Miniature EPR sensor for on-site oximetry

用于现场血氧测定的微型 EPR 传感器

• 批准号: 9281723
• 负责人: PERIANNAN KUPPUSAMY
• 金额: $ 17.52万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9281723
• 关键词: Address; Animal Model; Area; Arts; Blood; Blood flow; Caliber; Cardiovascular Diseases; Cardiovascular system; Clinic; Clinical; Complex; Coupling; Crystallization; Data; Detection; Development; Devices; Diagnosis; Disease; Electron Spin Resonance Spectroscopy; Electronics; Environment; Future; Goals; Home environment; Hyperbaric Oxygenation; Hypoxia; Image; Implant; In Vitro; Knowledge; Length; Magnetic Resonance; Magnetic Resonance Imaging; Malignant Neoplasms; Measurement; Measures; Methods; Molecular; Monitor; Needle biopsy procedure; Oxygen; Oxygen saturation measurement; Pathology; Patients; Performance; Permeability; Physiologic pulse; Polymers; Procedures; Pulse Oximetry; Risk; Safety; Sampling; Sensitivity and Specificity; Shapes; Side; Signal Transduction; Silicones; Site; Skin; Specificity; Surface; System; Techniques; Technology; Temperature; Thinness; Time; Tissues; Treatment outcome; Work; Wound Healing; base; biomaterial compatibility; blood oxygen level dependent; clinically relevant; clinically significant; design; diagnostic assay; implanted sensor; improved; in vivo; innovation; interest; magnetic field; miniaturize; novel; outcome forecast; portability; programs; sensor; targeted treatment; tissue oxygenation; tool; treatment site; usability; wound

Abstract Knowledge of tissue oxygen level has enormous clinical significance in the diagnosis, prognosis, and treatment of several pathologies including cardiovascular disease, cancer, and wound healing. However, there is an unmet need for devices that can measure tissue oxygen in patients with a reasonable degree of accuracy, reliability, and robustness. Although a number of methods are considered applicable for oxygen measurements in patients, they lack the ability to make repeated measurements to monitor temporal changes during or post-therapy. Electron paramagnetic resonance (EPR)-based oximetry offers certain unique advantages over other methods, including high accuracy, high sensitivity to pO2 and high functional specificity. Unfortunately, the use of EPR-based techniques for clinical purposes still needs to address a number of fundamental issues, most notably the restrictions that arise from existing hardware. Most conventional EPR systems are large, bulky units with restrictive spacing between the magnet poles. Importantly, patients must be brought to the EPR facility for oxygen measurements. Hence, considerable changes in EPR hardware are necessary to make this technology more appealing and available by bedside or at treatment site from a clinical standpoint. The overall goal of this exploratory project is to develop a highly innovative miniature EPR device capable of repeated monitoring of deep tissue pO2 in patients. We propose to construct a unique self- contained compact EPR sensor system, called implantable oxygen sensor that can be used on site in the clinic. In contrast to the existing EPR system, which requires a large external magnet, our approach will use an ultra-small permanent magnet, which will be integrated within a resonator holding the oxygen-sensing probe. The all-in-one implantable unit will be of 2-mm diameter and 6-mm length and will be driven by a novel compact spectrometer, based on state-of-the-art field programmable gate array (FPGA) electronics. The specific aims of the two-year project are: (i) To construct a miniature EPR sensor using permanent magnets, loop-gap resonator, and oxygen- sensing crystal embedded in a silicone polymer attached to a compact, simple and affordable pulse EPR spectrometer; (ii) To validate the EPR sensor performance in vitro and in vivo using animal model. This unique device will enable continuous on-site and real-time monitoring of deep- tissue pO2 and may become a vital tool for clinical use to optimize various therapies for improving treatment outcomes.

摘要

项目成果

Compact electron spin resonance skin oximeter: Properties and initial clinical results.

紧凑型电子自旋共振皮肤血氧计：特性和初步临床结果。

• DOI: 10.1002/mrm.28595
• 发表时间: 2021
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Cristea,David;Wolfson,Helen;Ahmad,Rizwan;Twig,Ygal;Kuppusamy,Periannan;Blank,Aharon
• 通讯作者: Blank,Aharon