Engineered Nanomaterial Synthesis, Characterization and Method Development Center for Nano-safety Research

工程纳米材料合成、表征及纳米安全研究方法开发中心

• 批准号: 9308980
• 负责人: Philip Demokritou
• 金额: $ 75.86万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-15 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9308980
• 关键词: Advisory Committees; Animal Model; Applied Research; Assessment tool; Biodistribution; Biological; Carbon; Cell model; Chemicals; Collaborations; Communication; Communities; Coupled; Data; Development; Discipline; Engineering; Ensure; Equipment and supply inventories; Faculty; Florida; Generations; Goals; In Vitro; Industry; Interdisciplinary Study; Laboratories; Link; Maine; Medical Imaging; Metals; Methodology; Methods; Morphology; Nanotechnology; Preparation; Procedures; Property; Public Health Schools; Radio; Reporting; Research; Research Activity; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Risk; Safety; Schools; Science; Services; Standardization; Structure-Activity Relationship; Students; Surface; Suspensions; System; Techniques; Therapeutic; Time; Toxicology; Uncertainty; Universities; Work; analytical method; base; biological systems; chemical property; consumer product; cost effective; design; dosimetry; experience; faculty research; forest; graphene; improved; in vivo; innovation; instrument; instrumentation; interdisciplinary approach; interest; materials science; meetings; member; metal oxide; metallicity; method development; multidisciplinary; nano; nanobiology; nanocomposite; nanomaterials; nanoscale; nanotoxicology; novel; organizational structure; particle; repository; response; tool

PROJECT SUMMARY/ABSTRACT Given the increasingly vast and varied array of engineered nanomaterials (ENMs) being utilized in industry, incorporated into consumer products, and employed in medical imaging and therapeutic applications, understanding the relationships between their physicochemical properties and biointeractions is critical and will help in reducing the still great risk uncertainty surrounding ENMs. In response to this RFA, we propose to establish the “Engineered Nanomaterial Synthesis, Characterization and Method Development Coordination Center for Nano-safety Research”. Our proposed Center builds upon the infrastructure and interdisciplinary experience of existing academic research centers in the fields of ENM synthesis, characterization and nano-safety research. The infrastructure in these collaborating centers, developed over the past 15 years, includes an inter-disciplinary research group of faculty, researchers and students, as well as state-of-the-art platforms for high throughput synthesis of ENMs, including metal and metal oxides, cutting edge 2D/3D ENMs such as CNTs and graphene, nanocellulose, and advanced nanocomposites, coupled with innovative tools to assess the fate of ENMs in biological systems, statistical and exposure assessment tools, and novel in vitro/in-vivo platforms for nanotoxicology. The research outlined in this proposal extends beyond timely and cost-effective synthesis and characterization of reference ENMs and coordination services for the NHIR consortium community. We aim to work across disciplines, share new ideas, develop industry-relevant reference ENMs, and work with the consortium to develop multidisciplinary projects and standardized methods to advance our understanding of nano-EHS issues. The work will be accomplished through a number of highly interconnected cores/aims and research projects: 1) ENM synthesis Core: It will provide an extensive array of well-characterized, industry- relevant ENMs that cover both conventional and emerging advanced 2D/3D ENMs; 2)ENM Characterization Core: it will provide complete physicochemical characterization using state of the art instruments and analytical methods; 3) Reference ENM repository Core: Management of the reference ENM repository will include storage and distribution of ENMs to the consortium, assessment of property transformations and purity over time and development of optimized storage strategies and QA/QC procedures; 4) Method Development Core: It will develop standardized methods for dispersion preparation and characterization for toxicology studies, develop advanced dosimetry tools for fate and transport of ENMs in biological media, including corona characterization methods, and develop chemical and radio-tracing techniques to be used by nanotoxicology community to track biodistribution and translocation of ENMs in cellular and animal models; 5) Administration and Research Coordination Core: This core will provide oversight and coordination of all center investigators and core activities and coordinate research activities among consortium members.

项目摘要/摘要 鉴于工业中使用的工程纳米材料(ENM)的数量越来越多且种类越来越多， 整合到消费产品中，并用于医学成像和治疗应用， 了解它们的物理化学性质和生物相互作用之间的关系是至关重要的 将有助于减少围绕新能源管理的仍然巨大的风险不确定性。 针对这种RFA，我们建议建立“工程纳米材料合成， 纳米安全研究的特性和方法开发协调中心“。我们的 拟建中心建立在现有学术研究的基础设施和跨学科经验的基础上 主要从事ENM的合成、表征和纳米安全研究。其中的基础设施 合作中心在过去15年中发展起来，包括一个跨学科的研究小组， 教职员工、研究人员和学生，以及最先进的环氧乙烷高通量合成平台， 包括金属和金属氧化物、尖端2D/3D ENM，如碳纳米管和石墨烯、纳米纤维素和 先进的纳米复合材料，加上评估生物系统中ENM命运的创新工具， 统计和暴露评估工具，以及用于纳米毒理学的新的体外/体内平台。 本提案中概述的研究超越了及时和具有成本效益的综合和 Nhir联合体社区的参考ENM和协调服务的特征。我们的目标是 跨学科工作，分享新想法，开发与行业相关的参考ENM，并与 联合开发多学科项目和标准化方法，以促进我们对 纳米EHS问题。这项工作将通过若干高度互连的核心/目标和 研究项目：1)ENM合成核心：它将提供广泛的、具有良好特性的行业- 涵盖传统和新兴的高级2D/3D ENM的相关ENM；2)ENM特性 核心：它将使用最先进的仪器和分析工具提供完整的物理化学表征 方法；3)参考ENM库核心：参考ENM库的管理将包括 向财团储存和分发ENM，评估财产转换和纯度 优化存储策略和QA/QC程序的时间和开发；4)方法开发 核心：将开发毒理学分散体制备和表征的标准化方法 研究、开发先进的剂量学工具，用于ENM在生物介质中的去向和传输，包括电晕 表征方法，并开发供纳米毒理学使用的化学和放射性示踪技术 社区跟踪ENM在细胞和动物模型中的生物分布和移位；5)管理 和研究协调核心：该核心将为所有中心调查人员提供监督和协调 以及核心活动，并协调财团成员之间的研究活动。