Disease; European; Fasting; Functional disorder; Gene Targeting; Genes; Genetic; Genetic Models; Genetic Risk; Genome; Genomics; Genotype; Genotype-Tissue Expression Project; Grant; Haplotypes; Heritability; High Prevalence; Hispanics; Individual; Insulin; Insulin Resistance; Joints; Linkage Disequilibrium; Maps; Meta-Analysis; Methods; Minority; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Obesity; Pathogenicity; Pathway interactions; Population; Prevention; Recruitment Activity; Research Design; Rest; Role; Sampling; Study Subject; Testing; Transcript; Variant; Waist-Hip Ratio; Work; biobank; blood glucose regulation; density; diabetes mellitus genetics; diabetes risk; exome sequencing; fasting glucose; forest; gene environment interaction; genetic variant; genome wide association study; genome-wide; genome-wide analysis; improved; insight; insulin secretion; intravenous glucose tolerance test; metabolic profile; metabolome; metabolomics; non-diabetic; novel; phase 1 study; phase 2 study; phenomics; pleiotropism; reference genome; statistics; trait; transcriptome; transcriptomics

Genetics of African American Type 2 Diabetes Project Summary: Type 2 diabetes (T2D) is highly prevalent in the US with higher prevalence in the minority populations (9- 13.2%) as compared to non-Hispanic whites (7.6%). Efforts from large multi-ancestry consortia using genome- wide association studies (GWAS) approaches have successfully identified a large number of genetic variants associated with T2D. However, the majority of disease heritability remains unexplained and identification and characterization of the respective causal loci is limited. This is especially true for African Americans, the focus of this application, in which have led genetic exploration of type 2 diabetes genetics. Building on our establishment of the largest GWAS in African Americans in the Meta-analysis of Type 2 Diabetes in African Americans (MEDIA) Consortium and ongoing collaborations with other consortia on T2D and related traits, this project aims to use integrative phenomics analyses of genomics, metabolomics and transcriptomics in well- characterized samples to achieve the following specific aims. Aim 1: GWAS meta-analysis of baseline and dynamic glucose homeostasis traits and identification of functional variants and target genes using genomics and metabolomics. Aim 2: Integration of genomics, metabolomics and transcriptomics to identify functional variants and target genes for T2D. Aim 3: Integration of functional annotations, cross-trait associations and gene-gene/gene environment interactions to fine map T2D related loci and discover novel loci in African American and trans-ancestry GWAS.

非裔美国人2型糖尿病遗传学 项目摘要： 2型糖尿病（T2 D）在美国非常普遍，少数人群的患病率更高（9- 10岁）。 非西班牙裔白人（7.6%）。来自大型多祖先联盟的努力， 广泛关联研究（GWAS）方法已经成功地鉴定了大量的遗传变异 与T2 D有关。然而，大多数疾病的遗传性仍然无法解释， 各自的致病基因座的表征是有限的。这对非洲裔美国人来说尤其如此， 这一应用，其中导致了2型糖尿病遗传学的遗传探索。充分发挥两国 在非洲2型糖尿病的荟萃分析中建立非洲裔美国人中最大的GWAS 美国（媒体）联盟和正在进行的合作与其他财团对T2 D和相关性状，这 该项目旨在利用基因组学、代谢组学和转录组学的综合表型组学分析， 样品的特征，以实现以下具体目标。目标1：基线和基线的GWAS荟萃分析 动态葡萄糖稳态性状和使用基因组学鉴定功能变体和靶基因 和代谢组学。目的2：整合基因组学、代谢组学和转录组学， T2 D的变异和靶基因。目标3：整合功能注释、跨特质关联和 基因-基因/基因环境相互作用，以精细绘制非洲T2 D相关基因座并发现新基因座 美国和跨血统GWAS。